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| Share Name | Share Symbol | Market | Type | Share ISIN | Share Description |
|---|---|---|---|---|---|
| Destiny Pharma Plc | LSE:DEST | London | Ordinary Share | GB00BDHSP575 | ORD GBP0.01 |
| Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
|---|---|---|---|---|---|---|---|---|---|---|
| -0.50 | -2.27% | 21.50 | 21.00 | 22.00 | 21.75 | 21.50 | 21.75 | 184,683 | 16:25:45 |
| Industry Sector | Turnover | Profit | EPS - Basic | PE Ratio | Market Cap |
|---|---|---|---|---|---|
| Pharmaceutical Preparations | 0 | -6.5M | -0.0683 | -3.15 | 20.48M |
From Apr 2019 to Apr 2024
TIDMDEST
RNS Number : 2268Z
Destiny Pharma PLC
17 September 2020
Destiny Pharma plc
("Destiny Pharma" or the "Company")
Interim results for the six months ended 30 June 2020
Lead product to prevent post-surgical infections in Phase 2b clinical trial
Recruitment planned to complete by end of 2020; results expected in Q1 2021
Grant funded COVID-19 collaboration announced
Company funded to Q4 2021
Brighton, United Kingdom - 17 September 2020 - Destiny Pharma (AIM: DEST), a clinical stage biotechnology company focused on the development of novel products to prevent life threatening infections, announces its unaudited interim financial results for the half-year ended 30 June 2020 and an update for the year to date.
Operational highlights
Phase 2b clinical trial: XF-73 nasal gel for prevention of post-surgical infections
-- Protocol amendment agreed with FDA and Phase 2b XF-73 nasal study size revised to 125 patients with recruitment planned to complete by end of 2020
-- Quality of study and statistical quality of Phase 2b not affected by reduction in size
-- Positive interim safety analysis of Phase 2b trial performed by independent data monitoring committee
-- Good recruitment momentum post COVID-19 delays. Refer to separate Clinical Update announced today
Financial highlights
-- Strong cash position with cash and term deposits at 30 June 2020 of GBP5.6 million (30 June 2019: GBP9.1 million; 31 December 2019: GBP7.5 million)
-- Expenditure on R&D in the period of GBP2.3 million (half-year 2019: GBP1.7 million; full year 2019: GBP3.8 million) reflecting the increased investment in clinical research
-- Company funded through to Q4 2021
SporeGen COVID-19 collaboration
-- Destiny Pharma and SporeGen announced collaboration and Innovate UK grant award of GBP800,000 to co-develop a novel, preventative product for COVID-19
-- Expands Destiny Pharma's novel pipeline targeted at preventing infections with novel biologics/microbiome approach
Earlier pipeline and research projects
-- Research projects with Cardiff, Sheffield, Southampton and Aston Universities making progress after COVID-19 delays
-- New grant awarded by National Biofilms Innovation Centre (NBIC) to fund a second research collaboration with Cardiff University in oral infections
-- Oxford University review supports the unique target profile of XF-73 and its potential to address the threat of anti-microbial resistance (AMR)
Neil Clark, CEO of Destiny Pharma, commented:
"Destiny Pharma has made great progress in 2020. We agreed a protocol amendment with the US FDA and announced a good interim safety review on our important Phase 2b study of our lead drug candidate, XF-73, for the prevention of post-surgical hospital infections. We now look forward to completing patient recruitment by the end of 2020 and announcing results in Q1 2021. This is the major value driver for the company.
We remain very positive on the clinical need and commercial opportunity for XF-73 in the hospital setting which we estimate in the US alone to be peak annual product sales of $1 billion.
Our pipeline of unique infection prevention products has recently been expanded with SPOR-COV, a novel, preventative treatment for COVID-19. This product is being co-developed with SporeGen Ltd and supported by an GBP800,000 Innovate UK grant.
COVID-19 has highlighted vividly the healthcare impact of infectious disease and we are convinced that Destiny Pharma's unique pipeline has the potential to deliver novel commercially attractive products to prevent life threatening infections."
