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ARIX Arix Bioscience Plc

142.00
0.00 (0.00%)
19 Apr 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Arix Bioscience Plc LSE:ARIX London Ordinary Share GB00BD045071 ORD 0.001P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 142.00 0.00 01:00:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
0 0 N/A 0

Arix Bioscience plc Annual Results for the year ended 31 December 2019

10/03/2020 7:00am

UK Regulatory


 
TIDMARIX 
 
Arix Bioscience plc 
 
             Full year results for the year ended 31 December 2019 
 
LONDON, 10 March 2020: Arix Bioscience plc ("Arix", LSE: ARIX) a global venture 
capital company focused on investing in and building breakthrough biotech 
companies, today announces its full year results for the year ended 31 December 
2019. 
 
Financial performance 
 
  * Net Asset Value (NAV) of GBP202 million (December 2018: GBP270 million), 149 
    pence per share (December 2018: 200 pence per share). Equates to a 25% 
    decline in NAV per share for the year versus a 32% increase in 2018 
  * Gross Portfolio valued at GBP149 million (December 2018: GBP175 million), and GBP 
    5m of cash realisations in the period 
      + Uplifts including Aura (Series D), Harpoon (Nasdaq IPO), Quench Bio 
        (Series A) outweighed by volatility of public holdings, notably a 60% 
        decline in Autolus' share price 
  * GBP36 million of capital deployed into the Gross Portfolio during the period 
  * Cash of GBP55 million at 31 December 2019 (December 2018: GBP91 million) 
 
Two new portfolio companies added to the portfolio: 
 
  * Co-led a $63.0 million Series B financing in new portfolio company Imara, 
    committing $15.0 million (GBP11.4 million) for a 9.9% stake 
  * Co-led a EUR20.0 million Series A in new portfolio company STipe 
    Therapeutics, committing EUR5.7 million (GBP4.9 million) for a 19.8% stake. 
    Christian Schetter, Arix Entrepreneur in Residence, appointed as STipe's 
    Executive Chairman 
 
Funding continued growth in the portfolio 
 
  * Harpoon (T cell engagers) raised net proceeds of $70.7 million in a Nasdaq 
    IPO, in which Arix invested $6.0 million (GBP4.7 million) 
  * Autolus (CAR-T cell immunotherapy) completed a $108.8 million follow-on 
    financing in which Arix invested a further $5.0 million (GBP3.8 million) 
  * Aura Biosciences (ocular melanoma) completed a $40.0 million Series D 
    financing, in which Arix committed a further $4.5 million (GBP3.4 million) 
 
Together with the two new portfolio companies, these companies raised $322 
million in aggregate over the period. 
 
Continued clinical progress in the portfolio, with 26 live clinical trials 
 
Over the period a number of companies reached important clinical milestones, 
notably: 
 
  * Aura presented further positive safety and efficacy data from the ongoing 
    AU-011 Phase 1b/2 study for choroidal melanoma 
  * Autolus reported encouraging data from its AUTO1 programme in adult acute 
    lymphoblastic leukaemia (aALL), as well as early results from its AUTO3 
    programme in diffuse large B-cell lymphoma (DLBCL) 
  * Amplyx announced positive interim Phase 2 data from its lead programme 
    APX001 in candidemia 
  * Harpoon  initiated a Phase 1/2a clinical trial for HPN536, a 
    mesothelin-targeting T cell engager, for the treatment of ovarian cancer 
    and other mesothelin-expressing solid tumours 
  * Imara reported interim Phase 2a data from its IMR-687 clinical study for 
    patients with sickle cell disease, showing proof of concept clinical 
    activity 
  * VelosBio transitioned to a clinical stage company, initiating the VLS-101 
    Phase 1 clinical study for the treatment of haematological cancers 
 
Post period end 
 
Quench Bio launched from stealth with Series A financing 
 
In January, Arix announced the Series A financing and launch of Quench Bio, a 
company that Arix created and seeded with Atlas Venture in June 2018. The 
Series A financing recognised a 40% uplift to the seed financing. Following the 
financing Arix retains a 21.7% stake in the business. This is the first company 
co-founded and formed by Arix from scratch, combining scientific discoveries 
from professors in Germany with entrepreneurs and co-investors in Boston. It 
encapsulates the benefits of Arix's transatlantic footprint and culture. 
 
Autolus raised $72.4 million in a public offering and reported additional 
encouraging data in AUTO3 
 
In January, Autolus completed a follow-on financing raising net proceeds of 
approximately $72.4 million. Following the offering Arix retains a 6.5% 
ownership stake. This financing will enable Autolus to develop its lead 
programme, AUTO1, in adult ALL through its Phase 2 trial and advance its next 
generation of T cell therapies into the clinic. 
 
Appointment of Dr. Roberto Iacone as Entrepreneur in Residence 
 
Dr. Roberto Iacone has been appointed as the second Entrepreneur in Residence 
at Arix. Roberto will focus on company creation, sourcing early stage European 
opportunities with Arix partner, Takeda Ventures, Inc., the strategic venture 
investing arm of Takeda Pharmaceuticals. This new role extends Arix's 
collaboration with Takeda Ventures to identify opportunities for early stage 
investment and create new biotechnology companies together. 
 
Iterum raised $52 million through a private placement 
 
Following the disappointing news, announced in Q4 2019, that results from its 
Phase 3 trial in complicated intra-abdominal infections narrowly missed its 
primary endpoint, Iterum completed a $51.9 million private placement with new 
and existing investors in January 2020. This will enable the company to fund 
the continued Phase 3 clinical development of sulopenem and the management of 
regulatory filings. Arix agreed to invest $1.9 million (GBP1.5 million) in the 
financing. This investment is in addition to Arix's existing stake of 7.3% in 
Iterum (amounting to 1,089,903 ordinary shares). 
 
Key anticipated milestones 
 
The company notes key clinical milestones anticipated by its portfolio 
companies in 2020: 
 
  * Artios expects to initiate a Phase 1 study in ATM-deficient tumours by the 
    end 2020 
  * Atox Bio expects to announce results from the ACCUTE Phase 3 clinical study 
    in necrotising soft tissue infections in H1 2020 
  * Aura expects to initiate the AU-011 Phase 3 clinical study for choroidal 
    melanoma in the H2 2020 
  * Amplyx expects to announce further Phase 2 data for APX001 in candidemia in 
    2020 
  * Autolus expects to initiate a Phase 2 registration trial of AUTO1 in adult 
    ALL in H1 2020 and present updated Phase 1 data in H1 and H2 2020 
  * Autolus expects to make a go/no go decision on Phase 2 initiation of AUTO3 
    in DLBCL in mid-2020 
  * Autolus expects to announce interim Phase 1 AUTO4 T cell lymphoma data in 
    H2 2020 
  * Autolus expects next generation (NG) programmes to enter the clinic in 2020 
  * Harpoon expects to present interim data from its HPN424 Phase 1 clinical 
    study in prostate cancer in H1 2020 
  * Harpoon expects to present data from its HPN536 Phase1/2a clinical trial 
    for ovarian cancer and other mesothelin-expressing solid tumours in H2 2020 
  * Harpoon expects to initiate the HPN217 Phase 1 trial for the treatment of 
    multiple myeloma and the HPN328 Phase 1 clinical study in small cell lung 
    cancer in 2020 
  * Imara expects to announce updated results from its IMR-687 Phase 2a 
    clinical study in sickle cell disease (SCD) by the end of 2020 
  * Imara expects to initiate Phase 2b trials for SCD and beta thalassemia in 
    H1 2020 
  * Iterum expects to announce results from the SURE 1 Phase 3 clinical study 
    in uncomplicated urinary tract Infections and the SURE 2 Phase 3 clinical 
    study in complicated urinary tract infections in H1 2020 
  * Pharmaxis expects to announce Phase 1b results from its systemic LOX 
    inhibitor for myelofibrosis and/or pancreatic cancer in H1 2020 
  * VelosBio expects to announce Phase 1 data for VLS-101 in haematological 
    cancers in H2 2020 
 
Joe Anderson, CEO, commented: 
 
"We remain focused on driving realisable value in our portfolio, and in turn 
our NAV, and I believe we are well positioned to do so through 2020 and beyond. 
We have had a challenging year with our shareholder structure and volatility in 
our public portfolio companies, but look ahead with confidence and see a 
portfolio that is maturing and has the potential to deliver real value." 
 
Conference Call and presentation Information 
 
Arix will host a conference call today, 10 March at 12:15 pm GMT/ 7:15am EST, 
to discuss the company's financial results and operational update. 
 
To listen to the webcast and view the accompanying slide presentation, please 
go to: https://arixbioscience.com/investor-relations/events-presentations 
 
The call may also be accessed by dialling (0)330 336 9125 for U.K. and European 
callers and +1 323-794-2588 for U.S. callers. Please reference conference ID 
4517667. 
 
Enquiries 
 
For more information on Arix, please contact: 
 
Arix Bioscience plc 
Charlotte Parry, Head of Investor Relations 
+44 (0)20 7290 1072 
charlotte@arixbioscience.com 
 
Optimum Strategic Communications 
Mary Clark, Supriya Mathur 
T: +44 (0) 20 3950 9144 
optimum.arix@optimumcomms.com 
 
About Arix Bioscience plc 
 
Arix Bioscience plc is a global venture capital company focused on investing in 
and building breakthrough biotech companies around cutting edge advances in 
life sciences. 
 
We collaborate with exceptional entrepreneurs and provide the capital, 
expertise and global networks to help accelerate their ideas into important new 
treatments for patients. As a listed company, we are able to bring this 
exciting growth phase of our industry to a broader range of investors. 
 
www.arixbioscience.com 
 
Chairman's Statement 
 
Good underlying progress in the portfolio with a focus on unlocking and 
realising value for shareholders in 2020 
 
2019 was a year of both progress and challenge for the Company. 
 
The Arix portfolio now comprises 16 biotech companies addressing serious unmet 
medical need, building on innovative science and led by successful 
entrepreneurs in their respective areas. The portfolio saw positive clinical 
data from four of these companies during the year and three raised additional 
capital at valuation uplifts to the prior round. Harpoon was one of these 
companies, the fourth in our portfolio to successfully list and raise capital 
on Nasdaq. 
 
Our strategic partnerships continue to play an important role in guiding and 
supporting our activities at Arix. We have built a strong dialog with our 
pharmaceutical partners Fosun, Ipsen, Takeda and UCB and benefit from their 
expertise as they also gain access to our pipeline and portfolio of emerging 
biotech companies. Our academic partnerships with Max Planck in Germany and 
Fred Hutch in Seattle are also beginning to bear fruit. Our first company 
incubated from Max Planck, Quench Bio, attracted leading new investors in its 
well supported Series A funding round shortly after year-end. 
 
The portfolio is reaching a point where investors can expect to start to see 
value realisations either through the strategic sale of portfolio companies to 
pharmaceutical or larger biotech companies or through the sale of publicly 
listed holdings. The executive team will be focused on this in 2020 as well as 
attracting additional investment to the company. During 2019, the book value of 
the portfolio was impacted significantly by Autolus, one of our listed 
companies whose stock price was riding high in the early part of the year but 
has come back significantly. However, we do continue to see good progress in 
this company's clinical programmes. 
 
