Synairgen Share Discussion Threads

[nobbygnome] 22/3/2020 09:39

I agree. People are so sensitive if you post anything even vaguely seen as negative. As I keep on saying I actually don't see small fund raises as negative anyway. Ho hum...

[hazl] 22/3/2020 09:30

Easy to get distracted and territorial over shares and news.

The main topic here is SNG but clearly,as it involves the Coronavirus, it cannot help but reference other firms.
They don't seem to be competing to me,as they are covering a different angle,so those that knock them are misled I believe.

Let's pull together!

[likya123] 22/3/2020 08:16

3 excellent posts to follow from the lse board this morning...


Whether SYNAIRGEN do a deal or not with ASTRAZENCA, make no mistake, we are off to the races next week.
MASSIVE potential here. Easily a 5-10 bagger from here. 

Only 109m shares in issue AND combine this was the huge amount 55.8% of shares NOT IN PUBLIC HANDS, this leaves the public scrambling for just 61m shares in issue this is going to cause a big squeeze on the share price forcing it to go up VERY strongly.

Then factor in how many of the 61m shares that are already ready in the tight grip of investors who will NOT be parting with any of their shares anytime soon. Then add in the Worldwide media coverage over the coming weeks/months.

THIS IS GOING UP BIG TIME !


In so far as the Company is aware, the percentage of the Company’s issued share capital that is not in public hands is 55.8%




Another deal with ASTRAZENACA is certainly possible again considering the huge interest in SYNAIRGEN (see 18 MAR RNS below) and ASTRAZENACA (ex partner of SYNAIRGEN) saying they are "placing the highest priority to developing a treatment to coronavirus"

ASTRAZENACA: 21 MAR 20
'Our research and development team of more than 50 virology experts across research, clinical, regulatory and manufacturing are placing the highest priority to developing a treatment to coronavirus to minimise the global impact on the overall health of patients and the public.'

SYNAIRGEN: 18 MAR 20
SYNAIRGEN CONFIRM THEY ARE IN DISCUSSIONS WITH A NUMBER OF WORLD-WIDE GOVERNMENTS, MEDICAL AND SCIENTIFIC BODIES !

Synairgen to start trial of SNG001 in COVID-19 imminently

"Synairgen's other current activities with COVID-19:

Since the outbreak of COVID-19, Synairgen has been approached by, and is in discussion with, a number of other medical, scientific, and Governmental bodies (both in the UK, US and internationally) seeking to investigate novel therapeutics in this area."


Excellent article today in "thisismoney" about both AstraZenaca and Synairgen.

I know this article says AstraZenaca to do research deals this week involving monoclonal antibodies, which is NOT Synairgen. HOWEVER, the article goes on to say "Synairgen – which was previously a partner of AstraZeneca"......so could AstraZenaca team up with Synairgen again?

Even if not, this is an excellent article promoting Synairgen's trial,one of the 10'S,if not 100's, of articles about the Synairgen trial over the coming weeks/months. (By the way, its a 14 day trial initially, not two months as the article says though it will be expanded).

21 MAR 20
Drugs giant AstraZeneca in talks with governments to find cure for virus


ASTRAZENACA:

Research agreements could be announced in the coming days.A deal would see the company team up with experts on monoclonal antibodies 

SYNAIRGEN:

Other companies are also ramping up their efforts to help battle the global outbreak. A smaller British firm called Synairgen – which was previously a partner of AstraZeneca – is this week starting human trials to test if its existing lung treatment will help patients who have contracted Covid-19. If the results come back positive, the company hopes to be able to start treating patients within the next year.

The pilot phase, beginning this week, will last two months and will involve 100 patients – half of which will be given placebos while the remainder take the potential treatment. If the results are positive, the company will begin a larger human 'pivotal' trial.

Richard Marsden, chief executive of the AIM-listed company, said he is convinced that getting a treatment ready for widespread use within a year is 'feasible'. In normal circumstances these trials take several years to complete.

'There might be two or three drugs which produce positive data over the next eight weeks,' Marsden told The Mail on Sunday. 'If we get good data and it's well tolerated, I would expect governments to be under pressure to want to talk to us about larger supplies of the drug.' 

Marsden hailed the authorities for giving his company fast-track approval for its test medication which it is also hoping will treat asthma and the lung condition known as COPD

[talk2dubya] 22/3/2020 08:13

If they did place (government funding would seem likely as well) then I would imagaine it would be to existing IIs at a discount or to new institutions at a premium. I could see a major take a stake here, it’s pocket change.

Interesting Daily Mail article, thanks fo sharing.

[nobbygnome] 22/3/2020 08:12

Yes 100k of my 105k shares will be going absolutely nowhere.....

[likya123] 22/3/2020 08:07

Daily Mail!! This is going bananas tomorrow!

[pdt] 22/3/2020 07:56

As pointed out on another thread we have got to the stage of a mention in the Daily Mail;



'There might be two or three drugs which produce positive data over the next eight weeks,' Marsden told The Mail on Sunday. 'If we get good data and it's well tolerated, I would expect governments to be under pressure to want to talk to us about larger supplies of the drug.'

So supplying governments worldwide with large supplies could be an issue. The Astrazeneca link is again mentioned.

[nobbygnome] 22/3/2020 07:17

So I expect this may not be a popular post but I think must be taken into account. There is a good chance that at some point this week, there will be a small fund raising to bring in say £4-5 million which at this level would not be very dilutive. For me it makes perfect sense and is absolutely nothing to worry about. I guess it won't be done at much of a discount and certainly shouldn't be a signal to dump all your shares. There is the possibility that they are looking at some sort of deal with a Pharma to bring in some money upfront which would negate the need for a fund raising but I think the latter is more likely.

