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REDX Redx Pharma Plc

12.00
-0.75 (-5.88%)
19 Apr 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Redx Pharma Plc LSE:REDX London Ordinary Share GB00BSNB6S51 ORD 1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  -0.75 -5.88% 12.00 11.50 12.00 12.75 11.75 12.75 342,013 16:35:05
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Pharmaceutical Preparations 4.2M -33.16M -0.0852 -1.38 45.71M

Redx Pharma plc Interim results for six months ended 31 March 2017 (3516F)

17/05/2017 7:00am

UK Regulatory


Redx Pharma (LSE:REDX)
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TIDMREDX

RNS Number : 3516F

Redx Pharma plc

17 May 2017

17 May 2017

AIM: REDX

REDX PHARMA PLC

("Redx" or "the Company")

Interim results for the six months ended 31 March 2017

   --      Clinical trial application filed for Porcupine inhibitor RXC004 

-- Development candidate chosen for reversible BTK inhibitor RXC005 for drug resistant chronic lymphocytic leukaemia

   --      Strategic restructuring completed post period; estimated GBP4.2 million annual cost saving 
   --      Iain Ross appointed as Non-Executive Chairman of the Board from 1 May 2017 

-- GBP12 million gross raised in March 2017, including a subscription with a related sharing agreement

Pipeline highlights:

   --      RXC004 - our "best-in-class" Porcupine inhibitor 

o Clinical trial application (CTA) filed post period in April

o Scheduled to enter first-in-human studies upon CTA approval

o Shown to have the potential to be used in combination with immune checkpoint inhibitors (anti-PD-1)

   --      RXC005 - our "best-in-class" reversible BTK inhibitor 

o In vivo proof of concept achieved for the reversible BTK program

o Development candidate nominated for drug resistant chronic lymphocytic leukaemia (CLL)

o Pre-clinical profile presented at ASH meeting in December 2016 and iwCLL in May 2017

o Investigational new drug (IND) application and CTA to be filed around the end of 2017

Other highlights

   --      Fibrotic disease selected as core immunology research area 

-- Redx acquired the locally acting Rho kinase (ROCK) inhibitor AMA0825 from Amakem NV in March 2017 for an undisclosed amount. ROCK is a promising anti-fibrotic target and AMA0825 is at late lead optimisation stage

-- Redx was awarded US$1 million competitive grant by CARB-X to enable the Company to advance its Gram-negative anti-infective program with a prospective partner

Dr. Neil Murray, Chief Executive Officer of Redx Pharma, commented, "Redx Pharma is now optimally positioned to capitalise on the potential of its world class discovery engine with the transition to clinical development of our two best-in-class assets RXC004 and RXC005 in oncology. I am also excited by the potential of our pipeline in fibrosis, bringing novel medicines to areas of severe unmet need. We look forward to announcing the start of our first clinical trial with RXC004 and to building greater value for our shareholders as a clinical stage business."

Iain Ross, Chairman of Redx Pharma, added, "I have been impressed by the potential of Redx Pharma's science, approach to drug discovery and the speed with which the Company has created a world class pipeline of best-in-class products. Following the recent re-structuring of the organisation we are now focused on implementing an aggressive strategy to accelerate the "realisation of value" by progressing the clinical and commercial development of our lead programs and maximising the long term potential of the pipeline. I am delighted to be working with the Redx team."

Key Financials

   --      Net cash at 31 March 2017: GBP5.1m (2016: GBP4.4m) 
   --      Comprehensive loss: GBP10.7m (2016: GBP7.1m) 
   --      Strategic refocus expected to deliver annual cost savings of GBP4.2 million 

Presentation and Conference Call

Redx Pharma will host a presentation and conference call for analysts and investors at 12:30pm BST / 7:30am EDT today at the offices of Consilium Strategic Communications, 41 Lothbury, London, EC2R 7HG, UK. A presentation will be available on the Redx Pharma website 10 minutes before the start of the call at http://redxpharma.com/investors.html. To access the conference call, please dial one of the appropriate numbers below quoting the conference ID.

   United Kingdom:                  +44 (0) 1452 555 566 
   United States:                       +18 669 669 439 
   Conference ID:                      21560455 

The call will be conducted in English and a replay will be available on the Company website for 30 days.

