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CRX Cyprotex

160.50
0.00 (0.00%)
28 Mar 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Cyprotex LSE:CRX London Ordinary Share GB00BP25RZ14 ORD £0.01
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 160.50 0.00 00:00:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
0 0 N/A 0

Cyprotex PLC Launch of Solution to Predict Preclinical Toxicity

18/11/2015 9:16am

RNS Non-Regulatory


TIDMCRX

Cyprotex PLC

17 November 2015

Cyprotex PLC

("Cyprotex" or "the Company")

Launch of New Solution to Predict Preclinical Toxicity

17(th) November 2015;

Cyprotex PLC (AIM:CRX), a specialist Contract Research Organisation (CRO), announced today the launch of its new in silico modelling solution, chemTox, which predicts genotoxicity and rat LD(50) directly from chemical structure. The LD(50) is a commonly determined parameter in preclinical toxicity studies, representing the dose that causes death in 50% of the test group. Using models such as those in chemTox to predict this parameter will have obvious ethical benefits in reducing animal toxicity testing.

chemTox has been developed by Cyprotex's Scientific Computing Group using quantitative structure property relationship (QSPR) modelling, a technique that relates calculable chemical characteristics of a molecule to important properties such as its toxicity. As chemTox requires no experimental data inputs it can be used as a virtual screening tool prior to chemical synthesis. There are significant cost benefits to this approach as chemTox can be applied as an early stage filter for directing chemistry and prioritising subsequent in vitro screening by taking into account the predicted safety of the molecule. Cyprotex not only provide the in silico predictions but can provide a full tiered screening strategy with safety of the molecules substantiated using a panel of in vitro toxicity assays.

By utilising chemTox alongside complementary virtual screening tools such as chemPK(TM) , which was launched by Cyprotex in July, it is possible to predict both preclinical safety and human exposure in combination. Both systems operate on a similar KNIME workflow management platform which allows further integration with many other cheminformatics, analytics and modelling tools.

Dr Anthony Baxter, Cyprotex's Chief Executive Officer, comments: 'The ethical concerns over animal testing are intensifying and new approaches which reduce or in the future replace animal safety testing are a key focus. Virtual screening tools such as chemTox address this need, and are becoming widely used in industries such as cosmetics and personal care where a complete ban on animal testing has been enforced.'

For further information:

 
 Cyprotex PLC                         Tel: +44 (0) 1625 
                                       505 100 
 Dr Anthony Baxter, Chief Executive   ir@cyprotex.com 
  Officer                              www.cyprotex.com 
  John Dootson, Chief Financial 
  Officer 
  Mark Warburton, Chief Operating 
  Officer and Legal Counsel 
 
 N+1 Singer (Nomad and broker to      Tel: +44 (0)20 7496 
  Cyprotex)                            3000 
 Shaun Dobson                         shaun.dobson@n1singer.com 
  Jen Boorer                           jennifer.boorer@n1singer.com 
                                       www.n1singer.com 
 

Notes to Editors

About Cyprotex PLC

Cyprotex is listed on the AIM market of the London Stock Exchange (CRX). It has sites at Macclesfield and Alderley Park, both of which are near Manchester in the UK, and at Watertown, MA and Kalamazoo, MI in the US. The Company was established in 1999 and works with more than 1300 partners within the pharmaceutical and biotech industry, cosmetics and personal care industry and the chemical industry. Cyprotex acquired Apredica and the assets of Cellumen Inc. in August 2010 and the combined business provides support for a wide range of experimental and computational ADME-Tox and PK services. The acquisition of the assets and business of CeeTox in January 2014 has enabled Cyprotex to expand its range of services to target the personal care, cosmetics and chemical industries. In 2015, Cyprotex launched its new bioscience division to expand its capabilities into phenotypic and target based screening. The Company's core capabilities include high quality in vitro ADME screening services, mechanistic toxicology and high content toxicology screening services, including our proprietary CellCiphr(R) toxicity prediction technology, bioscience services, predictive modelling solutions, including Cloe(R) PK, chemPK(TM) and chemTox, and a range of skin, ocular and endocrine disruption services. For more information, see www.cyprotex.com.

This information is provided by RNS

The company news service from the London Stock Exchange

END

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(END) Dow Jones Newswires

November 17, 2015 02:01 ET (07:01 GMT)

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