Synairgen Share Discussion Threads

[briannewby] 23/3/2020 15:16

Possibly due to their Sunday announcement on halting emergency supplies? Many punters think these experimental drugs can be ramped up to a global scale within a couple of weeks...

[freedosh] 23/3/2020 15:12

Hi Brian, I know it is a bit of a dinosaur company but Gilead down about 2.3% at the moment. Crazy, IMO.

[tickboo] 23/3/2020 15:02

Not sure if already posted so apologies if it has -https://www.europeanpharmaceuticalreview.com/news/115657/researchers-to-trial-sng001-therapeutic-in-covid-19-patients/

[briannewby] 23/3/2020 14:55

Freedosh - I see Remdesivir (Gilead) is one of the treatment modalities announced today in the 3200 patient European trial which also starts today. Being an open trial should get initial analysis of efficacy in a couple of weeks.

[jev1] 23/3/2020 14:37

Tidy

Spot on.

[tidy 2] 23/3/2020 14:26

Exactly. He knows it works. It sparks your natural virus defence system even if you dont have a virus that is how effective it is and how they know it works.

[pdt] 23/3/2020 14:16

Nobby - This is what I posted on 11th November and if you look at the article the research shows it was of no use in infected cells;

Interesting article published in the American Journal of Respiratory and Critical Care Medicine;

Dynamics of IFN-β Responses During Respiratory Viral Infection: Insights for Therapeutic Strategies



the abstract concludes;

"CONCLUSIONS: In vitro modelling of IFN-β dynamics highlights the potential for intermittent prophylactic doses of exogenous IFN-β to modulate viral infection. This provides important insights to aid the future design of clinical trials of IFN-β in asthma and COPD"

The authors are from University Hospital Southampton and Astrazeneca, Sweden.

And on a seperate note thanks for your work on this thread Nobby, we all appreciate it!

[asif12] 23/3/2020 14:12

when a patient inhales the stuff you would know within a couple of hours if it is having an impact - similar to getting a nebuliser dose when you are an asthmatic. So I don't see why the Gov will wait ages to see the complete results - this will be used quick and rolled out if it works

[hazl] 23/3/2020 14:09

PDT That is what I understood it protects the healthy part of the lung.
Of paramount importance so afterwards they are not totally disabled by it if they recover.

[freedosh] 23/3/2020 14:09

In addition to the indirect antiviral activity of INF-beta it also promotes anti-inflammatory cytokines that should help protect the lung and reduce immediate and late toxicity including fibrosis. The later is the reason that I am invested here. FARN will achieve the same but by a parenteral route. Anti-IL6 and IL6R MoAbs seem a little neglected but will likely have the best lung (ARDS) protective properties e.g. Chugai,Roche, Tiziana (TILS).
Best current prospect for an effective drug is from Gilead and vaccine from Moderna.
All IMO
Declaration; I hold NCYT,SGN and TILS.

[likya123] 23/3/2020 14:08

Not 2 months...when they see the positives impacts of this in trial it will have to be used immediately.

Did you noitce how confident the CEO was in the proactive video this morning?

[tidy 2] 23/3/2020 14:07

SNG001 kickstarts and boosts your bodies natural defences before you even get a virus. Inhaled as is SNG001 it is a blockbuster and complete lifesaver.

[nobbygnome] 23/3/2020 14:05

Now which over anxious punters sold out at 53p..... This is a clear hold/buy for much higher ahead of the trial results in 2 months IMHO.

[talk2dubya] 23/3/2020 14:05

People are going to be upset if you sold on that pull back, be interesting to see if we see some delayed chunky buys.

[marketanalyst1] 23/3/2020 14:05

Extraordinary opportunity and profoundly mispriced.

Buyers returning in their droves.

All available MM 'head fakes' deployed and depleted.

[pdt] 23/3/2020 14:05

It is of no use to the cells that have been infected. It is of benefit to those remaining healthy cells in the lung. They are part of the fight back process.

[nobbygnome] 23/3/2020 13:57

So to clarify it is of use once cells have been infected. The infection of cells is an ongoing process as more virus is produced in the patient so it definitely can treat an ongoing infection.

[nobbygnome] 23/3/2020 13:56

>> PDT

But it is going to be used in patients who already have been infected. That is the basis of the COPD trial and the beta interferon will boost the ongoing anti viral immune response.

[hazl] 23/3/2020 13:53

older trades coming out....

[pdt] 23/3/2020 13:46

Great video interview from Richard Marsden on Proactive today. Thanks for posting the link.

I thought it was good that he confirmed again the fact that it boosts the antiviral defences of the at risk group before they get a virus. We also know that it is of no use once the cells are infected. Therefore, there is a strong preventative argument to treat all at risk people as soon as possible.

And he reconfirmed talking to worldwide regulators once data is known as to the next steps. Some no doubt will move faster than others.

And reconfirmed the double whammy of these people having reduced immune systems and the coronvirus's ability to suppress interferon beta. Double the reason why inhaled interferon beta could be useful.

[talk2dubya] 23/3/2020 13:36

Going north again this afternoon.

[likya123] 23/3/2020 13:24

Going up from here L2 very strong..just topped up.

Expecting this to zip up with Americans now awake buying big.

Large spread trying to put buyers off, pressure buliding....
up she goes!

[1liam] 23/3/2020 13:23

Well that's certainly the kiss of death!

[hazl] 23/3/2020 13:22

....bargain territory?

[iamgreat1] 23/3/2020 13:14

Will follow same trend as ncyt soon will be 100p and more