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Share Name | Share Symbol | Market | Type | Share ISIN | Share Description |
---|---|---|---|---|---|
Evgen Pharma Plc | LSE:EVG | London | Ordinary Share | GB00BSVYN304 | ORD 0.25P |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 0.775 | 0.75 | 0.80 | 0.775 | 0.75 | 0.75 | 274,906 | 08:00:04 |
Industry Sector | Turnover | Profit | EPS - Basic | PE Ratio | Market Cap |
---|---|---|---|---|---|
Pharmaceutical Preparations | 422k | -4.04M | -0.0147 | -0.52 | 2.12M |
Date | Subject | Author | Discuss |
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08/6/2020 09:39 | Good stuff regarding the news on the Oncogene publication this morning SF discussed the significance of publishing this work back in January at the Evgen Investor meeting (see link to notes from meeting): | timbo003 | |
08/6/2020 09:11 | More news this week I reckon, news of the appointment of the new CEO coming soon along with potential Transformational funding news for SFX-01 patient trials for Covid-19. Gla :-) " And our recent clinical trial was life changing for some patients " January 2020 Next Steps Start the path to registration with an adaptive Phase IIb/III study – trial design to be developed in H1 2020 All preclinical breast data due to published in high impact journal early in 2020 Supplementary preclinical work to cement the right opportunity will commence early 2020 New “commercial ready” solid tablet formulation completed in H2 2020 Early partnering or sourcing of non-dilutive capital to fund the IIb part of the study in H2 2020 CTA/IND by end of 2020 Targeting first patient first dose H1 2021 | moneymunch | |
08/6/2020 07:02 | Evgen Pharma PLC Paper on SFX-01 in ER positive breast cancer 08/06/2020 7:00am RNS Non-Regulatory TIDMEVG Evgen Pharma PLC 08 June 2020 Evgen Pharma plc ("Evgen" or the "Company") Paper published on SFX-01 in ER positive breast cancer Evgen Pharma plc (AIM: EVG), a clinical stage drug development company focused on the treatment of cancer and neurological conditions, announces the publication of a scientific paper entitled " Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer". SFX-01 is the Company's synthetic formulation of stabilised sulforaphane (SFN). The paper, in the prestigious journal Oncogene, is co-authored by Bruno Simoes, Research Fellow at the Division of Molecular & Clinical Cancer Sciences, The University of Manchester and Sacha Howell, Honorary Consultant in Medical Oncology at the Christie Hospital. The paper describes a body of work carried out in a collaboration between Evgen and the University of Manchester, over a number of years, on the potential use SFX-01 to combat endocrine resistance in ER-positive breast cancer. The paper reports that SFX--01, used in combination with endocrine therapies, prevents breast cancer stem-like cell (CSC) enrichment in patient samples and patient-derived xenograft tumours. Thus SFX-01 reduces the formation of stem-like cells (thought to be the clones that survive once tumours are treated with therapies such as endocrine therapies, and which cause metastases). SFX-01 also blocks STAT-3, itself implicated in resistance to endocrine therapies. SFX-01 therefore has the potential to overcome such resistance and improve clinical outcomes. The paper can be viewed at: and on the Evgen website. Barry Clare, Executive Chairman of Evgen, commented: "This paper clearly elucidates the potential of SFX-01 in the treatment of ER+ metastatic breast cancer and its potential as a STAT3 inhibitor. We look forward to building on this work, and on the data from our successful phase II trial in metastatic breast cancer, in the next trial." | moneymunch | |
06/6/2020 08:57 | Another strong indication of SFX-01's potential for a Covid-19 treatment. Gla ;-) Broccoli florets have anti-inflammatory and antioxidant effects, due to inhibiting nitric oxide, which has been shown to play a role in inflammation. Sulforaphane also helps to fight inflammation, and the vitamin K in broccoli also helps reduce inflammatory markers in the blood. .................... COVID-19 Update: Vitamin K in Cheese Can Fight the Coronavirus; COVID-19 Patients Found to be Suffering From Vitamin Deficiency 5 June 2020 Tech Times As efforts to find a COVID-19 vaccine continue around the world, scientists continue to uncover new facts about the virus and what could prevent further infections. A new study has claimed that vitamin K found in some cheeses can fight the coronavirus. According to The Guardian's latest report, patients who have been admitted to intensive care with COVID-19 or those who died from the virus were discovered to have been suffering from vitamin K deficiency. The nutrient is often found in eggs, broccoli, spinach, and hard blue cheeses. According to their study, the degradation of elastic fibers in the lungs is caused by blood clotting created by COVID-19. The study claimed that vitamin K could protect the lungs against the viral disease since it helps the production of proteins that regulate clotting when ingested through food and absorbed in the gastrointestinal tract. Although the findings may provide promising results, Dr. Rob Janssen, a scientist working on the project, suggested that people can have a healthy intake of vitamin K except those who are on blood-thinning medications such as warfarin. "We are in a terrible, horrible situation in the world. We do have an intervention which does not have any side effects, even less than a placebo. There is one major exception: people on anti-clotting medication. It is completely safe in other people," Janssen explained. He added that even those who are not suffering from severe illnesses caused by the novel coronavirus should take vitamin K supplements since it can help strengthen their bones, blood vessels, and lungs. Janssen said that there are other vitamins similar to vitamin K; vitamin K1 and vitamin K2. K1 is found in broccoli, spinach, green vegetables, blueberries, and all types of vegetables and fruits. | moneymunch | |
