Some AIM companies have done OK; AMS IS ONE. HONEST MANAGEMENT STAYED HONEST. Others start honest but end up needing to fiddle to survive, so they bend it Yet others come to AIM to milk easy money , reducing the project risk till ripe to be bought in.
Rocket Fuel may be too close to the truth for comfort. He remembers the tricks played on investors including HMER ; (If they are not wasting the trial money and results are not negative you would expect the value to keep in step plus . This is now a huge upside bet for the funds. I got out at 6.5 years ago because I could smell the stench. I hope I am wrong because it would be great to reduce stroke sufferers misery and that of their folk and to do so honestly|
|You do wonder alimo .....you do wonder?|
|Rigged? I lost out big time on Renovo when the IP was lauded by many in the bio world and Phase 1&2 trials appeared to meet acceptable endpoints. Phase III trials did and then didn't(most confusing) and everything that was so promising and the glowing lost pipeline just disappeared mysteriously and wasn't worth buttons, after the tens of millions spent on development, and nobody was sent to jail! So what is being rigged, here, and for what purpose.
We have been told and have watched the video results of one of the people who has greatly improved mobility during the trials. Huge amounts of money have been invested. Are you saying that original investors who have not averaged down as the huge dilution has occurred, will never see a return on their investment? Or are you saying that the share price is being manipulated to help the wealthy get wealthier. OR will it be the big sickener, that just as all the research proves successful, and the future should be rosy (even for the original investors), the company is taken/bought out, and PIs denied any opportunity to increase their wealth. If AIM is such a fiddle, why is the small investor encouraged by brokers to invest, and why don't the company regulators do more to protect small shareholders from ruthless greed of the very wealthy?|
|more drops - guess im writing off my money in this one - and yet i totally believe in the products and processes....
It is sad that companies seek to go Public when they are not suited ; AIM has been a disaster barring less than a handful of situations.I hope you will not lose your money but it is beginning to look solidly rigged|
RENE presenting on Monday|
|more drops - guess im writing off my money in this one - and yet i totally believe in the products and processes....|
|Merry Christmas all and a happy, healthy and prosperous new year.
Whilst healthy is the most important, it would be nice to get an injection of proaperity.
Guess time will tell.
Good luck all.
|as over 50% of the stop is owned by 3 fund managers legally committed to ensuring this doesn't happen unless friendly and fair
Exactly; Its easily a done deal, perhaps with a small premium|
|Its a bit like doubting Thomas. Looks like market needs to be 100% certain, as currently no appetite for risk.Hopefully Renes 2017 results will calm fears. Time will tell|
|Rene cannot be taken out on the cheap, as over 50% of the stop is owned by 3 fund managers legally committed to ensuring this doesn't happen unless friendly and fair!|
|The share price is worrying for 2 reasons
1. Could it be that Rene is being prepared for a cheap takeout?
2. Could it be that progress is not rated by those in the know?|
|Cheers. The more patient stories the better.|
|Excellent patient driven article. Very positive and c/o flier lse site
I suspect the placebo will be done in the way it has for the trial of another neuro surgical procedure i.e. the placebo patients will be prepared for the surgical procedure and then have a small incision so that they are unaware that they haven't had the full procedure.
It is amazing how often there is a real placebo affect.
Having said that I have first hand experience of a close relative who has suffered a major stroke six months ago and would say that a 75% chance of some clinical improvement seems to be well worth trying given the only treatment option is physiotherapy with diminishing returns as time goes on.|
|Having this kind of brain op is really no big deal these days. It's not as if they, as in some procedures, saw the top of your skull off and expose the entire cerebral hemispheres, lift them up and play with the bits underneath. No, a small hole is drilled through the skull and a very fine needle delivers the stem cells. If you have lost the use of your hands and arms, I suspect that taking part in a randomised trial where you have a 50% chance of receiving the treatment (which so far has seen excellent results, so you have 50% x 75% = 37.5% overall chance of seeing significant benefits after 12 months) is the least of your worries. And it's actually better than this because, if the trial goes well, it is possible that it could be stopped early and, if you were one of the placebo groups, you would probably be transferred immediately over to the therapeutic. And, remember, just taking a pill in a trial can be very dangerous:
|Norbus, true. it's not like taking a pill, however there is also very little alternative for stroke patients. On placebo, I've no idea how this might be done in this treatment and one wonders if they can't use either a control group of similar size or natural history?
However they will need some sort of placebo as they will need to prove that the improvements seen are above the normal recovery curve.
I guess I'm starting to understand the market reaction as I also hoped to see clearer transformative progression, although the 75% seeing clinical benefit is - on the surface - rather good.|
Messing inside brains is dangerous and expensive; The pull to go for treatment needs to be really convincing for there to be a serious market against alternate choice|
|Some interviews with one of the 4 might also help bring it into focus.|
|Waterloo01 - good points I agree. You've literally laid out all the points I had in mind. I do find it strange when companies fail to promote their good news in the most effective positive fashion. What do they employ brokers and PR companies for for heavens sake!! What a waste of money PR is in my investing experience. Clueless.
And yes there is a seller out there and they have largely caused the brakes to be slammed on the share price IMO. The great unknown is how much more stock they want to shift. If it's not too big then we might find the share price starting to elevate in the next few days or weeks. Perfectly possible as the news IS positive and the company has stacks of cash. A new II coming on board would help of course.|
I guess it's the missed endpoint (because endpoint was after 3 months and they met it after the deadline) that has caused the initial reaction, but 4 of 21 patients (20%) made significant improvement in the main score.
If the end point had been longer, the headline would have been different, in patients who normally don't show much recovery.
I'd definitely have led with ...."In all, 15 out of 21 patients had a clinically significant response on at least one efficacy measure, with these improvements kept up throughout the follow-up period".
That's 75% did show a 'clinically significant response" and that's impressive.|