An additional challenge during the year was the suspension in June 2019 of the 
Woodford Equity Income Fund, our largest shareholder with a 19.8% holding in 
Arix. We have been seeking to achieve an orderly transition of this holding to 
long-term supportive investors, and remove the distraction and consequent 
uncertainty that it has had on the share price in recent months. 
 
In the latter part of 2019 the Board held a strategy day to review the 
performance of the company and the portfolio and to agree the outline of a 
three year plan to deliver value for shareholders. We also reviewed options to 
further build the business as value is delivered over the next three years. 
 
From a governance perspective we have also started to build a more London 
centric Board with the skills and experience to guide the company through the 
next few critical years. In particular, Mark Breuer, who joined as a Non 
Executive in 2019 brings broad experience in UK capital markets and in advising 
public company Boards. Naseem Amin, who joined more recently, brings strong 
transatlantic industry experience in clinical development, business development 
and venture capital. With the added industry and financial experience of Giles 
Kerr, deep R&D expertise of Trevor Jones and the successful venture and 
industry track record of Art Pappas, the governance is in place to guide the 
company to take the actions needed to deliver value for shareholders. 
 
I would also like to take this opportunity to thank Franz Humer, James 
Rawlingson and Meghan Fitzgerald for their service as Board members and for 
their important contributions in the formative years as we created and built 
Arix. 
 
Arix has built a portfolio of companies pursuing breakthroughs in treating 
serious diseases for the benefit of patients. To continue this important work I 
look forward to 2020, where we start to achieve cash realisations to reinvest 
in new companies, to attract new investors and to deliver value for 
shareholders. I know Joe Anderson and the team at Arix are up to the challenge 
and have a portfolio that can deliver on this. 
 
Jonathan Peacock 
Chairman 
9 March 2020 
 
Chief Executive Officer's Review 
 
Developing the long term potential of the business 
 
We are working closely with our portfolio companies to build realisable value 
for our shareholders and see multiple clinical and scientific development 
milestones in the year ahead. 
 
We have made good progress since the IPO in February 2017. The portfolio is now 
well-balanced and diverse, with science that is showing significant promise and 
products that have progressed well in clinical trials. To date, we have 
invested GBP138 million in the Gross Portfolio, which was valued at GBP154m by 
year-end, including GBP5 million of realisations. The team at Arix has the right 
blend of experience and talent to make the most of the significant 
opportunities in the portfolio on behalf of shareholders. 
 
Despite this, and disappointingly, during 2019, the results for the period show 
a 25% decline in Net Asset Value (NAV) per share (down 51p per share) compared 
to a positive return of 32% (48p per share) a year earlier. Our results were 
particularly impacted by the volatility of our public stocks, which 
collectively fell by 38% in 2019, giving up strong gains made in the prior 
year. As a result, our reported NAV at year-end was GBP202 million (GBP1.49 per 
share) compared to GBP270 million (GBP2.00 per share) at December 2018. 
 
Most of our portfolio companies were small private companies at the time we 
first invested. As we reported last year, progress has been rapid and four of 
these have already made the transition to public companies following IPOs on 
the Nasdaq. 
 
An IPO is not necessarily an exit point for us, but rather a means for the 
portfolio company to access additional capital from the public markets to speed 
the development of new products through clinical testing. But the development 
of these medicines takes time; it is a competitive business and clinical trials 
in humans, rightly, are highly regulated and set very high standards for 
proving efficacy and safety before approval is achieved for new products to 
treat patients. As a result, public biotech company share prices can be 
volatile in the period between their listing and producing definitive data, as 
was seen with Arix's listed portfolio companies, which made up 44% of our NAV 
at the beginning of the year. 
 
Our view is that such fluctuations, although important to manage to the extent 
they can be, are less relevant to true value creation than is making solid 
progress with clinical development. On that count, during 2019 we saw 
meaningful progress in the clinical development plans of our portfolio 
companies. This is key to securing sustainable uplifts in our NAV and this 
remains our top priority. 
 
During 2019, we have had a particular focus on building start-up companies 
based on cutting edge science to balance our portfolio of later stage 
companies. Company creation involves substantial effort from our team, and 
yields high ownership of the resulting company for relatively modest investment 
of capital. We have started a programme of bringing accomplished life science 
entrepreneurs into Arix to help us with such work and recently the first 
results of this emerged in the shape of STipe, our new portfolio company, led 
by Christian Schetter, Arix Entrepreneur in Residence. Our investment team has 
also been busy helping to build Quench Bio - a company that emerged from 
stealth mode shortly after year-end. We are looking to extend these efforts in 
company creation and as part of this are pleased to have announced the 
appointment of Roberto Iacone as our second Entrepreneur in Residence in March 
2020. 
 
The year ahead 
 
We remain focused on driving realisable value in our portfolio, and in turn our 
NAV, and I believe we are well positioned to do so through 2020 and beyond. 
 
We have had a challenging year with our shareholder structure and volatility in 
our public portfolio companies, which in the near term continues with the 
emergence of a new risk in the form of coronavirus, but look ahead with 
confidence and see a portfolio that is maturing and has the potential to 
deliver real value. 
 
I am privileged to lead such a talented and dedicated team, optimistic about 
the direction in which our business is heading and confident in the long-term 
value Arix can deliver. 
 
Joe Anderson 
Chief Executive Officer 
9 March 2020 
 
Financial Review 
 
Arix's core focus is to invest in and build breakthrough biotech companies, 
whilst maintaining disciplined capital allocation. 
 
2019 has been a year of transition for Arix's finances, during which the Group 
implemented a leaner structure and lower ongoing cost base. Arix's portfolio 
companies have continued to progress, although this year's results are marked 
by volatility in the valuation of Arix's listed investments, which has led to a 
reduction in the Group's net asset value, and a loss for the financial year. 
 
At year-end, net asset value totalled GBP202.1 million, a reduction of GBP68.1 
million compared to 2018's GBP270.2 million. This was predominantly driven by a 
net downward revaluation of Arix's investments of GBP58.6 million in the year 
(2018: GBP51.2 million positive revaluation). 
 
Arix ended the year with cash and deposits of GBP54.6 million (2018: GBP91.2 
million), the reduction predominantly driven by strong investment activity, 
with GBP39.2 million deployed across both new and existing portfolio companies; 
partially offsetting this, some initial modest realisations were seen (GBP8.9 
million of proceeds). 
 
Core Portfolio 
 
Arix added one new company to its Core Portfolio during the year, co-leading 
the $63 million Series B investment into Imara, with a commitment of $15.0 
million (GBP11.3 million). In the first half of the year, Harpoon Therapeutics 
completed its Nasdaq IPO, in which Arix invested a further $6.0 million (GBP4.7 
million); and Aura Biosciences successfully closed a Series D financing round, 
at a 33% uplift to the 2017 Series C, when Arix first invested in the company. 
Autolus Therapeutics also completed a follow-on financing, in April 2019, in 
which Arix invested a further GBP3.8 million. Investment pace slowed during the 
second half of the year, although milestone investments were made into Amplyx 
Pharmaceuticals, Aura Biosciences and Artios Pharma (the latter funded in 
January 2020), in line with existing commitments. 
 
The Core Portfolio incurred a net negative revaluation of GBP54.6 million during 
the year, arising almost exclusively from Arix's listed investments. The 
majority of the impact was from Autolus Therapeutics, with Arix's stake falling 
by GBP50.8 million, compared to a GBP55.9 million positive revaluation in 2018. 
Other notable decreases in the value of listed stakes were seen with LogicBio 
Therapeutics (GBP7.7 million) and Pharmaxis (GBP2.6 million). Arix's stake in 
Harpoon Therapeutics increased in value by GBP6.1 million in the period, while 
the unlisted investments in the Core Portfolio contributed GBP1.9 million. 
 
Shortly prior to year-end, with the stock at all-time highs, Arix realised 11% 
of its stake in Harpoon, at two times the average cost of investment, marking 
the first modest proceeds received from the Core Portfolio. 
 
Discovery Portfolio 
 
Arix holds its earliest stage assets in the Discovery Portfolio. This acts as a 
development pool for some of the most promising emerging areas of biotech, with 
the companies often in the initial stages of research and development. One new 
company was added to this portfolio in the year, as Arix co-led the EUR20 million 
Series A financing of Stipe Therapeutics, committing EUR5.7 million (GBP4.8 
million), for a 19.8% stake. Meanwhile, a decision was taken to wind down 
Mitoconix Bio, in which Arix had invested GBP0.8 million. While it is always 
disappointing when a company does not reach its potential, this highlights 
Arix's risk-based approach, initially committing small amounts of capital split 
into milestone-dependent tranches, meaning cash is preserved when necessary 
levels of conviction are not achieved. 
 
A positive development within the Discovery Portfolio was Quench Bio, which 
emerged from stealth mode shortly after year-end, concluding its Series A 
financing. Arix co-founded the company in 2018, alongside Atlas Venture, 
incubating the investment within the Discovery Portfolio over the past 18 
months. 
 
Other Interests 
 
Arix's Other Interests reflect legacy holdings, which continue to wind down. 
Proceeds of GBP4.3 million were received during the year, while net writedowns of 
GBP4.5 million were recognised; at year-end, the remaining positions total GBP2.7 
million. 
 
Cash Position 
 
Cash and deposits totalled GBP54.6 million at year-end, compared to GBP91.2 million 
the previous year. The reduction in the period was predominantly driven by 
ongoing deployment into Arix's portfolio, with GBP39.2 million invested. This was 
partially offset by the realisation of a portion of Arix's Harpoon holding, and 
by the wind down of Arix's Other Interests, which cumulatively generated GBP8.8 
million of proceeds during the year. 
 
At year-end, amounts committed to portfolio companies, upon completion of 
agreed milestones, totalled GBP8.5 million; this excludes 2019's GBP4.3 million 
investment in Artios, the funds for which were transferred in January 2020. 
Arix continues to take a prudent approach to cash management, reserving funds 
for both the anticipated future requirements of the portfolio and the ongoing 
costs of the business, leaving Arix well placed to continue supporting the 
existing portfolio. 
 
Consolidated Statement of Comprehensive Income 
 
The largest component of Arix's Statement of Comprehensive Income is the change 
in fair value of investments, which reduced by GBP58.6 million in the year (2018: 
increase of GBP51.2 million). The significant movements in this balance are 
discussed on the previous page. 
 
Throughout 2019, Arix has been transitioning to a leaner organisational 
structure and lower cost base. Significant changes were made to the management 
team, with Sir Christopher Evans and James Rawlingson departing, and Jonathan 
Peacock moving to a Non-Executive role. The previously announced premises 
review resulted in the sub-letting of Arix's US office and a move to smaller 
location. Despite incurring a number of one-off costs associated with these 
changes during 2019, Administrative Expenses excluding Depreciation and 
Amortisation were GBP1.5 million lower than the previous year, at GBP9.3 million. 
Arix anticipates that these costs will be below GBP9.0 million in 2020. 
 
