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Final Results

Date : 22/03/2012 @ 07:00
Source : UK Regulatory (RNS & others)
Stock : Cyprotex (CRX)
Quote : 4.0  0.0 (0.00%) @ 07:36

Final Results

TIDMCRX

RNS Number : 8239Z

Cyprotex PLC

22 March 2012

22 March 2012

Cyprotex PLC

("Cyprotex" or the "Company" or the "Group")

Final results for the year ended 31 December 2011

Record year for Cyprotex

Cyprotex PLC (AIM: CRX), the preclinical ADME-Tox services company, today reports its final results for the year ended 31 December 2011.

Financial Highlights

   --        Revenues up 33.6% to GBP7.91 million (2010: GBP5.92 million) 

-- Continued profitability with operating profits up 203% to GBP0.67 million (2010: GBP0.22 million)

-- Underlying EBITDA^, an indicator of cash generation, remains consistently strong up 70% to GBP1.31 million (2010: GBP0.77 million)

   --        Profit after taxation up 42% to GBP0.88 million (2010: GBP0.62 million) 
   --        Earnings per share at 0.39 pence (2010: 0.31 pence) 

^ excluding share-based payment charge and expensed acquisition costs

Operational Highlights

   --      Won 157 new customers (2010: 81) including important strategic contracts 

-- Revenues associated with proprietary CellCiphr(TM) high content mechanistic toxicology technology exceeded GBP1.0 million (2010: GBP0.1 million)

   --      Increased revenue from new assays contributing GBP0.35 million in 2011 

-- Introduction of new genomic ADME (gADME(TM) ) technology to interpret genetic variation in drug metabolism and for the design of personalised dosing strategies

-- Successful delivery in partnership with Solvo Biotechnologia ZRT of a wide range of drug transporter services to Cyprotex clients, in response to recent FDA guidance

-- Extension of successful strategic alliance with Sygnature Discovery Limited to offer integrated drug discovery services

-- As a result of collaborative relationships with our strategic customers, significant improvements have been made to our pharmacokinetic prediction software, Cloe(R) PK, and our proprietary high content toxicology technology, CellCiphr(TM)

-- Major expansion with a near doubling of our US facility to meet growing demand in North America for Cyprotex's services completed in Q1 2012

   --      Increased front line sales team to five in total with three located in the US 

Steve Harris, Chairman of Cyprotex PLC, said:

"After two years of investment to enhance and expand our services and geographic footprint, our objective for 2012 is to leverage the competitive advantages we have created to drive revenue and profit growth. Cyprotex has now established itself as a thought leader in the ADME Tox field, with a strong position in the fast-growing in vitro toxicology market. Indeed, our laboratories in both the UK and US have had major expansions to accommodate increased demand. With these improvements to our services, together with the sector trend towards outsourcing R&D and the continued easing of the recession, we believe that Cyprotex is well placed for further strong growth."

For further information:

 
 Cyprotex PLC                                   Tel: +44 (0) 1625 505 
                                                 100 
 Dr Anthony Baxter, Chief Executive Officer 
  John Dootson, Chief Financial Officer 
  Mark Warburton, Chief Operating Officer and 
  Legal Counsel 
 ir@cyprotex.com                                www.cyprotex.com 
 
 Singer Capital Markets Limited (broker to      Tel: +44 (0) 203 205 
  Cyprotex)                                      7500 
 Shaun Dobson 
  shaun.dobson@singercm.com 
 Claes Spang 
 claes.spang@singercm.com                       www.singerscm.com 
 
 FTI Consulting                                 Tel: +44 (0) 20 7831 
                                                 3113 
 Simon Conway 
  Ben Atwell 
  Mo Noonan 
 cyprotex@fticonsulting.com                     www.fticonsulting.com 
 

Notes to Editors:

Cyprotex PLC

Cyprotex is the world's largest contract research organisation (CRO) specialising in ADME Tox, which is the analysis of the Absorption, Distribution, Metabolism, Excretion, and Toxicity properties of potential drugs, cosmetics, and agrochemicals. It is the only company in the world with in-house capabilities for both in vitro (test tube) and in silico (computer modelling) ADME Tox. Cyprotex was founded in 1999 and listed on the AIM in 2002. It has laboratories in Macclesfield, Cheshire, UK (near Manchester), and Watertown, Massachusetts, USA (near Boston), making it one of only three ADME Tox CROs with international operations.