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
+44 (0)1273 704 440
pressoffice@destinypharma.com
Optimum Strategic Communications
Mary Clark, Shabnam Bashir, Manel Mateus
+44 (0)20 3174 1789
DestinyPharma@optimumcomms.com
finnCap Ltd (Nominated Adviser and Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0)20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0)20 3705 9321
About Destiny Pharma
Destiny Pharma is an established, clinical stage, innovative biotechnology company focused on the development and commercialisation of novel medicines that can prevent life threatening infections. The company's lead programme is undergoing a Phase 2b clinical trial and is targeting the prevention of post-surgical hospital infections including MRSA. The XF drug candidates are being developed for the prevention and treatment of life-threatening infections caused by antibiotic--resistant bacteria, often referred to as "superbugs". Tackling anti-microbial resistance has become a global imperative recognised by the World Health Organization (WHO) and the United Nations, as well as the G7 and the G20 countries. Destiny Pharma is also collaborating with SporeGen(R) to co-develop a novel, preventative product for COVID-19. For further information, please visit https://www.destinypharma.com
Forward looking statements
Certain information contained in this announcement, including any information as to the Group's strategy, plans or future financial or operating performance, constitutes "forward-looking statements". These forward looking statements may be identified by the use of forward-looking terminology, including the terms "believes", "estimates", "anticipates", "projects", "expects", "intends", "aims", "plans", "predicts", "may", "will", "seeks" "could" "targets" "assumes" "positioned" or "should" or, in each case, their negative or other variations or comparable terminology, or by discussions of strategy, plans, objectives, goals, future events or intentions. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this announcement and include statements regarding the intentions, beliefs or current expectations of the Directors concerning, among other things, the Group's results of operations, financial condition, prospects, growth, strategies and the industries in which the Group operates. The directors of the company believe that the expectations reflected in these statements are reasonable, but may be affected by a number of variables which could cause actual results or trends to differ materially. Each forward-looking statement speaks only as of the date of the particular statement. By their nature, forward-looking statements involve risks and uncertainties because they relate to events and depend on circumstances that may or may not occur in the future or are beyond the Group's control. Forward looking statements are not guarantees of future performance. Even if the Group's actual results of operations, financial condition and the development of the industries in which the Group operates are consistent with the forward-looking statements contained in this document, those results or developments may not be indicative of results or developments in subsequent periods.
Chief Executive Officer's Statement
Operational review summary
The Company's lead asset, XF-73, has been developed from Destiny Pharma's novel, antimicrobial "XF" drug platform. Unlike most antibiotics, XF drugs have not been seen to generate bacterial resistance in industry-standard microbiology tests and therefore have significant potential to address the global threat of anti-microbial resistance (AMR).
XF-73 has been shown to kill bacteria very rapidly and is planned to be an effective new treatment in the reduction of bacterial infections in hospital patients after surgery, including those caused by methicillin resistant Staphylococcus aureus (MRSA). XF-73 is administered topically as a nasal gel whereby it reduces the nasal carriage of the bacteria Staphylococcus aureus, which is the source of many post-surgical bacterial infections. There is currently no approved product in the US for the reduction of post-surgical staphylococcal infections although approximately a third of all patients have nasal Staphylococcal aureus carriage as they enter surgery.
This strong clinical need is supported by feedback from market research targeting physicians, pharmacists and payers in the US who are responsible for managing hospital infections and the associated cost implications. This research also supports the commercial plans for XF-73 nasal gel as a new hospital product in a poorly served multi-billion dollar market.
The addition of SPOR-COV, a COVID-19 preventative treatment, to our pipeline through a new collaboration with SporeGen Limited is confirmation of our strategy to enlarge our pipeline and is an exciting move into the biologicals/microbiome sector. The potential of this asset was validated by the concurrent award of an
GBP800,000 Innovate UK grant.
Phase 2b clinical trial
The Phase 2b clinical study is recruiting patients undergoing open heart surgery in United States and Europe and has now recruited 88 patients out of the target of 125. Barring any further impact from COVID-19 the study is on plan to complete recruitment by the end of 2020 and report results in Q1 2021.
In July, Destiny Pharma agreed a protocol amendment with the FDA that reduced the size of the study and also reported excellent interim safety data. Importantly the reduced size of the study does not compromise its integrity, statistical relevance or clinical objectives.