As expected, Revenue decreased to GBP0.5 million (2018: GBP1.3 million), reflecting 
The Wales Life Sciences Investment Fund's reducing contribution as the fund 
enters the later years of its life. Interest income of GBP0.8 million (2018: GBP0.7 
million) was earned on Arix's cash and deposits. 
 
Other deductions in the period relate to foreign exchange losses of GBP4.4 
million (2018: GBP4.6 million gain), predominantly arising from Arix's 
increasingly US dollar denominated investment portfolio; a one-off GBP0.5 million 
impairment relating to Arix's sub-let US property; a GBP0.8 million impairment to 
intangible assets; and a share based payment charge of GBP2.8 million (2018: GBP3.3 
million). 
 
Taxation 
 
Movements in Arix's tax balance to date have principally related to deferred 
tax balances. Revaluations in Arix's investments are only taxable once 
realised, but a deferred tax charge is recognised in the same period as an 
unrealised revaluation. Where possible, Arix aims to take advantage of the UK's 
Substantial Shareholding Exemption, which exempts taxable gains or losses 
arising from the disposal of shares, where certain conditions are met. 
 
Valuation Policy 
 
Arix's investments are valued in accordance with International Private Equity 
and Venture Capital Valuation Guidelines December 2018 ('IPEV Guidelines'). 
Quoted investments are marked-to-market at the period end. Unquoted investments 
are valued with reference to the most recent funding round; milestones; or by 
discounted cash flow. 
 
Investment summary 
 
              Investment  Value Investment Realisations Change in       FX  Value    Fully      Fully     Fully 
                         31 Dec  in period    in period Valuation Movement 31 Dec  Diluted Committed,   Funded. 
                             18         GBPm           GBPm        GBPm       GBPm     19   Equity    Not Yet     Fully 
                             GBPm                                                GBPm Interest   Invested   Diluted 
                                                                                        GBPm         GBPm    Equity 
                                                                                                      Interest, 
                                                                                                              % 
 
Core portfolio 
 
Amplyx Pharmaceuticals      3.2        1.9            -         -    (0.2)    4.9     3.0%          -      3.0% 
 
Artios Pharma              10.9        4.3            -         -        -   15.2    12.4%          -     12.4% 
 
Atox Bio                    3.2        3.2            -     (1.2)    (0.2)    5.0     6.4%        0.2      6.5% 
 
Aura Biosciences            3.9        3.4            -       1.2    (0.2)    8.3     7.7%          -      7.7% 
 
Autolus                    81.5        3.8            -    (50.8)    (0.7)   33.8     7.5%          -      7.5% 
 
Harpoon Therapeutics       23.9        4.7        (4.3)       6.1    (1.5)   28.9    10.4%          -     10.4% 
 
Imara                         -        9.3            -       1.4        -   10.7     9.2%        2.1      9.9% 
 
Iterum Therapeutics         4.3          -            -     (0.6)        -    3.7     7.3%          -      7.3% 
 
LogicBio Therapeutics      24.3          -            -     (7.7)    (0.3)   16.3    13.0%          -     13.0% 
 
Pharmaxis                   6.4          -            -     (2.6)    (0.1)    3.7    11.1%          -     11.1% 
 
VelosBio                    5.2          -            -       0.5    (0.2)    5.5     8.9%        3.3     11.3% 
 
Verona Pharma               2.5          -            -     (0.9)        -    1.6     2.5%          -      2.5% 
 
                          169.3       30.6        (4.3)    (54.6)    (3.4)  137.6                 5.6 
 
Discovery portfolio         6.2        5.6        (0.3)       0.5    (0.4)   11.6                 2.9 
 
Gross portfolio           175.5       36.2        (4.6)    (54.1)    (3.8)  149.2                 8.5 
 
Other interests             8.5        3.0        (4.2)     (4.5)    (0.1)    2.7                   - 
 
Total Investments         184.0       39.2        (8.8)    (58.6)    (3.9)  151.9                 8.5 
 
Risk Management 
 
The Group monitors a number of principal risks and uncertainties that may 
impact the business. These include financial, non-financial, internal and 
external concerns. 
 
Risk management framework 
 
The Directors are able to manage the business, and achieve its strategic 
objectives, due to an effective risk management framework which features 
multiple layers. 
 
Board 
 
Managing risk is a key responsibility of the Board, who set a strong tone, in 
line with best practice corporate governance. 
 
Key committees 
 
The Audit and Risk Committee oversees the effectiveness of the risk management 
processes. 
 
The Remuneration Committee ensures incentives and reward are balanced and 
appropriate for achieving the strategy. 
 
The Nomination Committee addresses the need for continuing strength at the 
senior levels of the Company and is responsible for succession planning. 
 
Executive management 
 
The management team is responsible for identifying, assessing and mitigating 
the day-to-day operational risks. 
 
Portfolio Company boards and independent assurance 
 
The boards of our Portfolio Companies are responsible for ensuring they meet 
key commercial objectives, and in this they are typically supported by senior 
members of the Arix Bioscience team, who also sit on their boards. 
 
Independent assurance is provided by industry experts when required. For 
example, external advisors are engaged to provide regulatory compliance support 
to the Board of Arix Capital Management, Arix Bioscience's FCA-regulated fund 
management subsidiary. 
 
Risks and Mitigants 
 
The key risks to Arix have been assessed in light of the current environment; 
these, along with the steps taken by Arix to manage such risks, are detailed 
below. 
 
Area            Risk              Impact                Mitigation 
 
1 Clinical      Arix's portfolio  Negative clinical     Arix has an experienced team 
trial risks     typically         trial read outs may   responsible for identifying 
                comprises         reduce the value of   and developing portfolio 
                companies that    the portfolio         companies, resulting in a high 
                are engaged in    company, potentially  standard of due diligence 
                clinical trials.  to nil. This would    before the commitment of any 
                There is a risk   therefore result in a capital. Post?investment, Arix 
                that the trials   decrease in Arix's    typically has representatives 
                may produce       profitability, and    on the company's board of 
                negative or       reduce Arix's ability directors, ensuring it is 
                inconclusive      to generate positive  fully aware of business 
                results.          cash flows from       developments, and allowing for 
                                  future realisations.  mitigation of possible issues 
                                  Inconclusive read     as they arise. 
                                  outs may both reduce  Arix funds a range of 
                                  the value of the      portfolio companies and 
                                  portfolio company,    continues to develop its 
                                  impacting Arix's      portfolio across a range of 
                                  profitability, and    therapeutic areas. Its diverse 
                                  require further       portfolio means that Arix's 
                                  capital to fund       financial performance is not 
                                  additional trials to  overly reliant on any one 
                                  seek further clarity  business. 
                                  in the results, 
                                  adversely impacting 
                                  Arix's cash flow. 
 
2 Personnel     Arix's success is The financial         Arix's investment team have 
                predicated on the performance of Arix   strong scientific backgrounds 
                quality of its    depends on its        and are experienced life 
                investment        ability to identify   sciences investors. 
                decisions, which  and develop           Arix has a market?appropriate 
                in turn is a      outstanding portfolio remuneration scheme for its 
                product of the    companies and, as     senior employees. This 
                calibre of its    such, is reliant on   includes share incentive 
                investment team.  its key personnel.    schemes, which reward 
                There is a risk   Loss of key           personnel for long?term 
                of Arix being     individuals could     service and performance. 
                unable to attract reduce the quality of Arix has three management 
                or retain staff   Arix's investment     members making up the 
                of sufficient     decision-making and   Executive Committee performing 
                calibre.          therefore negatively  active day?to?day roles who 
                                  affect Arix's         are able to provide emergency 
                                  financial performance cover for each other over a 
                                  and future prospects. short period. 
                                                        Arix's Nomination Committee is 
                                                        responsible for appropriate 
                                                        succession planning. 
 
3 Macroeconomic Adverse market    An economic downturn, Arix's strategy is to deploy 
conditions      conditions may    triggered by          capital into innovative 
                impact Arix's     macroeconomic factors businesses which have unique, 
                operational       or a market shock     high impact outcomes; Arix 
                model.            such as coronavirus,  believes that such businesses 
                                  may reduce            are less susceptible to 
                                  opportunities for     macroeconomic cycles. 
                                  Arix to realise       Arix has funded portfolio 
                                  capital from          companies across a range of 
                                  portfolio companies,  geographies, including the UK, 
                                  affecting cash flow   USA, Europe, Israel and 
                                  and financial         Australia. As such, it is not 
                                  performance if        overly reliant on a downturn 
                                  portfolio valuations  or market shock in a single 
                                  are reduced. The      geography. 
                                  availability of       Arix monitors its availability 
                                  capital for any       of capital closely, ensuring 
                                  external fundraising  sufficient funds are available 
                                  by Arix or its        for the investment and 
                                  portfolio companies   operational needs of the 
                                  may also be affected. business. 
 
4 Legislation & Changes to        A change in           Arix's portfolio is 
regulation      government policy government regulation diversified by geography, with 
                or regulation in  (for example CFIUS in exposure to the UK, USA, 
                the research,     the United States)    Europe, Israel and Australia, 
                healthcare or     may adversely affect  protecting the Group from the 
                life sciences     the profitability of  adverse actions of any one 
                industries could  the healthcare and    government. 
                impact Arix or    life sciences         Arix's corporate team actively 
                its portfolio     industry, resulting   monitors changes to laws and 
                companies.        in a reduction in the regulation, and where 
                                  number of investment  considered necessary enlists 
                                  opportunities,        the advice of relevant experts 
                                  availability of       to consider any company or 
                                  external funding or   portfolio impacts. 
                                  potential exit 
                                  opportunities for 
                                  portfolio companies. 
 
5 Brexit        Brexit may have   Specific impacts      Arix has the ability to 
                an impact beyond  could include:        withstand a depressed capital 
                the risks         a depressed UK        market, including but not 
                described above   capital market that   limited to the ability to 
                in terms of by    does not support the  dispose of a portion of its 
                severity of a     raising of capital    listed investments; withhold 
                downturn or the   for the Group or its  funds that are reserved for 
                nature of the     UK-based portfolio    the existing portfolio; or the 
                impact.           companies; or         ability to issue up to 10% of 
                                  a reduction in        share capital to a new 
                                  government-funded     investor. Arix also closely 
                                  research in biotech,  monitors available capital and 
                                  leading to reduced    holds cash reserves to cover 
                                  investment            future operating costs. 
                                  opportunities.        Both Arix's portfolio and 
                                                        pipeline of future 
                                                        opportunities has a broad 
                                                        geographic spread, with 
                                                        limited exposure to the UK 
                                                        capital market and government 
                                                        policy. As such, its financial 
                                                        performance is not overly 
                                                        reliant on the UK market. 
 
Viability statement 
 
The Board has assessed the prospects of Arix over a period greater than 12 
months. We have considered a period of three years from the balance sheet date, 
as the Board expects the majority of Arix's current commitments and new 
proceeds raised to be committed over the next three years, and therefore 
reflects the period over which the Group's cash flows are assessed internally. 
 
A robust assessment of the principal risks and their mitigants has been carried 
out. The Board assessed Arix's business model, particularly its approach to 
future cash commitments to existing portfolio companies. Key judgements 
reflected how future cash requirements may change from restrictive regulations, 
and how the availability of capital may be impacted from the loss of key 
personnel. 
 