For further information, please contact:

 
 Redx Pharma Plc 
------------------------------------  ----------------- 
 Neil Murray, Chief Executive          +44 1625 469 900 
------------------------------------  ----------------- 
 Karl Hård, Head of 
  IR & Corporate Communications        +44 7491 651 406 
------------------------------------  ----------------- 
 
 Cantor Fitzgerald Europe 
  (Nomad & Broker)                     +44 207 894 7000 
------------------------------------  ----------------- 
 Phil Davies/ Michael Reynolds 
------------------------------------  ----------------- 
 
 WG Partners (Joint Broker)            +44 203 705 9317 
------------------------------------  ----------------- 
 Claes Spång/ Chris 
  Lee/ David Wilson 
------------------------------------  ----------------- 
 
 Consilium Strategic Communications    +44 203 709 5701 
------------------------------------  ----------------- 
 Amber Fennell/ Matthew 
  Neal/ Melissa Gardiner 
------------------------------------  ----------------- 
 redx@consilium-comms.com 
------------------------------------  ----------------- 
 

About Redx Pharma Plc

Company website: Redxpharma.com

Redx is focused on the discovery and development of proprietary, small molecule therapeutics to address areas of high, unmet medical need, principally in cancer, immunology and infection providing a pipeline of assets to larger and emerging companies. By improving the characteristics of existing drug classes to create highly differentiated, novel, best-in-class drugs, Redx has already established a broad portfolio of proprietary drug programs.

CHAIRMAN'S AND CHIEF EXECUTIVE'S STATEMENT

INTRODUCTION

We are pleased to report on the progress Redx has made in the six months ended 31 March 2017.

The Company has continued to make excellent across its proprietary research programs and we remain very encouraged with the potential of the drug assets we are developing. As we have previously indicated, we intend to commercialise these assets through partnerships, out-licensing or co-development at the pre-clinical stage or in early clinical phases.

In October we announced that we have identified a drug development candidate for our reversible Bruton's tyrosine kinase (BTK) inhibitor program. The compound, named RXC005, has the potential to treat the majority of patients suffering from chronic lymphocytic leukaemia (CLL), including those who become resistant to the increasingly used treatment ibrutinib (IMBRUVICA(R)). RXC005 is equally potent against the most common type of BTK protein implicated in CLL and the mutant C481S BTK protein, which is resistant to ibrutinib.

The Company's first clinical trial application (CTA) was filed for our Porcupine inhibitor, RXC004, in April 2017.

In March 2017, we successfully completed a share placing and subscription to raise GBP12 million gross.

Lanstead Capital L.P. agreed to subscribe for 11,500,000 subscription shares at 37.5 pence representing gross proceeds of GBP4,312,500. GBP646,875 of the subscription proceeds (being 15 per cent. of the gross proceeds of the subscription) was retained by the Company and GBP3,665,625 (being 85 per cent. of the gross proceeds of the subscription) was pledged to Lanstead under a sharing agreement pursuant to which Lanstead will make monthly settlements (subject to adjustment upwards or downwards, as measured against a benchmark price of 50 pence per ordinary share) to the Company over 18 months. As a result of entering into the sharing agreement the aggregate amount received by the Company under the subscription and the related sharing agreement may be more or less than GBP4,312,500.

These new funds mean that Redx can continue to progress its promising pipeline.

We also announced in March a strategic refocus and restructuring of the Company. This restructuring has (post period) been completed according to plan and will result in an estimated GBP4.2 million annual saving in fixed costs. Redx is refocusing its business to concentrate on its key assets in oncology and immunology. The Company remains committed to discovery research, but at a reduced level. Anti-infective research will continue only under external collaborations and, to this end, we announced the receipt of a US$1 million grant from CARB-X to support our NBTI program.

PIPELINE DEVELOPMENT

Overview

Redx's research focus remains on scientifically well-validated targets which are commercially attractive, differentiable, fit Redx capability and have limited competition. Going forward the focus will be on oncology and immunology, with particular emphasis on immuno-oncology, direct tumour targeting and fibrosis. Infectious disease targets will only continue under external collaboration.

Our most advanced assets are in oncology, namely the Porcupine inhibitor RXC004 for pancreatic, gastric and biliary cancer and the BTK inhibitor RXC005 for chronic lymphocytic leukaemia. We filed a clinical trial application (CTA) for RXC004 in April and we plan to start first-in-human studies upon receipt of CTA approval.

Oncology Pipeline

The Oncology pipeline continued to make good progress in the period, with the nomination of a drug development candidate for the reversible BTK inhibitor RXC005. We highlight the new candidate below, together with our Porcupine inhibitor RXC004.

Porcupine inhibitor (RXC004)

The initial development focus for RXC004 will be as a monotherapy for pancreatic, gastric and biliary cancer. These three types of cancer have a poor prognosis and the medical need for new treatments is compelling.

In November we presented novel efficacy data on our Porcupine inhibitor in combination with an anti-PD-1 checkpoint inhibitor. The synergistic effect between our compound and the anti-PD-1 antibody has encouraged us to implement a fourth combination arm into our Phase I clinical trial plan for RXC004.

Our RXC004 program in oncology is now awaiting CTA approval after which first-in-human clinical trials can commence.