The agreed protocol amendment recognised the impact COVID-19 has had in slowing patient recruitment in clinical studies since March and the FDA's willingness to support certain protocol amendments that help to accelerate the completion of ongoing clinical trials but do not compromise a study's integrity and clinical objectives. The amendment to the protocol incorporated a change to the primary patient population where the primary endpoint for the study will be measured. The primary microbiological endpoint post-surgery is now being measured in patients who have a positive load of nasal Staphylococcus aureus before receiving the study treatment. This contrasts to the original primary population, which included all randomised patients regardless of their baseline nasal load of Staphylococcus aureus. Very importantly, this change enabled a reduction in the defined study size from 200 patients to 125 while maintaining the statistical power of the study and its clinical value. This preserved the potential of the trial results to be a key step towards the Phase 3 clinical trial programme of XF-73. Other protocol modifications agreed with the FDA regarding study procedures will also make it easier for hospitals to recruit and retain hospital patients
An interim safety review was completed by an Independent Data Monitoring Committee (IDMC) of the Phase 2b study. The committee reviewed safety data from the first 75 patients who completed study treatment. Adverse event data, including safety laboratory results, incidence of post-operative infections, ear, nose, and throat examinations, as well as sense of smell tests were reviewed by the IDMC. Based on their evaluation, the IDMC recommended that the study could continue without any modifications to the protocol.
SPOR-COV - a new COVID-19 project
Earlier this month Destiny Pharma entered into a collaboration agreement with SporeGen Limited to co-develop SporeGen's SPOR-COV product as a novel, preventative treatment for COVID-19.
Under the agreement, the parties will share any costs and commercial returns from SPOR-COV and plan to complete a pre-clinical programme with the aim of being ready to enter the first human clinical trials within 18 months.
The SPOR--COV product consists of a proprietary formulation of Bacillus bacteria that will be administered nasally as a spray. SPOR-COV has already been shown by SporeGen to provide complete (100%) protection in preclinical models of influenza virus.
SPOR-COV is different to vaccines in that it utilises the innate immune system with the aim of developing COVID-19 protection a few days after dosing. As an "easy to use" first line of defence, it has the potential to reduce COVID-19 infection rates and transmission significantly. The final SPOR-COV product is planned to be straightforward to produce at high volumes and at low cost. It can also be stockpiled almost indefinitely without the need for cold chain refrigeration. It could be made available globally as a cost-effective measure in the fight against COVID-19 as well as new COVID strains and other respiratory viral infections.
The SPOR-COV programme is supported by an Innovation UK grant of GBP800,000 which will fund the majority of the GBP1 million cost of the initial SPOR-COV programme.
XF Research update
The Company's earlier pipeline is largely funded through non-dilutive grant funding. These projects are looking at the utility of XF compounds in preventing and/or treatment of infections in ocular, respiratory, dermal and oral indications. Progress on these projects has been slowed due to COVID-19 and the associated restrictions on University based laboratory work but activity is planned to increase in the last quarter of 2020.
.
The pipeline was expanded further in in the first half of 2020 as Destiny Pharma was jointly awarded a National Biofilms Innovation Centre (NBIC) grant to fund a research collaboration with Cardiff University. The project will establish the potential of three of the Company's proprietary XF drug compounds, DPD--207, XF-70 and XF-73 as novel treatments for clinically important fungal infections in mucosal mouth models of disease.
The promising no/low resistance profile of XF-73 was supported by the publication of a new independent paper in Trends in Microbiology, entitled: "Assessing the potential for Staphylococcus aureus to evolve resistance to XF-73".
The review looked at data from a number of established microbiology models that were used to evaluate the action of XF-73 in killing S. aureus that were carried out previously by Destiny Pharma. The paper concluded that the available evidence suggests that S. aureus has low potential to evolve resistance to XF-73 relative to antibiotics. This conclusion supports the Company's own view that XF-73 has a unique resistance profile due to its novel, ultra-fast mechanism of action that is a key advantage compared to typical antibiotics.