Having initially started with a base case scenario considering Arix's finances 
over the assessment period, the estimated impacts on the Group's cash flow, as 
described above, are modelled, creating a range of adverse scenarios. An 
extreme downside case is then considered, reflecting the estimated cash flow 
impact of all considered risks occuring concurrently. Finally, the analysis 
considers the mitigating actions the Group could take to reduce the financial 
impact of the noted risks. 
 
Based on its review, and the consideration of any changes that had occurred 
post year-end, the Board has a reasonable expectation that Arix will be able to 
continue in operation and meet its liabilities as they fall due over a 
three-year period from the date of this report and confirm that preparing the 
financial statements on a going concern basis is appropriate. 
 
Consolidated statement of comprehensive income 
 
For the year ended 31 December 2019 
 
                                                             Note     2019     2018 
                                                                     GBP'000    GBP'000 
 
Change in fair value of investments                            11 (58,642)   51,173 
 
Revenue                                                         3      506    1,328 
 
Administrative expenses                                         6  (9,709) (11,698) 
 
Operating (loss) / profit                                         (67,845)   40,803 
 
Net finance income                                              7      769      708 
 
Foreign exchange (losses) / gains                                  (4,443)    4,583 
 
Impairment of right-of-use and intangible assets                   (1,259)        - 
 
Share-based payment charge                                     18  (2,790)  (3,333) 
 
(Loss) / profit before taxation                                   (75,568)   42,761 
 
Taxation                                                        9    5,883  (5,883) 
 
(Loss) / profit for the year                                      (69,685)   36,878 
 
Other comprehensive (expense) / income 
 
Exchange differences on translating foreign operations               (185)    1,269 
 
Taxation                                                        9        -        - 
 
Total comprehensive (expense) / income for the year               (69,870)   38,147 
 
Attributable to 
 
Owners of Arix Bioscience plc                                     (69,870)   38,147 
 
Earnings per share 
 
Basic earnings per share (p)                                   10   (53.8)     32.1 
 
Diluted earnings per share (p)                                 10   (53.8)     29.7 
 
The above consolidated statement of comprehensive income should be read in 
conjunction with the accompanying notes. 
 
Consolidated statement of financial position 
 
As at 31 December 2019 
 
                                                             Note     2019     2018 
                                                                     GBP'000    GBP'000 
 
ASSETS 
 
Non-current assets 
 
Investments held at fair value                                 11  151,921  183,981 
 
Intangible assets                                              12      688    1,770 
 
Property, plant and equipment                                  13      160      313 
 
Right of use asset                                                     249        - 
 
Investment property                                                    366        - 
 
                                                                   153,384  186,064 
 
Current assets 
 
Cash and cash equivalents                                      15   54,638   31,009 
 
Cash on long-term deposit                                      15        -   60,209 
 
Trade and other receivables                                    14    1,106    2,174 
 
Right of use asset                                                      90        - 
 
                                                                    55,834   93,392 
 
TOTAL ASSETS                                                       209,218  279,456 
 
LIABILITIES 
 
Current liabilities 
 
Trade and other payables                                       16  (6,154)  (3,399) 
 
Lease liability                                                      (685)        - 
 
Deferred tax liability                                          9        -  (5,883) 
 
                                                                   (6,839)  (9,282) 
 
Non-Current Liabilities 
 
Lease Liability                                                      (271)        - 
 
TOTAL LIABILITIES                                                  (7,110)  (9,282) 
 
NET ASSETS                                                         202,108  270,174 
 
EQUITY 
 
Share capital and share premium                                17  188,585  188,585 
 
Retained earnings                                                   15,718   82,018 
 
Other reserves                                                     (2,195)    (429) 
 
TOTAL EQUITY                                                       202,108  270,174 
 
The accompanying notes form an integral part of the financial statements. The 
financial statements were approved by the Board of Directors and authorised for 
issue on 9 March 2020, and were signed on its behalf by 
 
Joe Anderson 
 
Chief Executive Officer 
 
Consolidated statement of changes in equity 
 
For the year 31 December 2019 
 
                                           Share    Other    Other Retained    Total 
                                         Capital   Equity Reserves Earnings    GBP'000 
                                             and    GBP'000    GBP'000    GBP'000 
                                         Premium 
                                           GBP'000 
 
As at 1 January 2019                     188,585  (1,211)      782   82,018  270,174 
 
Loss for the year                              -        -        - (69,685) (69,685) 
 
Other comprehensive (expense)/income           -        -    (780)      595    (185) 
 
Share-based payment charge                     -        -        -    2,790    2,790 
 
Acquisition of own shares                      -    (986)        -        -    (986) 
 
Issue of own shares to employees               -      443    (443)        -        - 
 
As at 31 December 2019                   188,585  (1,754)    (441)   15,718  202,108 
 
For the year ended 31 December 2018 
 
                                           Share    Other    Other Retained    Total 
                                         Capital   Equity Reserves Earnings    GBP'000 
                                             and    GBP'000    GBP'000    GBP'000 
                                         Premium 
                                           GBP'000 
 
As at 1 January 2018                     105,125        -    (768)   42,088  146,445 
 
Profit for the year                            -        -        -   36,878   36,878 
 
Other comprehensive income                     -        -    1,550    (281)    1,269 
 
Contributions of equity, net of           83,460        -        -        -   83,460 
transaction costs and tax 
 
Share-based payment charge                     -        -        -    3,333    3,333 
 
Acquisition of own shares                      -  (1,211)        -        -  (1,211) 
 
Issue of own shares to employees               -        -        -        -        - 
 
As at 31 December 2018                   188,585  (1,211)      782   82,018  270,174 
 
Consolidated statement of cash flows 
 
For the year ended 31 December 2019 
 
                                                             Note     2019      2018 
                                                                     GBP'000     GBP'000 
 
Net cash from operating activities                             19  (9,242)  (11,018) 
 
Finance income                                                         769         - 
 
Finance expenses                                                         -      (12) 
 
Tax paid                                                                 -      (28) 
 
Net cash from operating activities                                 (8,473)  (11,058) 
 
Cash flows from investing activities 
 
Purchase of equity investments                                    (34,858)  (55,228) 
 
Disposal of equity and loan investments                              8,791         - 
 
Purchase of property, plant and equipment                              (6)       (2) 
 
Net cash received from / (placed on) long-term deposit              60,209  (60,209) 
 
Net cash from investing activities                                  34,136 (115,439) 
 
Cash flows from financing activities 
 
Net proceeds from issue of shares                                        -    83,460 
 
Purchase of own shares by Employee Benefit Trust                     (986)   (1,211) 
 
Net cash from financing activities                                   (986)    82,249 
 
Net increase/(decrease) in cash and cash equivalents                24,677  (44,248) 
 
Cash and cash equivalents at start of year                          31,009    74,938 
 
Effect of exchange rate changes                                    (1,048)       319 
 
Cash and cash equivalents at end of year                            54,638    31,009 
 
Notes to the financial statements 
 
1. General Information 
 
The principal activity of Arix Bioscience plc (the 'Company') and its 
subsidiaries (together the 'Arix Group' or 'the Group') is to invest in and 
build breakthrough biotech companies around cutting edge advances in life 
sciences. 
 
The Company is incorporated and domiciled in the United Kingdom. Arix 
Bioscience plc was incorporated on 15 September 2015 as Perceptive Bioscience 
Investments Limited and changed its name to Arix Bioscience Limited. It 
subsequently re-registered as a public limited company and changed its name to 
Arix Bioscience plc. The address of its registered office is 20 Berkeley 
Square, London, W1J 6EQ. The registered number is 09777975. 
 
2. Accounting Policies 
 
A. Basis of preparation 
 
The consolidated financial statements of the Arix Group have been prepared in 
accordance with International Financial Reporting Standards (IFRS) and 
interpretations issued by the IFRS Interpretations Committee (IFRS IC) 
applicable to companies reporting under IFRS as adopted by the European Union. 
The financial statements comply with IFRS as issued by the International 
Accounting Standards Board (IASB) as adopted by the European Union. 
 
The financial statements have been prepared on a historical cost basis, except 
for certain financial assets which have been measured at fair value. The 
financial statements are presented in British pounds sterling, which is the 
functional and presentational currency of the Company, and the presentational 
currency of the Group; balances are presented in thousands of British pounds 
sterling unless otherwise stated. 
 
The Arix Group has applied all standards and interpretations issued by the IASB 
that were effective at the period end date. The accounting policies set out 
below have, unless otherwise stated, been applied consistently to all periods 
presented. 
 
Use of judgements and estimates 
 
In preparing these financial statements, management has made judgements, 
estimates and assumptions that affect the application of the Arix Group's 
accounting policies and reported amounts of assets, liabilities, income and 
expenses. Actual results may differ from those estimates. 
 
Estimates and underlying assumptions are reviewed on an ongoing basis. 
Revisions to estimates are recognised prospectively. 
 
Significant estimates are made by the Arix Group when determining the 
appropriate methodology for valuing investments (see Note 2(i)) and share-based 
payments (see Note 2(o) and Note 18). 
 
In preparing these financial statements, the Directors have considered the 
relationship that the Group has with The Wales Life Sciences Investment Fund 
(the "WLSIF") and specifically as to whether the Group controls WLSIF. The 
Directors note that while Arix Capital Management Limited (a 100% subsidiary of 
Arix Bioscience plc), in its role as fund manager to WLSIF, and Arthurian Life 
Sciences SPV GP Limited (a 100% subsidiary of Arix Bioscience plc) in its role 
as general partner of the WLSIF, both exercise power over the activities of 
WLSIF, they do not have sufficient exposure to variability of returns from 
WLSIF to meet the definition of control and therefore acts as agents, rather 
than principals of WLSIF. Accordingly, WLSIF has not been consolidated into 
these financial statements. 
 
B. Basis of consolidation 
 
Subsidiaries 
 
Subsidiaries are entities over which the Arix Group has control. The Arix Group 
controls an entity when it is exposed to, or has the right to, variable returns 
from its involvement with the entity and has the ability to affect those 
returns through its power over the entity. Subsidiaries are fully consolidated 
from the date on which control is transferred. They are deconsolidated from the 
date that control ceases. The acquisition method of accounting is used to 
account for business combinations by the Group. 
 
The consolidated financial statements comprise a consolidation of the 
subsidiary entities listed below. This table contains the disclosures required 
by Section 409 of the Companies Act 2006 for subsidiaries. 
 