Reversible BTK inhibitor (RXC005)

We are seeking to develop a "best-in-class" reversible inhibitor to treat primarily chronic lymphocytic leukaemia (CLL) patients who have become resistant to the currently used treatment, IMBRUVICA(R) (ibrutinib), which is an irreversible BTK inhibitor.

We selected a drug development candidate in October 2016 and have swiftly moved forward with IND-enabling studies with the aim to file a CTA/IND around year end 2017.

The rest of our oncology pipeline continues to progress well including our AstraZeneca collaboration, SHP2 program and programs against several other undisclosed targets.

Immunology

Our immunology team was established in May 2015. It is focussing on developing new therapies for disorders of the immune system and where possible seeks synergies with the work ongoing in our oncology team.

We have chosen fibrosis as a key research area. Therapeutic targeting of the WNT-pathway has utility in several fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF). Therefore we are actively investigating the use of Porcupine inhibitors to treat this and other fibrotic diseases.

We have also acquired a soft (locally acting) pan Rho-kinase (ROCK) inhibitor, AMA0825, from Amakem NV. This compound is in late lead-optimisation stage and is being studied as a potential treatment for inflammatory-bowel disease.

Anti-infectives

As part of the strategic refocussing announced in March we have decided to stop anti-infective research in-house but are looking for partnership opportunities to progress our various infection assets. In support of this we received a US$1 million grant from CARB-X, which can be used for a collaborative program to progress our Gram-negative NBTI program.

BOARD APPOINTMENTS

On 31 March 2017 Dr Peter Jackson, Non-Executive Director and co-founder of Redx stepped down from the Board. Dr Frank M. Armstrong, Non-Executive Chairman of the Board and Mr Peter McPartland, Non-Executive Director, did not stand for re-election at the Annual General Meeting for shareholders held on 20 April 2017, post period.

On 20 April 2017 the Company announced it has appointed Mr Iain Ross as Non-Executive Chairman of its Board, effective from 1st May 2017. Mr Ross has over 35 years' of experience having held Board and Senior Management positions at multiple public and private companies in the Life Sciences sector.

FINANCIAL REVIEW

The cash position at 31 March 2017 stood at GBP5.1m (31 March 2016: GBP4.4m). In March 2017 the Company successfully completed a placing, subscription and open offer of new ordinary shares at 37.5p, which raised GBP12m gross, which included a subscription with a related sharing agreement (as explained on p.3).

The total comprehensive loss for the period was in line with management expectations at GBP10.7m (2016: GBP7.1m).

OUTLOOK

Redx has an attractive pipeline of products focused on areas where there is significant market interest. We made good progress across our research programs in the first half and expect this to continue over the second half of the financial year, with a particular emphasis on driving forward our most advanced assets, including our Porcupine inhibitor compound towards initial clinical studies.

The Company remains well positioned to secure value from its assets, including securing further commercial partnerships, and to further develop the business.

 
 Iain Ross   Neil Murray 
 Chairman    Chief Executive 
 
 

Consolidated Statement of Comprehensive Income

 
                                         Unaudited      Unaudited         Audited 
                                         Half Year      Half Year         Year to 
                                             to 31    to 31 March    30 September 
                                             March           2016            2016 
                                              2017 
                                  Note      GBP000         GBP000          GBP000 
 
 Operating expenses                       (10,154)        (8,015)        (16,527) 
 Non recurring relocation 
  costs                                          -              -           (556) 
 Reorganisation costs                        (320)              -               - 
 Share based compensation          4           (3)          (111)           (245) 
 Other operating income                        642          1,484           2,380 
                                        ----------  -------------  -------------- 
 Loss from operations                      (9,835)        (6,642)        (14,948) 
 Finance costs                     5       (1,170)          (136)           (526) 
 Finance income                    5            19             34              67 
                                        ----------  -------------  -------------- 
 Loss before taxation                     (10,986)        (6,744)        (15,407) 
 Income tax                        2           293          (390)           (114) 
                                        ----------  -------------  -------------- 
 Loss for the period                      (10,693)        (7,134)        (15,521) 
 Other comprehensive                             -              -               - 
  income, net of tax 
                                        ----------  -------------  -------------- 
 Total comprehensive 
  loss for period attributable 
  to owners of Redx Pharma 
  plc                                     (10,693)        (7,134)        (15,521) 
                                        ==========  =============  ============== 
 
                                             pence          Pence           pence 
 Loss per share 
  - basic and diluted              3        (10.7)         (11.0)          (19.8) 
 