Outlook
Destiny Pharma is well funded to complete the Phase 2 clinical development of its lead drug asset, XF-73. The Company is currently designing the Phase 3 clinical study that will hopefully follow. Importantly, market analysis supports the clinical need and commercial opportunity for XF-73 in the prevention of post-surgery hospital infections, such as those caused by MRSA, which is estimated to be over a $1 billion market opportunity in the US alone.
Six grant awards worth over GBP2.5 million have been awarded to Destiny Pharma projects since 2018 and are being used to help develop new clinical candidates from the Company's XF pipeline and the SPOR-COV project. This demonstrates the potential value in Destiny's growing pipeline. The Company is well funded to execute on its business strategy and to progress its lead and follow-on programmes through the planned clinical studies in 2020 with a cash runway that extends to Q4 2021.
There is increased international support for the development of novel anti-infective drugs that address the issue of anti-microbial resistance and Destiny Pharma's unique platform is very well-positioned to meet this global need. The significant healthcare and economic impact of COVID-19 has highlighted clearly the global need for innovation that delivers fast, safe and affordable anti-infection treatments.
Neil Clark
Chief Executive Officer
17 September 2020
Condensed Statement of Comprehensive Income
For the 6 months ended 30 June 2020
Hot Features
Premium
6 months ended 6 months ended Year ended
30 June 2020 30 June 2019 31 December
Unaudited Unaudited 2019
GBP GBP Audited
GBP
Continuing operations
Revenue - - -
Administrative expenses (2,912,801) (2,556,773) (5,687,003)
Other operating income 12,450 198,474 305,906
Share option charge (58,668) (109,454) (203,655)
----------------------------- --------------- --------------- -------------
Operating loss (2,959,019) (2,467,753) (5,584,752)
Finance income 13,470 40,316 63,478
----------------------------- --------------- --------------- -------------
Loss before tax (2,945,549) (2,427,437) (5,521,274)
Income Tax 515,378 332,413 813,250
----------------------------- --------------- --------------- -------------
Loss for the period (2,430,171) (2,095,024) (4,708,024)
Other comprehensive income - - -
----------------------------- --------------- --------------- -------------
Total comprehensive loss
from continuing operations (2,430,171) (2,095,024) (4,708,024)
----------------------------- --------------- --------------- -------------
Loss per share (Note 5)
Basic and diluted (5.5)p (4.8)p (10.7)p
----------------------------- --------------- --------------- -------------
Condensed Statement of Financial Position
For the 6 months ended 30 June 2020
As at As at As at
30 June 2020 30 June 2019 31 December
Unaudited Unaudited 2019
GBP GBP Audited
GBP
ASSETS
Non-current assets
Property, plant and equipment
(Note 6) 25,764 38,031 32,922
Current assets
Trade and other receivables 559,747 1,259,349 911,198
Prepayments and accrued income 48,192 186,157 133,702
Cash and cash equivalents 5,571,631 5,077,954 7,479,642
Other financial assets - 4,000,000 -
Current assets 6,179,570 10,523,460 8,524,542
-------------------------------- -------------- -------------- -------------
TOTAL ASSETS 6,205,334 10,561,491 8,557,464
-------------------------------- -------------- -------------- -------------
EQUITY AND LIABILITIES
Current liabilities
Trade and other payables 817,512 283,367 798,139
-------------------------------- -------------- -------------- -------------
Current liabilities 817,512 283,367 798,139
-------------------------------- -------------- -------------- -------------
Shareholders' equity
Issued share capital (Note
7) 438,652 438,652 438,652 Share premium 17,296,337 17,296,337 17,296,337 Accumulated losses (12,347,167) (7,456,865) (9,975,664) -------------------------------- -------------- -------------- ------------- Total shareholders' equity 5,387,822 10,278,124 7,759,325 -------------------------------- -------------- -------------- ------------- TOTAL EQUITY AND LIABILITIES 6,205,334 10,561,491 8,557,464 -------------------------------- -------------- -------------- -------------
Condensed Statement of Changes in Equity
For the 6 months ended 30 June 2020
Issued share Share Accumulated
capital premium losses Total
GBP GBP GBP GBP