Entity                       Country of    Registered Address               Ownership 
                             Incorporation 
 
Arix Bioscience Holdings     England and   20 Berkeley Square, London, W1J  100% 
Limited                      Wales         6EQ 
 
Arix Bioscience, Inc         United States 214 West 29th Street, 2nd Floor, 100% 
                                           New York NY 10001 
 
Arix Capital Management      England and   Sophia House, 28 Cathedral Road, 100% 
Limited                      Wales         Cardiff, CF11 9LJ 
 
Arthurian Life Sciences GP   Scotland      16 Charlotte Square, Edinburgh,  100% 
Limited                                    EH2 4DF 
 
ALS SPV Limited              England and   20 Berkeley Square, London, W1J  100% 
                             Wales         6EQ 
 
Arthurian Life Sciences SPV  England and   Sophia House, 28 Cathedral Road, 100% 
GP Limited                   Wales         Cardiff, CF11 9LJ 
 
Arix Bioscience plc Employee Jersey        26 New Street, St Helier,        100% 
Benefit Trust                              Jersey, JE2 3RA 
 
Arthurian Life Sciences      Scotland      16 Charlotte Square, Edinburgh,  100% 
Carried Interest Partner LP                EH2 4DF 
 
Arix Bioscience Pty Limited* Australia     Level 27, AMP Centre, 50 Bridge  100% 
                                           Street, Sydney NSW 2000 
 
All companies are involved in investing in and building breakthrough biotech 
companies around cutting edge advances in life sciences, other than Arix 
Capital Management and the Arthurian Life Sciences companies, which are engaged 
in fund management activity, and Arthurian Life Sciences Carried Interest 
Partner LP, which holds a financial interest in a limited partnership. 
 
*Arix Bioscience Pty Limited, a dormant company, was deregistered on 8 January 
2020. 
 
Intercompany transactions, balances and unrealised gains on transactions 
between Group companies are eliminated. Unrealised losses are also eliminated 
unless the transaction provides evidence of an impairment of the transferred 
asset. 
 
Associates 
 
Associates are entities over which the Group has significant influence, but 
does not control, generally accompanied by a shareholding of between 20% and 
50% of the voting rights. 
 
No associates are presented on the Statement of Financial Position as the Group 
elects to hold such investments at fair value through profit and loss. This 
treatment is permitted by IAS 28 Investment in Associates and Joint Ventures, 
which permits investments held by entities that are akin to venture capital 
organisations to be excluded from its measurement methodology requirements 
where those investments are designated, upon initial recognition, at fair value 
through profit or loss and accounted for in accordance with IFRS 9 Financial 
Instruments. Changes in fair value of associates are recognised in the 
Statement of Comprehensive Income in the period in which the change occurs. The 
Group has no interests in associates through which it carries on its business. 
 
The disclosures required by Section 409 of the Companies Act 2006 for 
associated undertakings are included in Note 11 to the financial statements. 
Similarly, those investments which may not have qualified as an associate but 
fall within the wider scope of significant holdings and so are subject to 
Section 409 disclosure acts are also included in Note 11 to the financial 
statements. 
 
WLSIF is considered neither a subsidiary nor an associate, as detailed in Note 
2(a). 
 
C. Adoption of new and revised standards 
 
Certain new accounting standards and interpretations have been applied by the 
Group from 1 January 2019. The Group's assessment of the impact of these new 
standards and interpretations is set out below. 
 
IFRS16 'Leases' 
 
The Group has adopted IFRS 16 Leases retrospectively from 1 January 2019, but 
has not restated comparatives for the 2018 reporting period, as permitted under 
the specific transitional provisions in the standard. The reclassifications and 
the adjustments arising from the new leasing rules are therefore recognised in 
the opening balance sheet on 1 January 2019. 
 
On adoption of IFRS 16, the Group recognised lease liabilities in relation to 
leases which had previously been classified as 'operating leases' under the 
principles of IAS 17 Leases. These liabilities were measured at the present 
value of the remaining lease payments. Right of use assets were measured at the 
amount equal to the lease liability. There were no onerous lease contracts that 
would have required an adjustment to the right of use assets at the date of 
initial application, although one right of use asset has subsequently been 
impaired, in line with IFRS 16. 
 
Assessment for Impairment and Resulting Investment Property 
 
The Group has assessed its right of use assets for impairment, in line with IAS 
36 Impairment of Assets. During the year, the Group vacated its New York office 
at 250 West 55th Street, and has sub-let that space. The right of use asset at 
250 West 55th Street has therefore been impaired to its fair value, being the 
expected proceeds to the Group from sub-letting. As the property no longer 
contributes to the Group's core business and is able to produce its own 
independent cash flows it is considered its own cash generating unit, and is 
therefore required to be classified as an investment property in line with IAS 
40 Investment Property. The property is held at its fair value, being the 
expected proceeds to the Group from sub-letting. 
 
D. Revenue recognition 
 
Revenue is generated from fund management fees, and from Non-Executive 
Directors' fees. Fund management fees are earned as a percentage of funds 
managed and are recognised in the period in which these services are provided. 
Non-Executive Directors' fees are recognised on an accruals basis. 
 
E. Foreign currency translation 
 
The assets and liabilities of foreign operations are translated to Group's 
presentational currency (British pounds sterling) at foreign exchange rates 
ruling at the period-end date. The revenues and expenses of foreign operations 
are translated at an average rate for the period where this rate approximates 
to the foreign exchange rates ruling at the dates of the transactions. Exchange 
differences arising from this translation of foreign operations are reported as 
an item of other comprehensive income and accumulated in the translation 
reserve. 
 
F. Leases 
 
As explained in Note 2(c) above, the Group has changed its accounting policy 
for leases. Until 31 December 2018, leases of the Group's premises were 
classified as as operating leases. Rents payable under operating leases were 
charged against income on a straight-line basis over the lease term, even if 
payments were not made on such a basis. 
 
G. Exceptional items 
 
Items that are material in size and unusual in nature are disclosed separately 
to provide a more accurate indication of underlying performance. 
 
H. Property, plant and equipment 
 
Property, plant and equipment is stated at cost less accumulated depreciation 
and any accumulated impairment losses. Cost includes expenditure that is 
directly attributable to the acquisition of the asset. 
 
Depreciation is calculated using the straight-line method over the estimated 
useful lives of the related assets: 
 
Office equipment                       Three years 
 
Fixtures and fittings                   Five years 
 
Office furniture                          Five years 
 
Leasehold property                   Five years 
 
I. Financial assets 
 
The Arix Group classifies its financial assets as either at fair value through 
profit or loss or amortised cost. The classification depends on the purpose for 
which the financial assets have been acquired and is determined on initial 
recognition. 
 
Amortised cost assets are non-derivative financial assets with fixed or 
determinable payments that are not quoted in an active market. They are 
included in current assets, except for maturities greater than 12 months after 
the end of the reporting period, which are classified as non-current assets. 
The Arix Group's loans and receivables comprise trade and other receivables and 
cash and cash equivalents in the Consolidated Statement of Financial Position. 
 
Regular purchases and sales of financial assets are recognised on the trade 
date - the date on which the Arix Group commits to purchase or sell the asset. 
Financial assets are derecognised when the rights to receive cash flows from 
the investments have expired or have been transferred and the Arix Group has 
transferred substantially all risks and rewards of ownership. 
 
Equity investments 
 
Those investments in the Arix Group that are held with a view to the ultimate 
realisation of capital gains are recognised as equity investments within the 
scope of IFRS 9 and are classified as financial assets at fair value through 
profit or loss. This includes investments in associated undertakings, as per 
Note 11. When financial assets are initially recognised they are measured at 
fair value. They are subsequently remeasured at their fair value if a valuation 
event occurs. 
 
Valuation of investments 
 
The fair value of the Group's investments is determined using International 
Private Equity and Venture Capital Valuation Guidelines December 2018 ('IPEV 
Guidelines'), which comply with IFRS. 
 
The fair value of quoted investments is based on bid prices at the period end 
date. 
 
Upon investment, the fair value of unlisted securities is recognised at cost. 
Similarly, following a further funding round with participation by at least one 
third party, the price of the funding round is generally considered to 
represent the investment's fair value at the transaction date, although the 
specific terms and circumstances of each funding round must always be 
considered. 
 
Following the transaction date, each investment is observed for objective 
evidence of an increase or impairment in its value. This reflects the fact that 
investments made in seed, start-up and early stage biotech companies often have 
no current and no short-term future revenues or positive cash flows; in such 
circumstances, it can be difficult to gauge the probability and financial 
impact of the success or failure of development or research activities and to 
make reliable cash flow forecasts. As such, the Group carries out an enhanced 
assessment based on milestone analysis, which seeks to determine whether there 
is an indication of a change in fair value based on changes to the company's 
prospects. A milestone event may include, but is not limited to, technical 
measures, such as clinical trial progress; financial measures, such as a 
company's availability of cash; and market measures, such as licensing 
agreements agreed by the company. Indicators of impairment might include 
significant delays to clinical progress, technical complications or financial 
difficulties. Often qualitative milestones provide a directional indication of 
the movement of fair value. Calibrating such milestones may result in a fair 
value equal to the transaction value. Any ultimate change in valuation reflects 
the assessed impact of the progress against milestones and the consequential 
impact on a potential future external valuation point, such as a future funding 
round or initial public offering. 
 
When forming a view of the fair value of its investment, the Arix Group takes 
into account circumstances where an investment's equity structure involves 
different class rights on a sale or liquidity event. 
 
The valuation metrics used in these financial statements are discussed in Note 
11. 
 
Although the Directors use their best judgement, there are inherent limitations 
in any valuation techniques. Whilst fair value estimates presented herein 
attempt to present the amount the Arix Group could realise in a current 
transaction, the final realisation may be different, as future events will also 
affect the current estimates of fair value. The effects of such events on the 
estimates of fair value, including the ultimate realisation of investments, 
could be material to the financial statements. 
 
Treatment of gains and losses arising on fair value 
 
Realised and unrealised gains and losses on financial assets at fair value 
through profit and loss are included in the Statement of Comprehensive Income 
in the period in which they arise. 
 
Recognition of financial assets 
 
Purchases and sales of financial assets are recognised on trade-date, the date 
on which the Group commits to purchase or sell the asset. Financial assets are 
derecognised when the rights to receive cash flows from the financial assets 
have expired or have been transferred and the Group has transferred 
substantially all the risks and rewards of ownership. 
 
Loans and receivables are subsequently carried at amortised cost using the 
effective interest method. 
 
Impairment of financial assets 
 
At the end of each reporting period the Group assesses whether there is 
objective evidence that its loans and other receivables are impaired. The 
amount of the loss is measured as the difference between the asset's carrying 
amount and the present value of estimated future cash flows discounted at the 
financial asset's original effective interest rate. The asset's carrying amount 
is reduced through the use of an allowance account and the amount of the loss 
is recognised in the Statement of Comprehensive Income within administrative 
expenses. If, in a subsequent period, the amount of the impairment loss 
decreases and the decrease can be related objectively to an event occurring 
after the impairment was recognised, the reversal of the previously recognised 
impairment loss is recognised in the Statement of Comprehensive Income within 
administrative expenses. The Group's financial assets that are subject to IFRS 
9's expected credit loss model are its loans and receivables, cash and cash 
equivalents and cash on long term deposit. The identified impairment loss is 
considered immaterial. 
 
Financial assets and liabilities are offset when there is a legally enforceable 
right to offset the recognised amounts and there is an intention to settle on a 
net basis, or realise the asset and settle the liability simultaneously. The 
legally enforceable right must not be contingent on future events and must be 
enforceable in the normal course of business and in the event of default, 
insolvency or bankruptcy of the Arix Group or the counterparty. Where these 
conditions are met, the net amount is reported in the Statement of Financial 
Position. 
 