Consolidated Statement of Financial Position

 
                                       Unaudited   Unaudited        Audited 
                                        31 March    31 March   30 September 
                                            2017        2016           2016 
                                Note      GBP000      GBP000         GBP000 
 Assets 
 Property, plant and 
  equipment                                  386         369            533 
 Intangible assets                           426         309            309 
 Derivative financial 
  instrument                     6           894           -              - 
 Other receivables                           623         767            605 
 Total non-current 
  assets                                   2,329       1,445          1,447 
                                      ----------  ----------  ------------- 
 Trade and other receivables               1,481       1,083          1,553 
 Derivative financial 
  instrument                     6         1,788           -              - 
 Cash and cash equivalents                 5,106       4,394          5,758 
 Current tax                                 930         786            637 
 Total current assets                      9,305       6,263          7,948 
                                      ----------  ----------  ------------- 
 Total assets                             11,634       7,708          9,395 
                                      ----------  ----------  ------------- 
 Liabilities 
 Trade and other payables                  7,434       5,031          5,675 
 Borrowings                                2,000       2,000          2,000 
 Total current liabilities                 9,434       7,031          7,675 
                                      ----------  ----------  ------------- 
 Non-current liabilities 
 Non-current borrowings                        -           -              - 
                                      ----------  ----------  ------------- 
 Total liabilities                         9,434       7,031          7,675 
                                      ----------  ----------  ------------- 
 Net assets                                2,200         677          1,720 
                                      ==========  ==========  ============= 
 Equity 
 Share capital                             1,265         650            936 
 Share premium                            33,367      13,516         22,526 
 Share-based compensation                    870         733            867 
 Capital redemption 
  reserve                                      1           1              1 
 Retained deficit                       (33,303)    (14,223)       (22,610) 
 Equity attributable 
  to shareholders                          2,200         677          1,720 
                                      ==========  ==========  ============= 
 

Consolidated Statement of Changes in Equity

 
                             Unaudited   Unaudited     Unaudited   Unaudited   Unaudited   Unaudited 
                                 Share       Share   Share-based     Capital    Retained       Total 
                               capital     premium       payment    redemp'n     deficit      equity 
                                                                     reserve 
                                GBP000      GBP000        GBP000      GBP000      GBP000      GBP000 
 Movements by 
  half year 
 As at 30 September 
  2015                             650      13,516           622           1     (7,089)       7,700 
                            ----------  ----------  ------------  ----------  ----------  ---------- 
 
 Share options 
  lapse                              -           -           (7)           -           -         (7) 
 
 Transactions 
  with owners in 
  their capacity 
  as owners                          -           -           (7)           -           -         (7) 
 Loss and total 
  comprehensive 
  income for the 
  period                             -           -             -           -     (7,134)     (7,134) 
 Share-based compensation            -           -           118           -           -         118 
                            ----------  ----------  ------------  ----------  ---------- 
 As at 31 March 
  2016                             650      13,516           733           1    (14,223)         677 
                            ----------  ----------  ------------  ----------  ---------- 
 
 Share issue                       286       9,714             -           -           -      10,000 
 
 Share issue costs                   -       (704)             -           -           -       (704) 
                            ----------  ----------  ------------  ----------  ----------  ---------- 
 Transactions 
  with owners in 
  their capacity 
  as owners                        286       9,010             -           -           -       9,296 
 Loss and total 
  comprehensive 
  income for the 
  period                             -           -             -           -     (8,387)     (8,387) 
 Share-based compensation            -           -           134           -           -         134 
 As at 30 September 
  2016                             936      22,526           867           1    (22,610)       1,720 
                            ----------  ----------  ------------  ----------  ----------  ---------- 
 Share options 
  exercised                          1          69             -           -           -          70 
 Share issue                       328      11,966             -           -           -      12,294 
 Share issue costs                   -     (1,194)             -           -           -     (1,194) 
                            ----------  ----------  ------------  ----------  ----------  ---------- 
 Transactions 
  with owners in 
  their capacity 
  as owners                        329      10,841             -           -           -      11,170 
 Loss and total 
  comprehensive 
  income for the 
  period                             -           -             -           -    (10,693)    (10,693) 
 Share-based compensation            -           -             3           -           -           3 
 As at 31 March 
  2017                           1,265      33,367           870           1    (33,303)       2,200 
                            ==========  ==========  ============  ==========  ==========  ========== 
 

