E-therapeutics Share Discussion Threads

[ali47fish] 24/2/2016 10:22

down 21pc- any idea why?- this one has got Woodford invested and a string of well known managers!

[mach100] 15/2/2016 14:33

Not an investor here but have seen a few presentations at Mayfair. They looked interesting at that time. Today's RNS seems weird to me. It seemed to be presented as good news when it is probably anything but. A massive drop first thing and any bottom feeders would have done well. I can't see given the wooliness of the RNS any great upside on this so I confess I am slightly bemused by the share price partial recovery since the opening.

[proactivest] 15/2/2016 14:19

Video interview with CEO Young



E-Therapeutics (LON:ETX) chief executive Malcolm Young tells Proactive that the firm has hit the “sweet spot” on the drug candidate ETS6103 following its latest test results.

The Phase IIb study, which was a larger study at a lower dose showed the drug was a little bit off the efficacy of its rival amitriptyline, but was still effective.

But the firm has previously completed a Phase IIa study on ETS6103, which was carried out on a small number of patients at a higher dose, showing the drug had the same efficacy as its closest rival.

Young says that the drug has a “cleaner profile” than amitriptyline, and adds that “across the two studies, we are pleased.”

[longshanks] 15/2/2016 07:48

Yes. Disappointing results.ETS6103 confirmed as effective in treating second line depressive conditions but not as effective as tricyclics (which is what was hoped).Tricyclics have more side effects and so they hold onto this as giving ETS6103 some value; but overall the results are disappointing IMO.

[dynoport] 15/2/2016 07:30

Eh? can anyone decipher this?

[aim_trader] 22/9/2015 09:24

Malcolm Young, CEO of e-Therapeutics, will be presenting to investors at the Chesterfield Hotel in Mayfair on the 24th September from 6pm. To register to attend, please click here:

[dynoport] 31/3/2015 07:22

looking very positive :-)

[curriedquaker] 09/3/2015 20:43

Woodford and Henderson buying, the institutions are topping up, they must think there are good times ahead. Have been a long time holder and looking forward to the next couple of years. onward and upward

[timbo003] 27/2/2015 21:09

Tolmers, re your question on post #111

I sold out in the low thirties a few weeks ago (Lorraine still holds).

The current market cap of £100m seems a bit on the high side based on the likely risk adjusted value for the two drugs currently in the clinic, but having said that, I find it very difficult to value the other part of the business, i.e. their proprietary Network Pharmacology technology which could be worth hundreds of millions of dollars to a large pharma looking to get a fast track into the technology. I'm not sure exactly how validated the network technology is, they are claiming that their hit rate is orders of magnitude greater than conventional screening methods, but I think it really does need to be validated by one or more clinical successes before assigning a potential value.

[hutch_pod] 26/2/2015 22:06

I must admit I'm now a bit confused whether the RNS was reiterating previous, or emphasising the continuation of promising results.

[curriedquaker] 26/2/2015 17:41

At least the RNS didn't say that the company had no idea why there is a recent rise in its share price. All it did was reiterate what has already been communicated. Hopefully the press will make a comment tomorrow morning and we'll see if this continues upwards or the profit taking will take hold

[127tolmers] 26/2/2015 15:13

26 February 2015, Oxford and Newcastle, UK: e-Therapeutics plc (AIM: ETX), the drug discovery and development company, notes the recent rise in its share price and confirms the following.

The Company has continued to observe high levels of productivity through the application of its proprietary drug discovery processes, finding a large number of highly active molecules in cellular screens for molecules selected by the discovery platform, as was noted in the RNS issued on 27 November 2014.

e-Therapeutics believes that this yield of active compounds represents a proportion of those screened that is several orders of magnitude higher than the published ranges observed in conventional drug discovery processes. The Company believes this enrichment reflects the utility of using its proprietary approach to network science and chemical biology to enhance the selection of molecules that are likely to be attractive for further development. The Company continues to focus its discovery team on generating a substantial number of strong candidate molecules across several disease areas.

Discovery and development activity at the Company otherwise continues in line with stated plans and the Company intends to provide a further update in its full year results for the year ended January 2015, expected to be released on 31 March 2015.

[127tolmers] 26/2/2015 15:12

Timbo re your 83, still a hold until 31 March?

[bodroll] 26/2/2015 13:46

Yes, HP. Somebody knows something, but what is it I wonder?
Great to see such a large rise in the SP, and I am eagerly awaiting RNS so we all can discover the reason.
However, if there is no news, an early RNS to say so is required

[curriedquaker] 26/2/2015 12:51

Thanks, Hutch_Pod, interesting article, maybe the yanks are looking for the next billion dollar company. Maybe we should send them a link to ETX.

[hutch_pod] 26/2/2015 08:58

Biotech is looking strong over in the US, and perhaps this helped?

[curriedquaker] 25/2/2015 20:00

Anybody out there know what is causing this price rise with virtually no trading volume? Tomorrow also looks like a blue day.. somebody knows something.

[curriedquaker] 30/1/2015 15:51

This is starting to slowly gain some momentum. Have been a long term holder and hopefully 2015 will see the fruits of my patience. Directors having a nibble so onward and upward. dyor.

[dynoport] 21/1/2015 16:44

9.8million traded today! price hardly moves. Director bought 150000 what about the rest?

[127tolmers] 04/12/2014 12:17

Did anyone go to the investor presentation 27 Nov?

Big trade today. Woodford?

[127tolmers] 09/7/2014 16:54

Did anyone go to the AGM today?

[timbo003] 12/5/2014 13:10

Today's results didn't tell us much new, but nether the less, quite a reassuring update.

Bit of press coverage here:



I also note they are attending this partnering event this week:

[127tolmers] 07/5/2014 19:57

Presumably the 10% stake picked up by Woodford Investment management on 2 May should be taken as a vote of confidence.

[127tolmers] 27/4/2014 20:08

The company had a stand at the Master Investor event at Islington this weekend but were not presenting. I was caught by surprise that they were there. I spoke to Malcolm Young and another of his staff. They seem quite positive about the restart of their tests and were emphatic that they had sufficient near term funds.