J. Cash and cash equivalents and Cash on long-term deposit 
 
Cash and cash equivalents comprise cash at bank and in hand, call deposits and 
bank overdrafts. Cash on long-term deposit comprises cash held on term deposit 
for a period of at least three months. 
 
K. Goodwill and intangible assets 
 
Intangibles were acquired by the Arix Group as part of the acquisition of Arix 
Capital Management Limited and Arthurian Life Sciences SPV GP Limited. 
 
It is the policy of the Arix Group to amortise these fair values over the 
period in which the Arix Group is expected to obtain economic benefit from the 
related intangible assets. The excess of consideration transferred over the 
fair value of net identifiable assets acquired is recorded as goodwill. If 
those amounts are less than the fair value of the net identifiable assets of 
the business acquired, the difference is recognised directly in the Statement 
of Comprehensive Income as a bargain purchase. The asset is assessed for 
impairment periodically and marked down appropriately if an indication of 
impairment is noted. 
 
L. Share capital 
 
Ordinary shares and Series C Shares are classified as equity. Equity 
instruments issued by the Arix Group are recorded at the proceeds received, net 
of direct issue costs. 
 
Own shares represent shares of Arix Bioscience plc that are held by an employee 
share trust for the purpose of fulfilling obligations in respect of various 
employee share plans. Own shares are treated as a deduction from equity until 
the shares are cancelled, reissued or disposed of. When they vest, they are 
transferred from own shares to retained earnings at their weighted average 
cost. 
 
M. Trade payables 
 
Trade payables are obligations to pay for goods or services that have been 
acquired in the ordinary course of business from suppliers. Accounts payable 
are classified as current liabilities if payment is due within one year or less 
(or in the normal operating cycle of the business if longer). 
 
If not, they are presented as non-current liabilities. 
 
Trade payables are initially recognised at fair value, generally being the 
invoiced amount and are subsequently measured at amortised cost, using the 
effective interest method. 
 
N. Current and deferred taxation 
 
The tax expense for the year comprises deferred tax. Tax is recognised in the 
Statement of Comprehensive Income, except to the extent that it relates to 
items recognised directly in equity. 
 
The current income tax charge is calculated on the basis of the tax laws 
enacted or substantively enacted at the balance sheet date in the countries 
where the Arix Group operates and generates taxable income. Management 
periodically evaluates positions taken in tax returns with respect to 
situations in which applicable tax regulation is subject to interpretation. It 
establishes provisions where appropriate on the basis of amounts expected to be 
paid to the tax authorities. 
 
Deferred income tax is recognised on temporary differences arising between the 
tax bases of assets and liabilities and their carrying amounts in the balance 
sheets, using the liability method. However, the deferred income tax is not 
accounted for if it arises from initial recognition of an asset or liability in 
a transaction other than a business combination that at the time of the 
transaction affects neither accounting nor taxable profit or loss. Deferred 
income tax is determined using tax rates (and laws) that have been enacted or 
substantially enacted by the Statement of Financial Position date and are 
expected to apply when the related deferred income tax asset is realised or the 
deferred income tax liability is settled. 
 
Deferred income tax assets are recognised only to the extent that it is 
probable that future taxable profit will be available against which the 
temporary differences can be utilised. 
 
Deferred income tax assets and liabilities are offset when there is a legally 
enforceable right to offset current tax assets against current tax liabilities 
and when the deferred income tax assets and liabilities relate to income taxes 
levied by the same taxation authority on either the taxable entity or different 
taxable entities where there is an intention to settle the balances on a net 
basis. 
 
O. Share-based payments 
 
The Arix Group operates an equity incentive plan and an executive share option 
plan in which the Group's founders also participate. Share options must be 
measured at fair value and recognised as an expense in the Statement of 
Comprehensive Income with a corresponding increase in equity. The fair value of 
the option is estimated at the date of grant using a Black-Scholes Model or 
Monte Carlo simulation and is charged as an expense in the Statement of 
Comprehensive Income over the vesting period. Where relevant, the charge is 
adjusted each year to reflect the expected and actual level of vesting. 
Estimation uncertainty arises with this balance as the calculation incorporates 
assumptions for share price, exercise price, expected volatility (based on 
similar quoted companies), risk-free interest rate and share option term. 
Further detail on Share-based Payments is available in Note 18. 
 
P. Financial risk management 
 
The Arix Group is exposed to market risk, interest rate risk, credit risk and 
liquidity risk. The senior management oversees the management of these risks 
and ensures that the financial risk taking is governed by appropriate policies 
and procedures and that financial risks are identified, measured and managed in 
accordance with the Arix Group's policies and risk appetite. 
 
The Board of Directors review and agree the policies for managing each of these 
risks, which are summarised below: 
 
Market risk 
 
Foreign exchange risk - the Arix Group operates internationally and is exposed 
to foreign exchange risk arising from various currency exposures, primarily 
with respect to the US dollar and euros. Foreign exchange risk arises from 
future commercial transactions, recognised assets and liabilities and net 
investments in foreign operations. The Arix Group has certain investments whose 
net assets are exposed to foreign currency translation risk; at period-end the 
Arix Group held US dollar-denominated assets valued at $126.5m; 
euro-denominated assets valued at EUR4.7m; Canadian dollar-denominated assets 
valued at C$0.2m; and Australian dollar-denominated assets valued at A$7.0m. A 
10% appreciation in each currency would have a GBP9.4m negative impact on Arix's 
Income Statement; a 10% depreciation would have a GBP11.5m positive impact on 
Arix's income statement. The impact of foreign exchange on these holdings is 
closely monitored. 
 
Price risk - the Arix Group is exposed to equity securities price risk because 
investments are held at fair value through profit or loss. 
 
The Group's strategy is to deploy long term capital into innovative companies 
which have novel, high-impact outcomes; Arix believes that such companies are 
less susceptible to macroeconomic cycles. The Group monitors the availability 
of its capital closely, ensuring sufficient balances are available for the 
continuing operation of the business throughout the period assessed in the 
viability statement. 
 
Interest rate risk 
 
Cash flow interest rate risk is the risk that the future cash flows of a 
financial instrument will fluctuate because of changes in market interest 
rates. Fair value interest rate risk is the risk that the fair value of a 
financial instrument will fluctuate due to changes in market interest rates. 
 
The Arix Group's income is substantially independent of changes in market 
interest rates. Interest-bearing assets include only cash and cash equivalents, 
which earn interest at variable rates. The Arix Group has a treasury policy to 
manage cash and cash equivalents. In the year ended 31 December 2019, a 10% 
change in underlying interest rates would have impacted Arix's Finance Income 
by GBP71k. 
 
Credit risk 
 
Credit risk refers to the risk that a counterparty will default on its 
contractual obligations resulting in financial loss to the Arix Group. The 
major classes of financial assets of the Arix Group are cash and cash 
equivalents (GBP54.6m (2018: GBP31.0m)); cash on long-term deposit (GBPnil (2018: GBP 
60.2m)); and trade and other receivables (GBP1.1m (2018: GBP2.2m)). 
 
Risk of counterparty default arising on cash and cash equivalents is controlled 
within a framework of dealing with high-quality institutions. 
 
As at 31 December 2019, 100% of cash and cash equivalents and cash on long-term 
deposit was deposited with institutions that have a credit rating of at least 
category A+, according to Fitch ratings. 
 
No counterparty has failed to meet its obligations over the period. The maximum 
exposure to credit risk is represented by the carrying amount of each asset. 
Management does not expect any significant counterparty to fail to meet its 
obligations. 
 
Liquidity risk 
 
The Arix Group manages liquidity risk by maintaining sufficient cash to enable 
it to meet its operational requirements. The following table details the 
Group's remaining contractual maturity for its financial liabilities based on 
undiscounted contractual payments: 
 
                                                                    Within    Total 
                                                                  one year    GBP'000 
                                                                     GBP'000 
 
Trade, Other Payables and Accruals (excluding                        6,154    6,154 
non-financial liabilities) 
 
Capital risk management 
 
The Arix Group manages its capital to ensure that it will be able to continue 
as a going concern, whilst also maximising the operating potential of the 
business. The capital structure of the Arix Group consists of equity 
attributable to equity holders of the Arix Group, comprising issued capital and 
retained earnings as disclosed in the Consolidated Statement of Changes in 
Equity. The Arix Group is not subject to externally imposed capital 
requirements. 
 
3. Revenue 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Fund management fee income                                             480      866 
 
Other income                                                            26      462 
 
                                                                       506    1,328 
 
The total revenue for the Arix Group has been derived from its principal 
activity of investing in and building breakthrough biotech companies around 
cutting edge advances in life sciences. All of this revenue relates to trading 
undertaken in the United Kingdom. 
 
4. Segmental Information 
 
Information for the purposes of resource allocation and assessment of 
performance is reported to the Arix Group's Chief Executive Officer, who is 
considered to be the chief operating decision maker, based wholly on the 
overall activities of the Arix Group. Although Arix makes investments globally, 
these are considered by one Investment Committee and reported internally as a 
single portfolio.  It has therefore been determined that the Arix Group has 
only one reportable segment under IFRS 8 ('Operating Segments'), which is that 
of sourcing, financing and developing healthcare and life science businesses 
globally. The Arix Group's revenue, results and assets for this one reportable 
segment can be determined by reference to the Consolidated Statement of 
Comprehensive Income and Consolidated Statement of Financial Position. 
 
5. (Loss)/Profit Before Taxation 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Amortisation                                                         (287)    (287) 
 
Depreciation                                                         (159)    (216) 
 
Impairment of right of use asset                                     (464)        - 
 
Impairment of intangible asset                                       (795)        - 
 
Auditors' remuneration 
 
Statutory audit services 
 
Fees payable for the audit of the Arix Group accounts                  141      135 
 
Fees payable for the audit of the accounts of                           48       40 
subsidiaries of the Arix Group 
 
Non-audit services 
 
Other assurance and advisory services                                   36      195 
 
Total auditors' remuneration                                           225      370 
 
Non-audit services in the year relate to the Arix Bioscience plc interim review 
(GBP30k) and an FCA Client Asset Report (GBP6k) (2018: capital raise GBP150k; 
remuneration advice GBP10k; interim review GBP29k; FCA Client Asset Report GBP6k). 
 