Consolidated Statement of Cash Flows

 
                                     Unaudited   Unaudited         Audited 
                                          Half   Half Year         Year to 
                                          Year       to 31    30 September 
                                         to 31       March            2016 
                                         March        2016 
                                          2017 
                                        GBP000      GBP000          GBP000 
 Net cash flow from operating 
  activities 
 Loss for the period                  (10,693)     (7,134)        (15,521) 
 Adjustments for: 
 Income tax                              (293)         390             114 
 Finance costs (net)                     1,151         102             459 
 Depreciation and amortisation             178         117             262 
 Share based compensation                    3         111             245 
 Movements in working capital 
 Decrease/(increase) in 
  trade and other receivables               71         324           (124) 
 Increase in trade and other 
  payables                               1,573         837           1,272 
 Cash used in operations               (8,010)     (5,253)        (13,293) 
 Tax credit received                         -         325             750 
 Interest received                           2          19              36 
                                    ----------  ----------  -------------- 
 Net cash used in operations           (8,008)     (4,909)        (12,507) 
                                    ----------  ----------  -------------- 
 Cash flows from investing 
  activities 
 Purchase of intangible                  (117)           -               - 
  assets 
 Sale of property plant 
  and equipment                              -           -               2 
 Purchase of property, plant 
  and equipment                           (31)       (133)           (444) 
 Net cash used in investing 
  activities                             (148)       (133)           (442) 
                                    ----------  ----------  -------------- 
 Cash flows from financing 
  activities 
 Proceeds from share issues             12,364           -          10,000 
 Share issue costs                     (1,194)                       (704) 
 Derivative financial instrument       (3,666)           -               - 
 Loan granted                                -           -            (25) 
 Net cash from financing 
  activities                             7,504           -           9,271 
                                    ----------  ----------  -------------- 
 Net decrease in cash and 
  equivalents                            (652)     (5,042)         (3,678) 
 Cash and cash equivalents 
  brought forward                        5,758       9,436           9,436 
 Cash and cash equivalents 
  carried forward                        5,106       4,394           5,758 
                                    ==========  ==========  ============== 
 

Notes to the Financial Statements

   1.          Basis of preparation and accounting policies 
   1.01       Description of Group and approval of the interim financial statements 

Redx Pharma plc ("Redx" or "the Company") is a limited liability company incorporated and domiciled in the UK. Its shares are quoted on AIM, a market operated by The London Stock Exchange. The principal activity of the Group is drug discovery, pre-clinical development and licensing.

The Group's interim financial statements are presented in pounds sterling, which is the Group's presentational currency, and all values are rounded to the nearest thousand (GBP000) except where indicated otherwise.

The interim financial statements were approved by the Board of Directors on 16 May 2017.

   1.02       Basis of preparation 

The Group's interim financial statements, which is unaudited, consolidates the results of Redx Pharma plc and its subsidiary undertakings made up to 31 March 2017. The Group's accounting reference date is 30 September.

The interim financial statements have not been audited and do not comprise statutory accounts within the meaning of section 434 of the Companies Act 2006 and have been prepared in compliance with International Accounting Standard ('IAS') 34, 'Interim Financial Reporting'.

Statutory accounts for the year ended 30 September 2016, prepared in accordance with International Financial Reporting Standards as adopted by the European Union (IFRS) and with those parts of the Companies Act 2006 applicable to entities reporting under IFRS, were approved by the Board on 20 March 2017 and delivered to the Registrar of Companies. The report of the auditors on those accounts was unqualified, did not contain an emphasis of matter paragraph and did not contain any statement under section 498(2) or section 498(3) of the Companies Act 2006.

   1.03       Significant accounting policies 

The accounting policies used in the preparation of the financial information for the six months ended 31 March 2017 are in accordance with the recognition and measurement criteria of International Financial Reporting Standards ('IFRS') as adopted by the European Union and are consistent with those which will be adopted in the annual statutory financial statements for the year ending 30 September 2017.

While the financial information included has been prepared in accordance with the recognition and measurement criteria of International Financial Reporting Standards (IFRS), as adopted by the European Union (EU), the interim financial statements do not contain sufficient information to comply with IFRS's.

Valuation of derivative financial asset

The Company has placed shares with Lanstead Capital L.P. and at the same time entered into equity swap and interest rate swap agreements in respect of the subscriptions for which consideration will be received monthly over an 18 month period as disclosed in the notes to these financial statements.

The amount receivable each month is dependent on the Company's share price performance. At each period end the amount receivable is restated based on the share price of the Company at that date. Any change in the value of the receivable is reflected in the income statement.

   1.04       Segmental information 

Operating segments are reported in a manner consistent with the internal reporting provided to the chief operating decision-maker. The Board of Directors and the Chief Financial Officer are together considered the chief operating decision-maker and as such are responsible for allocating resources and assessing performance of operating segments.

The Directors consider that there are no identifiable business segments that are subject to risks and returns different to the core business. The information reported to the Directors, for the purposes of resource allocation and assessment of performance is based wholly on the overall activities of the Group.

The Group has therefore determined that it has only one reportable segment.

   1.05       Going concern 

As part of their going concern review the Directors have followed the guidelines published by the Financial Reporting Council entitled "Guidance on Risk Management and Internal Control and Related Financial and Business Reporting".

The Group incurred a net loss of GBP10.7m during the period; however, the Directors are satisfied, based on detailed cash flow projections and after the consideration of reasonable sensitivities, that sufficient working capital is available to meet the Group's needs as they fall due for the foreseeable future and at least 12 months from the date of signing the interim financial statements.

