Summit Therapeutics Share Discussion Threads

[hugus maximus] 07/10/2016 15:10

And suddenly some interest moves the share price back up to 208p?

[patviera] 07/10/2016 14:56

My levels and charts are good(supposedly)Hope you all managed to buy sub 200pOnwards and upwards

[solomon] 07/10/2016 14:24

The company does have a bit of history to overcome with its shareprice.
Neo, I don't think WE are missing anything. It's THEM.

Anyway, are we seeing a little bit of short-covering today at the 194 - 195 area?

[neo26] 07/10/2016 14:02

hasnt this company just signed license agreement with upfront payments of $40m(£33m)?

Yet mkt cap 117m, what are we missing?

[chrisatrdg] 07/10/2016 12:46

Summit Therapeutics plc : Exercise of Options RNS

[waterloo01] 07/10/2016 12:07

Hyper, yes but only if you understand the importance of Utrophin uptake along whole fibre and into hard to reach heart and lung muscle.

[hugus maximus] 07/10/2016 11:53

Thanks Waterloo - it's really good to see this important data again and for anyone who hasn't looked at the fundamentals - this is high octane stuff!

[waterloo01] 07/10/2016 11:30

The paper highlighted by Hyper Al yesterday, while not new is a very important paper as it provides evidence in Mice that of utrophin uptake along the whole fibre. Key to efficiency.

"After 5 weeks of daily oral treatment with SMT022357, utrophin is localized along the entire length of the sarcolemma. This first documented evidence of utrophin homogeneously localized along the length of 7-week-old mdx muscle fibres demonstrates that SMT022357 is capable of inducing and/or maintaining utrophin transcription from extrasynaptic myonuclei."

"Importantly, our results demonstrate that the oral delivery of SMT022357 distributes drug not only to skeletal muscle, but also to the diaphragm and the heart"

I think that's the first published evidence of that and when understood is very good news!

[patviera] 07/10/2016 10:24

There are costs involved with arbing with the adr and will depend on whether they for turning or not

[luminoso] 07/10/2016 10:13

Not a clue ! I'd like to think they are holding it down before a stonking rns at 12 noon, but that is a bit delusional !
Maybe the MMs only look at the $/£ exchange rate on a weekly basis !!
Perhaps its moving too fast for them.

[hugus maximus] 07/10/2016 10:09

Strange - how can that be so luminoso?

Edit: Agreed $ 13.37 closing price makes share price here start @ £2.15

[luminoso] 07/10/2016 09:02

Still a dollar difference between Nasdaq and AIM.

[patviera] 07/10/2016 06:39

Lower pound is good for summit

[waterloo01] 07/10/2016 00:15

Hyper, there is some important detail in that paper.

[luminoso] 06/10/2016 21:03

AIM closing price is about $12.30. Falling pound changing the game daily. So with the Nasdaq at 13.30 currently, we might be looking at an up day tomorrow on AIM ?
Meanwhile, any theories about the big trades reported after hours on AIM ? 350,000 shares traded at £2.50 plus in four batches.

[neo26] 06/10/2016 20:38

PatvieraI'm interested in this stock, don't flatter yourself.I've already made some money yesterday as a quick punt.Trying to do some research for longer term.

[chrisatrdg] 06/10/2016 19:28

Detailed below is my earlier posting of Wednesdays/Thursdays posters - items in BOLD have been issued i.e. x3 but P146 has not been & I guess is yet to be posted not sure if this is significant - I guess not.

See Edit Note below - looks like 4th item in press release but no poster issued.

21ST INTERNATIONAL WORLD MUSCLE SOCIETY CONGRESS
4-8 October 2016, Grenada, Spain

Further details on Summit posters and link below:

Wednesday 5 October 2016

16:00–17:30
Program/Neuromuscular Disorders 26 (2016) S55–S86 S63 Poster presentations 2: parallel sessions (P.100–215) – Poster area

ISSUED

P.144 UTROPHIN MODULATORS SIGNIFICANTLY IMPROVE THE MUSCULAR DYSTROPHY IN THE MDX DIAPHRAGM
S. Guiraud; H. Chen; T. Kennedy; S. Squire; B. Edwards; D. Burns; N. Shah; A. Babbs; S. Davies; G. Wynne; A. Russell; D. Elsey; F. Wilson; J. Tinsley; K. Davies

ISSUED

P.145 SECOND GENERATION UTROPHIN MODULATOR FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
S. Guiraud; S. Squire; B. Edwards; H. Chen; D. Burns; N. Shah; A. Babbs; S. Davies; G. Wynne; A. Russell; D. Elsey; F. Wilson; S. Harriman; J. Tinsley; K. Davies

NOT YET ISSUED (Mentioned in press release but no poster shown - See Edit note below)

P.146 Utrophin modulation for the treatment of cardiomyopathy in mdx mice
D. Burns; S. Guiraud; C. Carr; S. Squire; B. Edwards; H. Chen; T. Kennedy; A. Babbs; N. Shah; A. Berg; G. Wynne; A. Russell; D. Elsey; S. Harriman; F. Wilson; J. Tinsley; K. Davies




Thursday 6 October 2016

Poster presentations 3: parallel sessions (P.216–308) – Poster area
DMD treatment approaches I; (P.216–230) Chairpersons: Kay Davies and Eugenio Mercuri

15.00–16:30

ISSUED

P.223 DEVELOPMENT OF DIGITAL TISSUE IMAGE ANALYSIS SOLUTION FOR MUSCLE BIOPSIES IN SUPPORT OF DISEASE-MODIFYING THERAPIES FOR DUCHENNE MUSCULAR DYSTROPHY
J. Tinsley; C. Pulliam; A. Milici; F. Aeffner; K. Davies; S. Moore

Edit:Additional presentations at WMS 2016 reported preclinical data highlighting the potential of utrophin modulation as a disease-modifying treatment for all patients with DMD, regardless of the underlying fault in the dystrophin gene. This research was conducted at the University of Oxford under the UtroDMD alliance.

[patviera] 06/10/2016 18:56

What are they over there luminoso?

[patviera] 06/10/2016 18:55

FootballFirstly I wrote yday so that's rubbish that I only post on the blueSecondly I'm long so not sure what you are insinuating footballThirdly I wrote that I would be a buyer sub 2poundsSo football bore off and start on some one else

[ohsod1t] 06/10/2016 18:38

Has always been so......