As at 1 January 2020 438,652 17,296,337 (9,975,664) 7,759,325
Loss and total comprehensive
loss
for the period - - (2,430,171) (2,430,171)
Share based payment
expense - - 58,668 58,668
As at 30 June 2020 438,652 17,296,337 (12,347,167) 5,387,822
------------------------------ ------------- ----------- -------------- --------------
Issued share Share Accumulated
capital premium losses Total
GBP GBP GBP GBP
As at 1 January 2019 435,626 17,292,284 (5,471,295) 12,256,615
Total comprehensive
loss and loss
for the period - - (2,095,024) (2,095,024)
Issue of share capital 3,026 4,053 7,079
Share based payment
expense - - 109,454 109,454
As at 30 June 2019 438,652 17,296,337 (7,456,865) 10,278,124
------------------------- ------------- ----------- ------------- -------------
Issued share Share Accumulated
capital premium losses Total
GBP GBP GBP GBP
As at 1 January 2019 435,626 17,292,284 (5,471,295) 12,256,615
Loss and total comprehensive
loss for the period
Issue of share capital (4,708,024) (4,708,024)
Share based payment
expense 3,026 4,053 - 7,079
- - 203,655 203,655
As at 31 December 2019 438,652 17,296,337 (9,975,664) 7,759,325
------------------------------ ------------- ----------- ------------- -------------
Condensed Statement of Cash Flows
For the 6 months ended 30 June 2020
6 months ended 6 months ended Year ended
30 June 2020 30 June 2019 31 December
Unaudited Unaudited 2019
GBP GBP Audited
GBP
Cash flows from operating activities
Loss before income tax (2,945,549) (2,427,437) (5,521,274)
Depreciation charges (note
6) 9,017 8,868 18,440
Share based payment expense 58,668 109,454 203,655
Finance income (13,470) (40,316) (63,478)
Decrease/(increase) in trade
and other receivables and prepayments 113,260 (145,928) (79,800)
Increase/(decrease) in trade
and other payables 19,373 518,425 (3,653)
Tax received 839,079 - 815,316
---------------------------------------- --------------- ----------------------- -------------
Net cash used in operating
activities (1,919,622) (3,013,784) (4,630,794)
---------------------------------------- --------------- ----------------------- -------------
Cash flows from investing activities
Purchase of tangible fixed
assets (1,859) (16,478) (20,942)
Maturity of other financial
assets - 5,000,000 5,000,000
Purchase of other financial - (4,000,000) -
assets
Interest received 13,470 40,316 63,478
Net cash flow from investing
activities 11,611 1,023,838 5,042,536
---------------------------------------- --------------- ----------------------- -------------
Cash flows from financing activities
New shares issued net of issue
costs - 7,079 7,079
---------------------------------------- --------------- ----------------------- -------------
Net cash inflow from financing
activities - 7,079 7,079
---------------------------------------- --------------- ----------------------- -------------
Net decrease in cash and cash
equivalents (1,908,011) (1,982,867) 418,821
Cash and cash equivalents at
the beginning of the period 7,479,642 7,060,821 7,060,821
---------------------------------------- --------------- ----------------------- -------------
Cash and cash equivalents at
the end of the period 5,571,631 5,077,954 7,479,642
---------------------------------------- --------------- ----------------------- -------------
Notes to the Condensed Financial Statements
1. General Information
Destiny Pharma plc ("Destiny", or the "Company") was incorporated and domiciled in the UK on 4 March 1996 with registration number 03167025. Destiny's registered office is located at Unit 36 Sussex Innovation Centre Science Park Square, Falmer, Brighton, BN1 9SB.
Destiny is engaged in the discovery, development and commercialisation of new antimicrobials that have unique properties to improve outcomes for patients and the delivery of medical care into the future.
2. Basis of Preparation
These interim unaudited financial statements have been prepared in accordance with AIM Rule 18, ' Half yearly reports and accounts' . The financial information contained in these interim financial statements have been prepared under the historical cost convention and on a going concern basis. The interim financial information for the six months ended 30 June 2020 and for the six months ended 30 June 2019 contained within this interim report do not comprise statutory accounts within the meaning of section 434 of the Companies Act 2006.