The detailed cash flow assumptions are based on the Group's annual budget, prepared and approved by the Board, which reflects a number of key assumptions in addition to revenue forecasts, underpinned by the current pipeline.

Within the revenue forecasts, there are inherent judgements regarding the commercial and technical risk of programs. Whilst acknowledging the uncertainties in the operating environment and their resultant impact on revenues, the Directors have identified a number of opportunities to manage working capital, to mitigate against any deteriorations and uncertainties in trading.

On the basis of the above review, the Directors are confident that the Group has sufficient working capital to honour all of its obligations to creditors as and when they fall due. Accordingly, the Directors continue to adopt the going concern basis in preparing the interim financial statements.

   2.         Income tax 
 
                             Unaudited   Unaudited         Audited 
                              31 March    31 March    30 September 
                                  2017        2016            2016 
                               GBP'000     GBP'000         GBP'000 
 Current income tax 
 UK corporation tax (R&D             -           -               - 
  tax credits) 
 Research and Development 
  Expenditure credit             (293)       (277)           (637) 
 Prior year adjustment               -         667             751 
                            ----------  ----------  -------------- 
 
 Income tax (credit) 
  / charge per the income 
  statement                      (293)         390             114 
                            ----------  ----------  -------------- 
 
 

The Group is in continuing discussion with HMRC regarding the impact of RGF funding on the recoverability of R&D tax credits. Whilst the directors remain confident that such credits are fully recoverable, they consider it prudent not to provide on such a basis at the current time. Amounts due under Research and Development Expenditure credit are unaffected.

   3.      Loss per Share 
 
 Basic loss per share is calculated by dividing 
  the net income for the period attributable 
  to ordinary equity holders by the weighted 
  average number of ordinary shares outstanding 
  during the period. 
 In the case of diluted amounts, the denominator 
  also includes ordinary shares that would be 
  issued if any dilutive potential ordinary 
  shares were issued following conversion of 
  loans or exercise of share options. 
 The basic and diluted calculations are based 
  on the following: 
                             Unaudited    Unaudited      Audited 
                             Half Year    Half Year         Year 
                                 to 31        to 31        to 30 
                                 March        March    September 
                                  2016         2016         2016 
                                GBP000       GBP000       GBP000 
 Loss for the period 
  attributable to the 
  owners of the Company       (10,693)      (7,134)     (15,521) 
                                Number       Number       Number 
 Weighted average number 
  of shares 
  - basic and diluted       99,524,002   64,981,209   78,360,552 
                           ===========  ===========  =========== 
                                 Pence        Pence        Pence 
 Loss per share - basic 
  and diluted                   (10.7)       (11.0)       (19.8) 
                           ===========  ===========  =========== 
 
   The loss and the weighted average number of 
   shares used for calculating the diluted loss 
   per share are identical to those for the basic 
   loss per share. This is because the outstanding 
   share options would have the effect of reducing 
   the loss per share and would therefore not 
   be dilutive under IAS 33 Earnings per Share. 
 
   4.         Share-based compensation 
 
 Share options have been issued to certain 
  directors and staff during the period, and 
  the charge arising is shown below. The fair 
  value of the options granted has been calculated 
  using a Black--Scholes model. 
                                Unaudited   Unaudited      Audited 
                                Half Year   Half Year         Year 
                                    to 31       to 31        to 30 
                                    March       March    September 
                                     2016        2016         2016 
                                   Number      Number       Number 
 Options granted and vested 
  in period                             -           -       35,294 
 Options exercised in 
  period                        (145,319)           -            - 
 Options cancelled in 
  period                        (199,538)    (90,000)    (226,282) 
 Options granted and vesting 
  in future periods                     -   1,145,350    1,362,997 
                               ----------  ----------  ----------- 
                                (344,857)   1,055,350    1,172,009 
                               ==========  ==========  =========== 
                                   GBP000      GBP000       GBP000 
 Charge to Statement of 
  Comprehensive Income 
  in period                             3         111          245 
                               ==========  ==========  =========== 
 
 Assumptions used were an option life of 5 
  years, a risk free rate of 2% and no dividend 
  yield. Other inputs were: 
  Volatility 40% 
  Share price at date of grant in a range between 
  41.5p and 85p 
  Weighted average exercise price in a range 
  between 33p and 85p 
  Weighted average fair value of each option 
  in a range between 16.1p and 47.2p 
 
 
 
   5.         Finance expense and finance income 
 
 
                                Unaudited     Unaudited      Audited 
                                     Half          Half         Year 
                                     Year          Year        to 30 
                                    to 31         to 31    September 
                                    March         March         2016 
                                     2017          2016 
 