05/6/2020 17:39 | The 100k trade is listed as Ordinary Non protected portfolio Single protected transaction Which suggests one institution to another. Gla :-) Ps The previous Rns 4/12/19 confirming Notice of Results was followed the next day by the Rns confirming news of the MoU with Dundee University , and the Evgen Investor Presentation was released the same day as the Half Yearly Results 17/12/19 and so I reckon there's a very good chance of an update on proceedings this coming week...fingers firmly crossed for a stellar Rns. :-) | moneymunch | |
05/6/2020 07:17 | Lol, me too, although it's conveivable that they may want to release some good news in time for the Results, a new CEO at the very least. Gl ;-) | moneymunch | |
05/6/2020 07:08 | Got a bit excited when I saw the RNS flag this morning, slightly deflated when I opened the RNS and saw what it was ! | mesquida | |
05/6/2020 07:05 | Notice of Results Evgen Pharma plc (AIM: EVG), the clinical stage drug development company focused on the treatment of cancer and neurological conditions, will announce its final results for the year ended 31 March 2020 on Monday, 15 June 2020. | moneymunch | |
04/6/2020 21:25 | Yep euclid5, the prospect of a more deadly second wave had already crossed my mind, mainly due to a documentary ( which was made pre Covid-19 ) I watched early in March about the Spanish Flu...the Yanks brought it over in their droves whilst being conscripted into WW1 ( although blamed Chinese migrant workers for its introduction to the US ) and spread to Europe and the rest of the world thereafter, only affecting the fittest generally between 18-40, and perhaps between 50 to 60 million died, and was called the Spanish Flu because they were neutral in WW1 and the US , UK and the rest did not report the pandemic because of the risk of lowering morale, and they reckoned the only reason the Germans lost WW1 was because that half of their army were infected by it....that said , always look on the bright side, maybe a vaccine will be found and or several therapeutic beneficial treatments....hopefu Ps Tee Off Time tomorrow- 10.20am - 4 Ball...:-))) | moneymunch | |
04/6/2020 21:00 | Second more deadly wave of coronavirus expected 'to hit Europe this winter' Europe's top WHO official warns that second spike could coincide with outbreaks of other infectious diseases European countries should brace themselves for a deadly second wave of coronavirus infections because the pandemic is not over, the World Health Organisation’s top official in Europe has said. In an exclusive interview with The Telegraph, Dr Hans Kluge, director for the WHO European region, delivered a stark warning to countries beginning to ease their lockdown restrictions, saying that now is the "time for preparation, not celebration". | euclid5 | |
04/6/2020 20:56 | Ps...Evg's HQ is in Wilmslow Cheshire....definite | moneymunch | |
04/6/2020 20:53 | Lol...or another Scouse git...ha ha ha :-) | moneymunch | |
04/6/2020 20:25 | Northwest residents, do they mean Canada, or do they mean Cumbria ! And is there any relevance in where they live ? | mesquida | |
04/6/2020 19:43 | We love your positivity moneymerch. We are routing too. A friend of a friend of friend (the usual script) ensures us of something big. Er, yep, we are northwest residents riding the wave with big smiles... It's a knuckle ride, but sit tight. | jamjamjam1 | |
04/6/2020 17:40 | Something Very BIG and Very positive is what my money is on. Gl ;-) | moneymunch | |
04/6/2020 17:22 | You mean positive or negative stirrings? Thanks | awise355 | |
04/6/2020 17:00 | have suspected - since the strangely executed/timed funding talks RNS - that there’s more to this than just that headline. Unless we’ve just had a string of coincidences but I don’t believe in them in the mkts. | bumpa33 | |
04/6/2020 16:38 | ps Toffeeman, what did you actually know about EVG when you jumped in at 15p ??? ;-) | moneymunch | |
04/6/2020 16:21 | Of course it's newsworthy ( it's only 5 weeks old and could be highly intersting for any newbies,not too sure of SFX-01's potential for Covid-19 ) and was posted in direct response to euclid5's post....Get a grip man!!! ;-) | moneymunch | |
04/6/2020 16:13 | I wish certain posters would not reprint old news. We are now in June and yet articles published in April are being reproduced on here as if they were newsworthy. Guys, the current price reflects everything that has been said and published. | lionheart69uk | |
