Scancell Share Discussion Threads

[gooosed] 19/9/2017 11:51

"Vaccines

Anti-PD-1 monotherapy may be limited by the size of the pool and specificity of pre-existent tumor directed T cells generated by physiological interaction of the evolving tumor and the host immune system. Particularly for tumors with low mutational burden, it is conceivable that insufficient numbers of T cell clones are spontaneously primed by tumor antigens, and therefore, a critical threshold of T cells is not reached to trigger an immune infiltrate. An effective vaccine may provide the necessary stimulation to broaden the repertoire of T cells engaged in the anti-tumor response. The accumulating evidence for tumor neoantigens as critical target antigens for tumor rejection coupled with the striking correlation of anti-CTLA-4 and anti-PD-1 induced tumor responses with the mutational/neoantigen load in NSCLC, melanoma, and microsatellite instability (MSI) high tumors make a strong case for vaccination targeting neoantigens [7, 8, 9, 13, 14]. The most effective vaccination strategies will aim to co-administer neoantigens, or other potential antigens that can be targets for T cell recognition (e.g., tissue differentiation or cancer stem cell associated antigens), with strong immune-adjuvants such as TLR agonists, possibly taking advantage of new delivery systems such as novel material engineered scaffolds."



"with strong immune-adjuvants such as TLR agonists" - as alluded to in Final Report with ref to Modi-1.

[wanderer1210_0] 19/9/2017 10:55

P7 You're banging your head against a brick wall. There where many here who said what would happen to the share price years ago, only to be laughed at and made fun of. The problem of funding is a huge one here, it can only lead to a massive dilution of equity imo, can't see this one working out for long term holders. The only Tick Tock now is the clock running down on finance. I'm still in the belief that if Scancell had a product worthy of anything the big boys would of snaffled it up by now. Looks like a bottomless money pit to me with no revenue and no trials, a huge mess imo

[montyhedge] 19/9/2017 10:31

Will they need another placing or have they got cash to survive until hopefully this gets approval in a couple of years time?

[gooosed] 19/9/2017 10:30

panama7 - RG has held his hands up and admitted that they made a mistake by not going to the US sooner than they did (BioCap Conference) but he cannot single handedly alter the sentiment surrounding vaccines throughout an entire Industry. He can and has knocked on doors and kept the Science, particularly Moditope, advancing with LD's tweaking (adjuvant linker technology) etc.

So to the contrary you don't appear to be taking any of it into account but hey - have it your way :

"intransigent /ɪnˈtransɪdʒ(ə)nt/

synonyms: uncompromising, inflexible, unbending, unyielding, unshakeable, unwavering, resolute, unpersuadable, unmalleable, unaccommodating, uncooperative, stubborn, obstinate, obdurate, pig-headed, bull-headed, single-minded, iron-willed, hard-line, hard and fast, diehard, immovable, unrelenting, inexorable, inveterate, rigid, tough, firm, determined, adamant, tenacious; More
informalstiff-necked;

informalbloody-minded; informalbalky, badass; rareindurate

"his intransigent attitude led to the quarrels with his friends"

You've shared some good research in the past - I hope you afford yourself the chance of asking RG at the AGM for a full and frank explanation surrounding the place vaccines has had within the Oncology sector over the last few years - as clearly you choose to ignore everything & everyone else.

[panama7] 19/9/2017 10:07

Goosed, so taking all that into account the best Goodfellow can do is raise funds at their lowest value for 5 years a 60% discount to the raising at 22p, to do the trial in the first place. I can only assume the IP lost 50% of it's value in those 4 years.

[gooosed] 19/9/2017 09:52

panama7 - More than happy to agree re your right to free speech.

However, the recent wholesale media commentary & evidence (from numerous sources) supports Goodfellows comments re the return of sentiment surrounding vaccines. Particularly when voiced by Oncology MD's, researchers and industry bodies.

All serves to highlight your comments as being intransigent (at best) and bordering on the obsessive.

[panama7] 19/9/2017 09:12

Goosed, we have every right to lambast Goodfellow, he has just raised funds at the lowest share price for 5 years at a time when vaccines are in vogue. He has spent the last 5 years decimating the share price left virtually every LTH sitting on losses and failed to deliver on all his statements and rhetoric. He has openly encouraged and coerced Chelsea into continually buying the share stating that everything is on track and going to plan when nothing could be further from the truth. We now have the SCIB1 vaccine sitting on the shelf doing nothing eating into it's use by date because the trials are running significantly late. He is simply out of his depth and is quite frankly his contempt and lack of respect for share holders points him out as a very nasty little man.

[gooosed] 18/9/2017 21:55

chelsea35 - yes and a reminder perhaps to those that continually lambast Richard Goodfellow :

“We couldn’t get any big pharmaceutical company to even talk to us about a cancer vaccine” while he was at the institute, Heery said, but now partnerships and deals involving vaccine-making biotechs are common.

“I don’t think that’s a coincidence,” he said. “I think they’re reading the tea leaves.”

Not sure about "common" but with the Moditope Patent - who knows ;-)

[chelsea35] 18/9/2017 20:08

Good to hear so soon after Bavarian Nordic.

[the real lozan] 18/9/2017 19:07

"May being a month = can be a month .."
May be, but it also 'CAN' fly.!!!

[chelsea35] 18/9/2017 18:04

Agree with that Lozan, not doubting we will get it at all, just the timelines. Odd day today, the bid fell from 12.8 to 12.725, and the ask 13.24 to 12.895 in one tick down.
Must be a hefty sell to come, but MMs still wanting shares? Not so easy to read on a volume of 248!!!

[the real lozan] 18/9/2017 15:46

One could say = "The RISKS here are 'PATENTLY' clear"

[inanaco] 18/9/2017 15:44

May being a month = can be a month ...

[tosh123] 18/9/2017 15:38

????????????????????????? No point debating "may" ... as that can also mean "can"

Surely you mean " no point debating "may" ... as that may also mean " can ".

[tosh123] 18/9/2017 15:35

I don't need to debate the meaning of " can ", the Oxford dictionary already does that most eloquently.

[inanaco] 18/9/2017 15:15

so Tosh and Herbie are One .... LOL

[inanaco] 18/9/2017 15:14

Gazza

No point debating "may" ... as that can also mean "can" .. according to Tosh

so that's best left with Tosh to explain

I see it as may be allowable once the Patent is fully processed as this is not the area of dispute.

[tosh123] 18/9/2017 15:10

Wanderer... that made me laugh out loud... great post.
Sums up in a couple of lines, just how idiotic a certain persons posts are.

[tosh123] 18/9/2017 15:09

Gazza, once again, you are 100% correct, and therefore by definition, the risks are " investment risks " NOT personal risks.
The village idiot has ONCE AGAIN, painted himself into a corner and destroyed his own flawed argument, its like taking candy from a baby. Still, at least he clearly now accepts that his statement is totally misleading and WRONG.

[wanderer1210_0] 18/9/2017 15:07

I wonder where Legal and General have filed these sharesHigh RiskModerate RiskLow Risk or of courseNo RiskI know where my tenner lies lol

[inanaco] 18/9/2017 15:01

Gazza, Its already priced in ... the share knows about the patent today ... its been in an RNS ..

[bermudashorts] 18/9/2017 14:59

Drdobson and Tosh - are you related? Your posting style is very similar.