 Finance expense 
 Loan interest                        186           136          346 
 Fair value adjustment                984             -          180 
 
                                _________       _______      _______ 
                                    1,170           136          526 
                                _________       _______      _______ 
 
 Finance income 
 Bank and other short term 
  deposits                              1            16           32 
 Loan interest                         18            18           35 
                                _________       _______      _______ 
                                       19            34           67 
                                _________       _______      _______ 
 
   6.         Derivative financial instrument 

Financial instruments that are measured subsequent to initial recognition at fair value are grouped into three levels based on the degree to which the fair value is observable as defined by IFRS 7:

Level 1 fair value measurements are those derived from unadjusted quoted prices in active markets for identical assets and liabilities;

Level 2 fair value measurements are those derived from inputs, other than quoted prices included within Level 1, that are observable either directly (i.e. as prices) or indirectly (i.e. derived from prices); and

Level 3 fair value measurements are those derived from valuation techniques that include inputs for the asset or liability that are not based on observable market data.

The derivative financial instrument included in the Statement of financial position, which is classified as a Level 3 derivative financial instrument, is the fair value of the equity swap with Lanstead Capital L.P. ("Lanstead") in the amount of GBP2,682,000. This is disclosed as amounts due within and after one year.

In March 2017 the Company initially issued 11,500,000 new ordinary shares of 1p each ("Ordinary Shares") at a price of 37.5p per share to Lanstead for GBP4,312,500. The Company simultaneously entered into an equity swap with Lanstead for 85 per cent of these shares with a reference price of 50p per share (the "Reference Price"). The equity swap is for an 18 month period ending in October 2018. All 11,500,000 Ordinary Shares were allotted with full rights on the date of the transaction.

Of the subscription proceeds of GBP4,312,500 received from Lanstead, GBP3,665,625 (85 per cent) was invested by the Company in the equity swap.

Investment in the equity swap was a condition of the placing with Lanstead.

To the extent that the Company's volume weighted average share price is greater or lower than the Reference Price at each swap settlement, the Company will receive greater or lower consideration calculated on a pro-rata basis i.e. volume weighted average share price/Reference Price multiplied by the monthly transfer amount. As the amount of the effective consideration receivable by the Company from Lanstead under the swap agreements will vary subject to the movement in the Company's share price and will be settled in the future, the receivable is treated for accounting purposes as a derivative financial asset and has been designated at fair value through profit or loss, where it is included in financial expenses.

The fair value is determined by using the share price at the measurement date and a historical volatility calculated based on the remaining life of the swap. Historical volatility, the unobservable input in the fair value measurement, was 56.7% at 31 March 2017. A reasonably possible change in the volatility used would not lead to a significant change in the fair value of the instrument.

   7.         Related party transactions 

Balances and transactions between the Company and its subsidiaries, which are related parties, have been eliminated on consolidation and are not disclosed in this note. Transactions between the Group and other related parties are disclosed below:-

Trading transactions

The Group has purchased services in the normal course of business from the following companies related to individuals who are or were Directors of the Group:

Acceleris Capital Ltd - of which N. Molyneux is a Director

Norman Molyneux Consultancy Ltd - owned by N. Molyneux

Dr Frank M Armstrong Consulting Ltd - owned by F. Armstrong

The Group has provided services in the normal course of business to the following companies related to individuals who are or were Directors of the Group:

Redag Crop Protection Ltd - of which N. Molyneux is a Director. A loan has also been

granted as part of the sale of this company.

The Group has purchased arms length administration services from Mrs. J. Murray, who is the wife of N. Murray.

The Group has purchased other services, and has paid deal fees and commissions, in connection with external fundraising from Acceleris Capital Ltd. These are also set out below, and were charged to the share premium account.

The amounts outstanding are unsecured.

The Group has a loan of GBP623k due from Redx Crop Protection Ltd. N. Molyneux and N. Murray are shareholders in Redag Crop Protection Ltd, that company's parent undertaking.

   7.        Related party transactions (cont'd) 
 
                                Unaudited      Unaudited      Audited 
                                     Half      Half year         Year 
      Purchases from/(charges     year to    to 31 March        to 30 
          to) related parties    31 March           2016    September 
                                     2017        GBP'000         2016 
                                  GBP'000                     GBP'000 
 
 Redag Crop Protection 
  Ltd                               (126)           (69)        (163) 
 Acceleris Capital 
  Ltd                                  53             45           88 
 Acceleris Capital 
  Ltd (fundraising 
  items)                              111              -          309 
 Norman Molyneux Consultancy 
  Ltd                                   -             10           10 
 AMR Centre Ltd -                     (2)              -            - 
  consultancy 
 Dr Frank M Armstrong 
  Consulting Ltd                        2              3            5 
 Mrs J Murray                          12             12           24 
                                _________     __________   __________ 
                                       50              1          273 
                                _________     __________   __________ 
 
