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Valirx Share Discussion Threads
Showing 23876 to 23896 of 23900 messages
|During clinical trials, why do researchers use a placebo for physical diseases in drug studies?
In reference to clinical trials for finding a cure or treatment. The way I see it, it makes sense to use placebo for a drug that can alleviate mental disorders. Why use placebo for drugs that are for physical diseases, such as ALS, SMA, MD, even cancer?
It's important to understand that it's not just that there's a placebo. It's also vital that the trial be double-blind, meaning that neither the doctors nor the patients know whether they're getting the drug.
There are several reasons for this. It's very easy for both doctors and patients to have some sort of bias. If a doctor has to rate the appearance of a rash, or a patient has to subjectively rate pain on a scale, they may tend to rate things better if they think a treatment is being used. A placebo provides a baseline against which to measure such biases.
Also, many conditions improve on their own. For all the illnesses you mentioned, it's not uncommon for there to be natural upswings and downswings in a patient's condition. Suppose you have 1,000 people receiving an experimental drug, and half of them show some improvement. Well, how many of them would have improved with no treatment at all? That's exactly what a placebo arm to the study tells you.
A placebo arm also helps account for the effect that people in trials get more medical attention. That is, someone in a trial is likely to do better just because they have more frequent doctor visits, more lab work, etc. They have more opportunities for the doctors to mention that they could have something to help with nausea or pain or whatever. Again, placebos allow researchers to distinguish such effects from the actual treatment being researched.
In short, without a placebo, there's just no way to know whether a treatment is effective.|
|Same here runway!!Except for paul as he top man!|
|Haha Ok John!!I'm as frustrated as you are!!|
|pat: next thing you'll be saying that santa clause doesn't exist. Watch out before you become the grinch that stole xmas.
Some of us still want to believe in a likely bumper xmas delivery from Valirx.|
|i'm filtering everyone and going to go it alone.
|When one bought stocks in 2000 based on relative cheapness most lost 90pct of their moneyBe careful with this style of investing YodaIt hasn't stood you in good stead from 50pInvest in the merits here..to me we can't rally until this overhang goesI'm a buyer at 6pI'm a believerI'm bullishBut Yoda you have been 6 years too early and continue to be too early even todayKeeping the faithPat X|
|Do you have not filtered updates I see just a complete runt Pv|
|Funny isn't is it how actual FACTS are dismissed on VALs threads/bb's as ramping.
Clearly those making such outlandish claims are from the chronic deramping camp. Yet the company continue to reap success at each stage of their scientific trials.
Still no one can advise of one single peer, anywhere in the world, that has such a low valuation with similar product potentials. Indeed there are peers with far LESS potential, that aren't as developed, with fewer ongoing trials, that are valued 10 times the MCAP here. Which in itself makes Valirx one of the most compelling investments at this level.|
|Thanks bossman will doYodaFiltered(sorry but you add nothing except a puff)|
|Lol KP9, so true. I note Patviera has now admitted to his "lies and puffing". It goes to prove his uneducated, illinformed posturing here. He hasn't brought one single fact to the forum.
John, thank you for your comments, some can't see the wood for the trees with Val. Poor marketing yes, but exceptional product development, revolutionary. I'm still waiting for anyone to show me a Prostate Cancer trial that has had the emphatic success that VAL has achieved in stage 1/2 clinical trials.
patviera23 Oct '16 - 12:57 - 3791 of 3806 0 0
No more lies and puffing
I feel rejuvenated|
|K9PFilteredWhat u say mate!!|
|Why he has options bossman?|
|pat..it does not matter because if val201 etc are successful then he's in the money its that simple..|
|How many shares does George own??!!|
|John Every CEO believes in his productCmon are you THAT naive?I hope this works but hope is all it is at the moment x|
|LantyYoda is in a mess with his investment and that's why he bullies me cos I won't just let him ramp this shareLet him buy the 20m shares that could be for sale soon..if he's so bullish let him buy themLanty I think u speak the truth|
|ALL this `new information`does it increase,decrease the share price?
I do believe investors do their own research.If not then they have only
themselves to blame for any losses.
This bb is fine if only opinions were fairly put and not RAMPED.We all
know who is doing the ramping.
Ask yourself why a certain person is giving all `information`about the
company?Do you think it is out of the goodness of his heart and bonhomie?
Or do you think it is RAMPING on his/her part?
Iknow what I think...not a lot!
|John You can't blame the institutions when many mgmnts on Aim take the P ss with their remuneration packages and funding arrangementsTell me why this mgmnt resorted to death spirals when they just don't help share price performance??!!Was a grave errorWith regards to Yoda..he is v rude and would rather have an argument for weeks about a date differenceHow comes so many like cautious money don't trust him?hes a know it all and has no idea about what makes share prices go upAgreed that he does provide some good analysis!!Take care JohnYou have respect for the individual xxx|
|Toy sure is controls g her share and the company. NOT Pev you runt|
|It's interested that the share price maintained relatively well for the years up to Dec 2014, then ironically when they started their first clinical trial the pressure turned downwards.
The most obvious explanation is from the additional funding demands that came from running the clinical trials
One might have realistically expected the share price to have surged during that clinical trial period, with the expectation of drawing ever closer to a revenue generating deal ( I certainly thought that ). But all we have seen is constant negativity related to funding matters, all whilst the trial and IP work has run pretty well gone perfectly.
Not sure there is any correlation to past presentations and funding. Apart from the Bracknor facility, but that was the very next day, so the 15 day VWAP price was unaffected.|