Anyway nothing to worry about and I am sure with the high volumes which are going to continue, the price would take any raise in its stride. Of course all IMHO and DYOR....

[grafter] 21/3/2020 23:07

Inhaled interferon-beta launches into the fight against the Covid-19 pandemic

Synairgen plc, a respiratory drug discovery and development company, announced it received approvals from the Medicines and Healthcare products Regulatory Agency (MHRA) and Health Research Authority (HRA) to conduct a trial of SNG001 (inhaled interferon-beta-1a) in Covid-19 patients.

A pilot phase of the study will take place across a number of National Health Service (NHS) trusts, initially testing 100 Covid-19–positive patients. Following successful completion of this pilot phase, a Phase II double-blind, placebo-controlled trial would start imminently to assist with the global outbreak of the virus.

Angad Lotay MPharm, Infectious Diseases Analyst at GlobalData, a leading data and analytics company, provides his view:

Synairgen previously tested SNG001 in patients with chronic obstructive pulmonary disease (COPD) with the common cold or influenza. Lacking an effective anti-viral treatment, those with COPD exacerbations account for the second most likely group of patients to be hospitalized in England. This targets a considerable unmet need and although the trial has currently been paused (to minimize the chance of vulnerable patients being exposed to further infection risk), initial data showed marked changes in COPD symptoms in patients with a confirmed common cold or influenza. Clinical trials in asthma have also shown that treatment with inhaled SNG001 reduced lung viral load and lung pathology in an in vivo swine flu–driven model of viral pneumonia. At the time of the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in 2013, Synairgen collaborated with the National Institutes of Health (NIH) in the US to show that SNG001 could protect against MERS-CoV infection of lung cells in vitro.

Furthermore, viruses, such as severe acute respiratory syndrome (SARS-CoV-2) and MERS-CoV, have evolved mechanisms that suppress endogenous IFN-beta production, thereby helping the virus evade the innate immune response. Research conducted in Hong Kong revealed that patients who recovered from the coronavirus had sustained lung damage, and therefore it is possible that patients may not fully recover their lung function following the infection. Synairgen’s SNG001, a formulation of IFN-beta-1a for direct delivery to the lungs via nebulization, will, therefore, prevent cell damage in a similar fashion to that of MS patients.

DYR -

[yet another final] 21/3/2020 22:49

Allstar , the trend in share price will be upwards, but no doubt resemble somebody's ECG (heart tracing) whilst on a treadmill.You must have the discipline to choose when to buy, when to top up and to sell (ala chess - ur moves are already provisionally mapped out) and advice from an old git.... Don't fall in love with a share

[allstar4eva] 21/3/2020 22:39

Thanks - I thought the same about a quid. Obviously you never know as there is a lot of publicity around this right now.

[yet another final] 21/3/2020 22:34

Freedosh, ur comments on the science and disease process have always been informative and you have pointed other useful shares in these testing times.

[nobbygnome] 21/3/2020 22:33

>> dave

Yes probably more hopeful than the reality. As long as I can get 1000...

I may well buy some by spreadbet too although annoyingly Spreadex had them as phone only trade most of Friday!

[freedosh] 21/3/2020 22:24

What on Earth do you gain by knocking ncyt yeti?
I choose to post what I hope is informative comments on companies with diagnostics, therapeutics and vaccines. I don’t have the time to post everywhere so just use the ncyt board.
We are all in this together.
Like bounty and hazl I am also substantially invested here. I am also invested in in TILS that has a MoAb aiming like SNG to reduce the potentially lethal lung toxicity of Covid-19.
Role back through my posts to see my thoughts on, for example, Gilead and Moderna.
The enemy is Covid-19, not ncyt investors.

[yet another final] 21/3/2020 22:23

Can I call u Leonard (bbt)

[yet another final] 21/3/2020 22:22

Btw I value any posters input which provides snippets of useful information.I have yet to read any valuable post from bounty in the past few months. In fact his post on this thread was purely to promote another share, and add no value to the readers.My apologies, I rant, but any newcomer to this thread would be distracted by irrelevant name dropping (told u this would happen. Final words said!

[davew28] 21/3/2020 22:21

Thanks Nobby. Think you're 50p opening gambit on Monday is a bit optimistic (for your moneybox money) though agreed £1 is probably overly optimistic for now. However the amount now riding on this is huge given the deaths and the money being thrown now to rescue virtually all economies, businesses, jobs, livelihoods, homes and so many lives.

[lukead] 21/3/2020 22:19

Thanks for the protocol posting,

[nobbygnome] 21/3/2020 22:17

As I have said before, I have no problem with reasoned negative views. However, trolling or endless repetition of the same negative view will not be tolerated!

Oh the power...

[yet another final] 21/3/2020 22:15

Thank you NobbyI have been openly critical of NCYT for several reasons (btw I owned it and sold three times making a good profit) Unfortunately Bounty has the cheek to come on here asking for me to be filtered/moderated, for pointing out deficiencies in NCYT, which he elects to dismiss rather engage in reasonable debate. Guess he must be a dictator, and how dare I speak up against the regime I am invested here and will continue to be until the 'story' changes, and the reserve the right to be critical of the company when appropriate

[nobbygnome] 21/3/2020 22:11

>> Eva

My guess is around £100 million (95p ish) before the trial result so about a doubling from where we are now. But of course it is really just a guess...

[nobbygnome] 21/3/2020 21:59

>> Dave

My understanding is that it is an off the shelf inhaler. Having enough supply of drug is an issue assuming the trial is positive and I would be interested to know if they are manufacturing drug at risk. Of course it will be contracted out to a third party so is not actually done by SNG.

[bountyhunter] 21/3/2020 21:58

Fair enough, but keep an eye on him :)
He is one of only a few I have had to filter on my NCYT Covid-19 thread.