 
 
                                 Unaudited    Unaudited         Audited 
                                  31 March     31 March    30 September 
         Amounts owed to/(by)         2017         2016            2015 
              related parties      GBP'000      GBP'000         GBP'000 
 
 Redag Crop Protection 
  Ltd                                 (60)         (34)            (33) 
 Redag Crop Protection 
  Ltd - loan                         (623)        (767)           (605) 
 Acceleris Capital 
  Ltd                                   28            6              18 
 AMR Centre Ltd - 
  short term loan                     (25)            -            (25) 
 Norman Molyneux Consultancy             -           10               - 
  Ltd 
 AMR Centre Ltd -                        -            -               - 
  consultancy 
 Dr Frank M Armstrong 
  Consulting Ltd                         -            -               1 
 Mrs J Murray                            2            2               2 
                                __________   __________        ________ 
                                     (678)        (783)           (642) 
                                __________   __________        ________ 
 
 
   8.         Events after the reporting period 

There have been no significant events between the reporting date and the date of signing these interim financial statements.

INDEPENDENT REVIEW REPORT TO REDX PHARMA PLC

Introduction

We have been engaged by the Company to review the interim financial information in the interim financial report for the six months ended 31 March 2017 which comprises the Consolidated Statement of Comprehensive Income, the Consolidated Statement of Financial Position, the Consolidated Statement of Changes in Equity, the Consolidated Statement of Cash Flows and the related explanatory Notes 1 to 8. We have read the other information contained in the interim financial report and considered whether it contains any apparent misstatements or material inconsistencies with the interim financial information.

This report is made solely to the Company in accordance with International Standard on Review Engagements (UK and Ireland) 2410 "Review of Interim Financial Information performed by the Independent Auditor of the Entity" issued by the Auditing Practices Board. Our review work has been undertaken so that we might state to the Company those matters we are required to state to them in an independent review report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Company, for our review work, for this report, or for the conclusions we have formed.

Directors' Responsibilities

The interim financial report, is the responsibility of, and has been approved by the directors. The directors are responsible for the preparation and presentation of interim financial information that gives a true and fair view of the financial position of the Group as at 31 March 2017 and of the financial performance of the Group and the cash flows of the Group for six months period then ended in accordance with the applicable law and International Financial Reporting Standards and International Financial Reporting Interpretations Committee pronouncements as adopted by the European Union. The directors are also responsible for preparing and presenting the interim financial report in accordance with the AIM Rules of the London Stock Exchange.

As disclosed in note 1, the annual financial statements of the Group are prepared in accordance with International Financial Reporting Standards and International Financial Reporting Interpretations Committee pronouncements as adopted by the European Union. The interim financial information included in this interim financial report has been prepared in accordance with International Financial Reporting Standards and International Financial Reporting Interpretations Committee pronouncements as adopted by the European Union.

Our Responsibility

Our responsibility is to express to the Company a conclusion on the interim financial information in the interim financial report based on our review.

Scope of Review

We conducted our review in accordance with International Standard on Review Engagements (UK and Ireland) 2410, "Review of Interim Financial Information Performed by the Independent Auditor of the Entity" issued by the Auditing Practices Board for use in the United Kingdom. A review of interim financial information consists of making enquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures. A review is substantially less in scope than an audit conducted in accordance with International Standards on Auditing (UK and Ireland) and consequently does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion.

Conclusion

Based on our review, nothing has come to our attention that causes us to believe that the accompanying interim financial information does not give a true and fair view of the financial position of the Group as at 31 March 2017 and of the financial performance of the Group and the cash flows of the Group for the six month period then ended in accordance with International Financial Reporting Standards and International Financial Reporting Interpretations Committee pronouncements as adopted in the European Union and the AIM Rules of the London Stock Exchange.

RSM UK Audit LLP

Chartered Accountants

9th Floor,

3 Hardman Street,

Manchester,

M3 3HF

16 May 2017

FURTHER INFORMATION FOR SHAREHOLDERS

 
 AIM:                  REDX 
 Company number:       07368089 
 Investor website:     http://redxpharma.com/investors.html 
 Registered            Floor 9, Lowry House, 17 Marble 
  office:               Street, Manchester M2 3AW 
 Directors:            Iain Ross (Non-Executive Chairman) 
                       Neil Murray (CEO) 
                       Norman Molyneux (Non-Executive 
                        Director) 
                       Bernhard Kirschbaum (Non-Executive 
                        Director) 
                       David Lawrence (Non-Executive Director) 
 Company Secretary:    Simon Thorn 
 

END

This information is provided by RNS

The company news service from the London Stock Exchange

END

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May 17, 2017 02:00 ET (06:00 GMT)

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