6. Administrative Expenses 
 
The administrative expenses charge broken down by nature is as follows: 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Employment costs                                                     5,637    6,537 
 
Recruitment costs                                                      147      563 
 
Consultancy fees                                                       320      512 
 
Other expenses                                                       3,605    4,086 
 
                                                                     9,709   11,698 
 
7. Net Finance Income/(Expenses) 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Bank interest                                                          769      720 
 
Bank charges                                                             -     (12) 
 
                                                                       769      708 
 
8. Employee Costs 
 
Employee costs (including Directors) comprise: 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Salary and bonus                                                     4,808    5,651 
 
Social security costs                                                  532      580 
 
Pension and benefits costs                                             297      306 
 
                                                                     5,637    6,537 
 
9. Income Tax 
 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Current year tax charge 
 
Current tax                                                              -        - 
 
Deferred tax - current year                                        (5,760)    6,665 
 
Deferred tax - effect of change in tax rates                           687    (782) 
 
Adjustment in respect of previous periods                            (810)        - 
 
Total tax (credit) / charge                                        (5,883)    5,883 
 
Reconciliation of tax charge 
 
(Loss) / profit before tax                                        (75,568)   42,761 
 
Expected tax based on 19.00% (2018: 19.00%)                       (14,358)    8,124 
 
Effects of: 
 
Expenses not deductible for tax purposes                            12,120    3,101 
 
Adjustment in respect of previous periods                            (810)        - 
 
Income not taxable                                                 (9,808)  (2,926) 
 
Impact of rate between deferred tax and current tax                    693    (777) 
 
Recognition of items previously not recognised                           -  (2,646) 
 
Net gains / (losses)                                                   (6)        - 
 
Employee share options                                                 116       23 
 
Deferred tax not recognised                                          6,170      984 
 
Total tax (credit) / charge                                        (5,883)    5,883 
 
Recognised deferred tax provisions 
 
Brought forward                                                      5,883        - 
 
Relating to Profit and loss                                        (5,883)    5,883 
 
Relating to Other comprehensive income                                   -        - 
 
Carried forward                                                          -    5,883 
 
Represented by: 
 
Unutilised tax losses                                                  (8)  (2,835) 
 
ACAs                                                                     -     (17) 
 
Intangibles                                                            276      325 
 
Employee benefits                                                    (276)    (373) 
 
Investments                                                              9    8,784 
 
Other timing differences                                               (1)      (1) 
 
                                                                         -    5,883 
 
Unrecognised deferred tax provisions 
 
Unutilised tax losses                                              (5,263)    (996) 
 
Priority profit share outstanding                                       69        - 
 
Other timing differences                                             (299)        - 
 
                                                                   (5,493)    (996) 
 
10. (Loss)/Earnings per Share 
 
On 4 January 2019, the Group issued 114,358 ordinary shares, in relation to 
certain share awards. On 1 May 2019, 530,000 shares were issued, in relation to 
certain share awards. On 2 July 2019, 84,249 shares were issued, in relation to 
certain share awards. As at 31 December 2019, the Group had 135,551,850 
ordinary shares in issue (2018: 134,823,243). 
 
At the year-end date, 5,080,582 of the ordinary shares were subject to 
restrictions. These shares are not entitled to vote, attend meetings or to 
receive dividends or other distributions. Consequently, restricted shares have 
been excluded from the calculation of the weighted average number of shares in 
issue. 
 
Basic earnings per share is calculated by dividing the profit attributable to 
equity holders of Arix Bioscience plc by the weighted average number of 
enfranchised shares (as adjusted for capital subscription in accordance with 
the terms of the restrictive share agreement) in issue during the period. 
 
No adjustment has been made to the basic loss per share in the year ended 31 
December 2019, as the exercise of share options would have the effect of 
reducing the loss per ordinary share, and therefore is not dilutive. 
Potentially dilutive ordinary shares relate to contingently issuable shares 
arising under the Group's Executive Incentive Plan. 
 
                                                                     As at       As at 
                                                               31 December 31 December 
                                                                      2019        2018 
                                                                     GBP'000       GBP'000 
 
(Loss)/profit attributable to equity holders of Arix              (69,870)      38,147 
Bioscience plc 
 
Weighted average number of shares in issue for the             129,948,773 118,787,412 
purposes of basic earnings per share 
 
Weighted average number of shares in issue for the             129,948,773 128,521,402 
purposes of diluted earnings per share 
 
Basic (loss)/earnings per share                                    (53.8p)       32.1p 
 
Diluted (loss)/earnings per share                                  (53.8p)       29.7p 
 
11. Investments 
 
Equity Investments 
 
                                                           Level 1 -   Level 3 -    Total 
                                                              Quoted    Unquoted    GBP'000 
                                                         Investments Investments 
                                                               GBP'000       GBP'000 
 
At 1 January 2019                                            118,982      64,999  183,981 
 
Additions                                                      8,485      30,681   39,166 
 
Disposals                                                    (4,277)     (4,514)  (8,791) 
 
Transfers                                                     23,131    (23,131)        - 
 
Unrealised (loss)/gain on investments                       (56,475)     (2,167) (58,642) 
 
Foreign exchange losses                                      (2,002)     (1,791)  (3,793) 
 
At 31 December 2019                                           87,844      64,077  151,921 
 
Transfers from Level 3 to Level 1 reflects companies which have listed during 
the year. Level 3 investments are valued with reference to either the most 
recent funding round (GBP37.6m, 2018: GBP33.4m); net asset value (GBP1.4m, 2018: GBP 
4.5m); market-based write-up (GBP22.7m, 2018: GBP23.8m); discretionary write-down 
(GBP2.4m, 2018: GBP3.2m); or by discounted cash flow (GBPnil, 2018: GBPnil). See Note 2 
(I) for further details on the valuation of Level 3 investments. 
 
As permitted by IAS 28 'Investment in Associates' and in accordance with the 
Arix Group accounting policy, investments are held at fair value even though 
the Arix Group may have significant influence over the companies. Significant 
influence is determined to exist when the Group holds more than 20% of the 
holding or when less than 20% is held but in combination with a certain level 
of board representation is deemed to be able to exert significant influence. As 
at 31 December 2019, the Arix Group is deemed to have significant influence 
over the following entities: 
 
Company           Country of    Registered          % of   Net Assets/  Profit/       Date of 
                  Incorporation Address           Issued (Liabilities)   (Loss)     Financial 
                                                   Share    of Company       of   Information 
                                                 Capital                Company 
                                                    Held 
 
Depixus SAS (EUR) France        3-5 Impasse        20.7%         1,948  (1,439)   31 December 
                                Reille, 75014                                            2017 
                                Paris 
 
Quench Bio, Inc   USA           400                32.4%           N/A      N/A  Not publicly 
(USD)                           Technology                                          available 
                                Square, 
                                Cambridge, MA 
                                02139 
 
Stipe             Denmark       Lyngsievvej        14.8%           N/A      N/A  Not publicly 
Therapeutics Aps                18, 8230                                            available 
(EUR)                           Abyhoj 
 
In addition, at 31 December 2019, the Group held the following investments in 
companies where it is not considered to have significant influence: 
 
Company                                                              Board     % of 
                                                                     Seat?   Issued 
                                                                              Share 
                                                                            Capital 
                                                                               Held 
 
Amplyx Pharmaceuticals, Inc.                                      Observer     3.0% 
 
Artios Pharma Limited                                                    Y    12.4% 
 
Atox Bio, Inc.                                                           Y     6.4% 
 
Aura Biosciences, Inc.                                                   Y     7.7% 
 
Autolus Therapeutics plc                                                 Y     7.5% 
 
Harpoon Therapeutics, Inc.                                               Y    10.4% 
 
Imara, Inc.                                                              Y     9.2% 
 
Iterum Therapeutics Limited                                              Y     7.3% 
 
LogicBio Therapeutics, Inc.                                              Y    13.0% 
 
OptiKira, LLC                                                            Y    13.3% 
 
Pharmaxis Limited                                                        Y    11.1% 
 
PreciThera, Inc                                                          N    13.9% 
 
VelosBio, Inc.                                                           Y     8.9% 
 
Verona Pharma plc                                                        N     2.5% 
 
The Arix Group has an interest in one structured entity, The Wales Life 
Sciences Investment Fund (registered address: Sophia House, 28 Cathedral Road, 
Cardiff, Wales, CF11 9LJ). The fund has interests in Welsh life sciences 
opportunities. A structured entity is an entity that is structured in such a 
way that voting or similar rights are not the dominant factor in deciding who 
controls the entity. The Arix Group is not deemed to have control over this 
fund for the reasons disclosed in Note 2(a). The Group's interest is recognised 
within both Investments and Receivables, and totals GBP1.7m at year-end (2018: GBP 
5.5m); the Group's exposure is limited to the carrying value within Investments 
and Receivables. 
 
12. Intangible Assets 
 
                                                                Year Ended     Year 
                                                               31 December    Ended 
                                                                      2019       31 
                                                                           December 
                                                                               2018 
 
Brought forward                                                      1,770    2,057 
 
Amortisation                                                         (287)    (287) 
 
Impairment in period                                                 (795)        - 
 
                                                                       688    1,770 
 
An intangible asset arose on Arix Bioscience plc's acquisition of Arthurian 
Life Sciences entities, relating to management fees due to Arix Capital 
Management Limited as a result of managing The Wales Life Sciences Investment 
Fund. These fees are amortised over the remaining life of the fund. The 
expected fees to be received over the remaining life of the fund have been 
reduced, resulting in an impairment to the asset in the period. 
 
13. Property, Plant and Equipment 
 
Year ended 31 December 2019 
 
                                              Fixtures    Leasehold    Office    Total 
                                                   and Improvements Equipment    GBP'000 
                                              Fittings        GBP'000     GBP'000 
                                                 GBP'000 
 
As at 1 January 2019                               258           25        30      313 
 
Exchange translation adjustments                     -            -         -        - 
 
Additions                                            -            -         6        6 
 
Depreciation charge                              (120)         (10)      (29)    (159) 
 
At 31 December 2019                                138           15         7      160 
 
Year ended 31 December 2018 
 
                                              Fixtures    Leasehold    Office    Total 
                                                   and Improvements Equipment    GBP'000 
                                              Fittings        GBP'000     GBP'000 
                                                 GBP'000 
 
As at 1 January 2018                               410           34        79      523 
 
Exchange translation adjustments                     2            1         1        4 
 
Additions                                            -            -         2        2 
 
Depreciation charge                              (154)         (10)      (52)    (216) 
 
At 31 December 2018                                258           25        30      313 
 
14. Trade and Other Receivables 
 
                                                                     As at    As at 
                                                                        31       31 
                                                                  December December 
                                                                      2019     2018 
                                                                     GBP'000    GBP'000 
 
Trade receivables                                                      771    1,734 
 
Prepayments                                                            264      359 
 
VAT receivable                                                          71       81 
 
                                                                     1,106    2,174 
 
The maximum exposure to credit risk at the reporting date is the carrying value 
of each asset class listed above. The Arix Group does not hold any collateral 
as security. 
 
15. Cash and Cash Equivalents and Cash on Long-Term Deposit 
 
                                                                       As at    As at 
                                                                 31 December       31 
                                                                        2019 December 
                                                                       GBP'000     2018 
                                                                                GBP'000 
 
Cash at bank and in hand                                              54,638   31,009 
 
Cash on long-term deposit                                                  -   60,209 
 
The carrying value of cash and cash equivalents and cash on long-term deposit 
approximates to its fair value. 
 
16. Trade and Other Payables 
 
The carrying values of trade and other payables approximates their fair value. 
 
                                                                     As at    As at 
                                                               31 December       31 
                                                                      2019 December 
                                                                     GBP'000     2018 
                                                                              GBP'000 
 
Trade payables                                                         123      228 
 
Accruals and other payables                                          6,031    3,171 
 
                                                                     6,154    3,399 
 
17. Share Capital 
 
                                                                     As at    As at 
                                                               31 December       31 
                                                                      2019 December 
                                                                     GBP'000     2018 
                                                                              GBP'000 
 
Allotted and called up 
 
135,551,850 ordinary shares of GBP0.00001 each (2018:                      1        1 
134,823,243 shares) 
 
49,671 Series C shares of GBP1 each (2018: 49,671 shares)                 50       50 
 
On 4 January 2019, the Group issued 114,358 ordinary shares, in relation to 
certain share awards. On 1 May 2019, 530,000 shares were issued, in relation to 
certain share awards. On 2 July 2019, 84,249 shares were issued, in relation to 
certain share awards. As at 31 December 2019, the Group had 135,551,850 
ordinary shares in issue (2018: 134,823,243). 
 