04/6/2020 16:07 | Exactly right, but it's no surprise that SFX-01 is being considered for Covid-19 trials as sulforaphane appears to be a panacea for a multitude of diseases and ailments, including respiratory viral infections etc as per the following abstract and news release from the French bio Nutrinov who are specifically looking at sulforaphane as a treatment for Covid-19....Gl ;-) ................. (NADS in COVID-19 - short communication - version 1.1 - 1.5 A4 pages without references - 31.03.2020) Potent NRF2-activating dietary supplements (like resveratrol, curcumin, sulforaphane, “Asea redox supplement” [ARS] etc.) should be clinically tested as high-dose adjuvants in all types of medium and severe cases of aggressive respiratory viral infections (including Influenza A/B/C, measles, Coronavirus-related SARS, MERS, COVID-19) based on their extrapolated cytoprotective antioxidant effects Abstract This very short medical communication proposes that potent NRF2-activating dietary supplements (like resveratrol, sulforaphane, curcumin, “Asea redox supplement” [ARS] etc.) should be clinically tested as safe high-dose adjuvants (in various combinations) in all types of medium and severe cases of aggressive respiratory viral infections (including Influenza A/B/C, avian influenza, measles, Coronavirus-related SARS, MERS, COVID-19, etc., including those patients who have important comorbidities like HIV/AIDS, tuberculosis [TB] etc.) based on their extrapolated cytoprotective antioxidant effects (especially on the main vital organs: brain, heart, lungs, kidneys and liver), including the extrapolated strong cytoprotection offered by ARS on the cardiac muscle of DMD patients (which can be extrapolated to the lungs), like the author of this paper has demonstrated in past papers. Keywords: NRF2-activating dietary supplements, resveratrol, sulforaphane, curcumin, “Asea redox supplement” [ARS], respiratory viral infections, influenza A/B/C, avian influenza, measles, coronavirus, SARS, MERS, COVID-19, HIV/AIDS, tuberculosis [TB] ................ Coronanvirus: Nutrinov laboratory to launch research to evaluate the efficacy of sulforaphane Thursday April 30 Around the world, the race is on to find treatments for the coronavirus. Near Rennes, a laboratory specializing in health and nutrition wants to launch a clinical trial on sulforaphane, a natural compound with antiviral properties. Doctors often say, by being careful what you eat, people can ease their symptoms and heal faster. Several epidemiological studies have notably identified the important role of fruits and vegetables. A healthy diet and physical activity, for example, reduce the risk of cancer. Some substances are known for their antiviral properties. One of them is of particular interest to researchers and scientists in the Nutrinov laboratory located near Reindeer. He specializes in health and nutrition. Its researchers are particularly interested in sulforaphane, present in cruciferous vegetables such as broccoli and kale. It has several properties that participate in cell protection. It has also been shown to have antiviral properties. A prophylactic and curative effect against covid-19? "This molecule there, we know that it has antiviral, antibacterial and anticancer properties. We have done clinical studies with people who had prostate cancer. We have shown that it can help slow the evolution of pathology "explain Dr. Bernard Cipolla, surgeon oncologist in urology and Théo Efstathiou who heads the Nutrinov Analyzes & Research laboratory. "In terms of antiviral activity, we conducted another clinical study in 2014 on mice targeted to pulmonary edema. We injected the H1-N1 virus in mice. A fortnight before, we had given sulforaphane and we noticed a clear reduction in the symptoms of pulmonary edema "indicates Théo Efstathiou. Currently, there are no clinical studies on sulforaphane versus covid-19, "so we are forced to use therapeutic approaches based on previous research. Sulforaphane has been shown to be safe for consumption and that it is commercially available. I think it can be an important treatment available to the citizen in the current viral pandemic "continues the boss of the laboratory Nutrinov. Nutrinov and its researchers therefore hope to be able to launch a clinical study to assess the efficacy of sulforaphane against the current virus. | moneymunch | |
04/6/2020 15:51 | don't forget SGX-01 wasn't developed to deal with Covid 19 | euclid5 | |
04/6/2020 14:16 | " And our recent clinical trial was life changing for some patients " A pretty amazing result for any drug trial, which presumably ensures its continued development and subsequent funding which potentially could add significant value, news of which could arrive at anytime. As far as funding news for the potential Covid-19 trial for SFX-01, i'm sure most were hoping for news by now, although its perceived delay could be connected to the appointment of a new CEO, whereby they want the new leader in place before news on funding is released ( or at least both at the same time ) which would make perfect sense, rather than the other way around, and so hopefully not too much longer before all is made clear. Gla ;-) | moneymunch |
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