In the opinion of the Directors, the interim consolidated financial information presents fairly the financial position, and results from operations and cash flows for the period. Comparative amounts for the six months ended 30 June 2019 are also unaudited.
The interim financial statements for the six months ended 30 June 2020 were approved by the Board on 16 September 2020.
3. Accounting Policies
The unaudited interim financial statements for the period have been prepared on the basis of the accounting policies adopted in the audited report and accounts of the Company for the year ended 31 December 2019 and expected to be adopted in the financial year ending 31 December 2020.
IFRS16 'Leases' became applicable to the Company on 1 January 2019. The Company has elected not to apply the requirements of paragraphs 22 to 49 of IFRS16 in relation to short term leases and has no material leases which are other than short term. The adoption of IFRS16 therefore had no impact on the unaudited interim financial statements and no adjustments were required as a consequence of its adoption.
4. Segmental Information
The chief operating decision-maker is considered to be the Board of Directors of Destiny. The chief operating decision-maker allocates resources and assesses performance of the business and other activities at the operating segment level.
The chief operating decision maker has determined that Destiny has one operating segment, the development and commercialisation of pharmaceutical formulations.
Geographical Segments
The Company's only geographical segment during the period was the UK.
5. Loss Per Share
The calculation for loss per ordinary share (basic and diluted) for the relevant period is based on the earnings after income tax attributable to equity shareholders for the period. As the company made losses during the period, there are no dilutive potential ordinary shares in issue, and therefore basic and diluted loss per share are identical. The calculation is as follows:
6 months ended 6 months ended Year ended
30 June 2020 30 June 2019 31 December
Unaudited Unaudited 2019
GBP GBP Audited
GBP
Loss for the period from
continuing operations (2,430,171) (2,095,024) (4,708,024)
-------------------------- --------------- --------------- -------------
Weighted average number
of shares 43,865,195 43,733,614 43,799,945
Loss per share - pence
-------------------------- --------------- --------------- -------------
Basic and diluted (5.5)p (4.8)p (10.7)p
-------------------------- --------------- --------------- -------------
6. Property, plant and equipment
Plant and
machinery
GBP
Cost
At 1 January 2020 118,089
Additions 1,859
At 30 June 2020 119,948
-------------------------------- -----------
Depreciation
At 1 January 2020 85,167
Charge for the period 9017
At 30 June 2020 94,184
-------------------------------- -----------
Net book value at 30 June 2020 25,764
-------------------------------- -----------
Plant and
machinery
GBP
Cost
At 1 January 2019 97,147
Additions 16,478
At 30 June 2019 113,625
-------------------------------- -----------
Depreciation
At 1 January 2019 66,726
Charge for the period 8,868
At 30 June 2019 75,594
-------------------------------- -----------
Net book value at 30 June 2019 38,031
-------------------------------- -----------
Property, plant and equipment (contd.)
Plant and
machinery
GBP
Cost
At 1 January 2019 97,147
Additions 20,942
At 31 December 2019 118,089
------------------------------------ -----------
Depreciation
At 1 January 2019 66,726
Charge for the year 18,440
At 31 December 2019 85,167
------------------------------------ -----------
Net book value at 31 December 2019 32,922
------------------------------------ -----------
7. Share capital
On 18 June 2019, 150,000 Employee LTIP options in respect of Shaun Claydon were cancelled.
On 19 June 2019, 125,000 Employee LTIP Options were granted to Shaun Claydon and 40,000 Employee LTIP Options were granted to Jesus Gonzalez. These options have been granted at a price of GBP0.01 per ordinary share and for Shaun Claydon the Options will vest on 26 October 2021. The options granted to Jesus Gonzales will vest on the third anniversary of the date of grant. Both Option grants are exercisable for ten years after the date of grant.
8. Events after the end of the reporting period
There are no events subsequent to the reporting period that require adjustment or disclosure.
9. Copies of the interim financial statements
Copies of these interim unaudited financial statements are available on the Company's website at www.destinypharma.com and from the Company's registered office, Unit 36 Sussex Innovation Centre Science Park Square, Falmer, Brighton, BN1 9SB.
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