At the year-end date, 5,080,582 of the ordinary shares were subject to 
restrictions. These shares are not entitled to vote, attend meetings or to 
receive dividends or other distributions. Consequently, restricted shares have 
been excluded from the calculation of the weighted average number of shares in 
issue. There are no Treasury Shares in issue. 
 
18. Share Options 
 
During 2019, share-based payment expenses have been recognised relating to a 
range of share schemes operated by the Arix Group. 
 
                                                                Year Ended     Year 
                                                               31 December    Ended 
                                                                      2019       31 
                                                                     GBP'000 December 
                                                                               2018 
                                                                              GBP'000 
 
Executive Incentive Plan 2017                                          430      430 
 
Executive Incentive Plan 2018                                          883      427 
 
Executive Incentive Plan 2019                                          448        - 
 
2017 IPO Award                                                         213    1,470 
 
Executive Share Option Plan                                            567      582 
 
Founder Incentive Shares                                               179      348 
 
Non-Executive Director Awards                                           70       76 
 
                                                                     2,790    3,333 
 
Executive Incentive Plan 
 
The Arix Group operates an Executive Incentive Plan for Executive Directors and 
certain employees of the Company. 
 
In May 2017, the Executive Directors and certain employees were awarded options 
or conditional awards which, in case of options will become exercisable at nil 
cost and in the case of the conditional share awards, will vest at nil cost on 
the third anniversary of their grant, on 26 May 2020, subject to performance 
criteria. This requires the share price to have grown by a set percentage over 
the assessment period, with the quantum of shares vesting dependent on the 
level of share price growth; 1,486,747 options were unvested at year-end (2018: 
1,486,747).  In the year ended 31 December 2019, a share-based payment charge 
of GBP430k (2018: GBP430k) was recognised in relation to the Executive Incentive 
Plan. 
 
In May 2018, the Executive Directors and certain employees were awarded options 
or conditional awards which, in case of options, will become exercisable at nil 
cost and, in the case of the conditional share awards, will vest at nil cost on 
the third anniversary of their grant, on 17 May 2021, subject to performance 
criteria. This requires the share price to have grown by a set percentage over 
the assessment period, with the quantum of shares vesting dependent on the 
level of share price growth; 2,290,499 options were unvested at year-end (2018: 
2,290,499). In the year ended 31 December 2019, a share-based payment charge of 
GBP883k (2018: GBP427k) was recognised in relation to the Executive Incentive Plan. 
 
In May 2019, the Executive Directors and certain employees were awarded options 
or conditional awards which, in case of options, will become exercisable at nil 
cost and, in the case of the conditional share awards, will vest at nil cost at 
the end of the three year performance period, subject to performance criteria. 
This requires the share price to have grown by a set percentage over the 
assessment period, on 1 January 2022, with the quantum of shares vesting 
dependent on both the level of share price growth and the level of net asset 
value growth; 2,524,661 were issued in the period, all of which are unvested at 
year-end. In the year ended 31 December 2019, a share-based payment charge of GBP 
448k (2018: GBPnil) was recognised in relation to the Executive Incentive Plan. 
The charge relating to net asset value growth was calculated based upon the 
share price at grant of GBP1.5750, and the assessed liklehood of vesting. The 
charge relating to share price growth was calculated using a Monte Carlo 
simulation model, using assumptions relating to share price at grant (GBP1.5750); 
risk free interest rate (0.72%); time to vesting (3 years); and expected 
volatility based on comparable listed investments (39.6%). 
 
IPO Award 
 
In February 2017, the Executive Directors and certain employees were awarded 
one-off nil cost options or conditional awards in recognition of their 
contribution to the Company's initial public offering. The options were granted 
on 22 February 2017; all options vested after two years, on 22 February 2019. 
1,409,166 options were unvested at the start of the period; all vested, of 
which 439,799 were exercised at nil cost; 969,367 were unexercised at 
year-end.  In the year ended 31 December 2019, a share-based payment charge of 
GBP213k (2018: GBP1,470k) was recognised in relation to the IPO Awards. The charge 
was calculated as the total number of options granted, at the IPO share price 
of GBP2.07, recognised across the two-year vesting period. 
 
Executive Share Option Plan and Founder Incentive Shares 
 
At the Arix Group's inception, an Executive Share Option Plan was in operation, 
in which two Directors participated. Options were granted on 8 February 2016 
with an original exercise price of GBP1.80 per ordinary share. This was 
subsequently amended for one Director, with the exercise price reducing by GBP 
0.18 per annum for a five year period from February 2019 to February 2024. The 
number of ordinary shares subject to the options totals 5,520,559. The options 
vested in four equal proportions on 8 February of 2017, 2018, 2019 and 2020. 
The options may not be exercised after the tenth anniversary of the grant date 
and it will lapse on that date if it has not lapsed or been exercised in full 
before then. All options vest at the end of the vesting period relating to that 
option or on the occurrence of a contingent event; these include a change of 
control or cessation of employment in accordance with "good leaver" provisions. 
 
No options have been exercised to date. In the year ended 31 December 2019, a 
share-based payment charge of GBP567k (2018: GBP582k) was recognised in relation to 
the Executive Share Option Plan, calculated using the Black-Scholes model. 
Assumptions used in the model relating to the risk free interest rate and 
expected volatility were unchanged from those used in the prior period. 
 
Restricted shares with identical terms, including a GBP1.80 price for the lifting 
of restrictions, were offered to the founders of the Company, totalling 
5,080,582 shares. As these relate to a former Director, no longer employed by 
Arix, the full remaining share based payment charge of GBP179k was recognised in 
the year ended 31 December 2019 (2018: GBP348k). The charge was calculated using 
the Black-Scholes model. Assumptions used in the model relating to the risk 
free interest rate and expected volatility were unchanged from those used in 
the prior period. 
 
Non-Executive Director Awards 
 
Pursuant to their respective letters of appointment, certain Non-Executive 
Directors received a one-off share award during the year; a share based payment 
charge of GBP70k (2018: GBP76k) was recognised during the period. 
 
19. Net Cash From Operating Activities 
 
                                                                Year Ended     Year 
                                                               31 December    Ended 
                                                                      2019       31 
                                                                     GBP'000 December 
                                                                               2018 
                                                                              GBP'000 
 
(Loss)/profit before income tax                                   (75,568)   42,761 
 
Adjustments for: 
 
Change in fair value of investments                                 58,642 (51,173) 
 
Foreign exchange losses/(gains)                                      4,443  (4,583) 
 
Share-based payment charge                                           2,790    3,333 
 
Depreciation and amortisation                                          446      503 
 
Impairment of assets                                                 1,259        - 
 
Finance income                                                       (769)    (708) 
 
Changes in working capital 
 
Decrease/(increase) in trade and other receivables                   1,068    (908) 
 
Decrease in trade and other payables                               (1,553)    (243) 
 
Cash used in operations                                            (9,242) (11,018) 
 
20. Financial Commitments 
 
The Group has amounts committed to portfolio companies but not yet invested; at 
31 December 2019 these totalled GBP8.5m (2018: GBP21.0m). 
 
21. Financial Instruments 
 
Financial Assets 
 
The Arix Group has other receivables and cash that derive directly from its 
operations. Financial assets at fair value through profit or loss are measured 
as either Level 1 or Level 3 under the fair value hierarchy, as described in 
Note 2(i) and disclosed in Note 11. 
 
                                                                Year Ended     Year 
                                                               31 December    Ended 
                                                                      2019       31 
                                                                     GBP'000 December 
                                                                               2018 
                                                                              GBP'000 
 
Financial assets at fair value through profit or loss 
 
Equity investments                                                 151,921  183,981 
 
Loans and receivables 
 
Other receivables (excluding prepayments)                              771    1,734 
 
Long-term cash on deposit                                                -   60,209 
 
Cash and cash equivalents                                           54,638   31,009 
 
The credit quality of financial assets that are neither past due nor impaired 
can be assessed by reference to external credit ratings (if available) or to 
historical information about counterparty default rates. The Arix Group's cash 
and cash equivalents are deposited with A+ rated institutions. Investments and 
other receivables do not have a credit rating. However, the Group does not 
believe these to be past due nor impaired. 
 
Financial Liabilities 
 
The Arix Group's principal financial liabilities comprise trade and other 
payables. The primary purpose of these financial liabilities is to finance the 
operations. 
 
                                                                Year Ended     Year 
                                                               31 December    Ended 
                                                                      2019       31 
                                                                     GBP'000 December 
                                                                               2018 
                                                                              GBP'000 
 
Trade, other payables and accruals (excluding                        6,154    3,399 
non-financial liabilities) 
 
22. Guarantees 
 
The Company has provided a rent deposit guarantee in respect of its former US 
office, now classified as an Investment Property, for an amount of $261,657, (GBP 
198,456), unchanged from 2018. 
 
23. Related Party Transactions 
 
Consultancy fees plus expenses amounting to GBP130,262 (inclusive of VAT) (2018: 
GBP544,336) were payable to Merlin Scientific LLP during the period, a 
partnership controlled by Sir Chris Evans, a former Director and substantial 
shareholder of the Company. All contractual arrangements with Merlin Scientific 
LLP have ceased. At 31 December 2019, GBPnil (inclusive of VAT) (2018: GBPnil) was 
owed to Merlin Scientific LLP by the Company. 
 
During the period, key management has comprised Executive Directors, whose 
remuneration is disclosed in the Directors Remuneration Report; and other 
members of the Executive Committee. These other members received short-term 
employee benefits of GBP371,834 in the year, relating to the period in which they 
were fulfilling key management responsibilities (2018: GBPnil). 
 
24. Events After the Reporting Date 
 
On 22 January 2020, a further $1.9m (GBP1.5m) was invested in Iterum Therapeutics 
plc. The Arix Group's investment was in the form of convertible loan notes and 
royalty-linked senior subordinated notes. 
 
On 24 January 2020, the Arix Group participated in the Quench Bio, Inc. Series 
A financing. Arix's aggregate commitment to the company now totals over $12.5m, 
and the Group retains a stake in the company of over 20%. 
 
On 27 January 2020, Autolus Therapeutics plc closed a public offering. The Arix 
Group did not participate; its stake in the company now totals 6.5%. 
 
On 5 February 2020, the Arix Group completed the sale of its direct holding in 
Verona Pharma plc. Proceeds of GBP1.5m were received, in line with the 
investment's valuation as at 31 December 2019. 
 
On 25 February 2020, a further $2.7m (GBP2.1m) was invested in Imara, Inc., in 
line with existing commitments. The Group's fully diluted stake in the company 
now totals 9.9%. 
 
                                     ENDS 
 
 
 
END 
 

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