Chairman and Chief Executive Officer's Report

Fruition of near-term strategic objectives bodes well for future growth

2011 was a year of substantial growth in both revenues and offerings for Cyprotex. Our entry into the in vitro toxicology market has proven to be very successful. In eighteen months, our toxicology revenues have risen from less than 6% to over 23% of our total revenues. Our 2010 acquisition of Apredica, which gave us a US operational platform, has proven timely as drug discovery investment in Europe has fallen and demand has shifted towards US-based organisations. As a result, the percentage of revenues Cyprotex receives from the US grew from 24% in 2009 to 44% in 2011. The strong growth of our toxicology and US business has necessitated a near doubling of our laboratory capacity in Watertown, Massachusetts, which was completed in January 2012.

We believe Cyprotex has now repositioned itself as a scientific thought leader in the ADME 'Tox' field. Cyprotex has demonstrated that we are able to rapidly commercialise cutting edge technologies that answer the most pressing needs of the pharmaceutical, agrichemical and cosmetic industries. These technologies are aimed at significantly improving the odds of developing safer, more efficacious drugs and other commercial chemicals faster and with considerations of specific needs to special populations. In 2010, we expanded into the nascent in vitro toxicology market. In 2011, we launched a novel genomic ADME (gADME(TM) ) service, opening a totally new market of interpreting genetic variation in drug metabolism. We also continue to develop new and innovative assays to match our customer's needs.

Our continued investment in the business during a period when the market has been weak and many of our competitors have been suffering has been a crucial strategic move. European and North American ADME Tox companies have been under increasing competition from Asia for the most common assays. Cyprotex's scientific innovation has allowed us to move into new markets where Asian competition is weak or non-existent, and where growth prospects are better. In doing so, this has provided a halo effect for our existing high-throughput ADME assays, enabling us to grow this business as well by selling these services to clients won on the basis of our newer, more scientifically advanced offerings.

Operational Performance

   --      Increasing diversification of customer base gives resilience to revenues 

-- Proprietary test offerings play well with pharmaceutical customers where pressures on R&D costs favour "fail early/fail cheaply" approaches

Market conditions have been gradually improving as the US works its way out of the current recession. While conditions are not as favourable as they were prior to the recession, we have begun to see signs of recovery.

We have strived to increase and diversify our customer base, shifting the business away from being dominated by a handful of overly large customers. Our current revenue exposure from any single customer is now down to 13%, versus 16% in 2010, 22% in 2009, and 34% in 2008. We have also expanded into new markets such as agrochemicals, cosmetics and supporting academic and charitable organisations. We believe this diversification has enabled Cyprotex to weather the economic downturn better than some of our competitors.

We are now experiencing a sea change in the drug discovery market. Larger pharmaceutical companies are cutting back sharply on in-house R&D. In some cases this is leading to wholesale site and programme closures. At the beginning of 2011, our second largest customer at the time closed three sites which caused a setback in our revenues. However, our strong growth rate has enabled us to fill the gap left by these closures in the first half of the year and by year-end, we were in-line with the market's expectations for total annual revenues.

Whilst the changes taking place in the pharmaceutical industry have some highly visible negative effects, it also produces positive opportunities for Cyprotex. R&D work that previously would have been performed in house is now being increasingly outsourced, as pharmaceutical companies have become reluctant to invest in R&D infrastructure. The trend towards outsourcing is both direct, through outsourcing of internal R&D programmes to Contract Research Organisations such as Cyprotex, and indirect, as drug discovery is increasingly shifting to smaller companies who are more likely to outsource than larger companies are.

As pressure on R&D costs mounts, pharmaceutical companies are increasingly turning to outsourcing as a solution and this increases the value of Cyprotex's services, by reducing cost and risk. Similarly, the increasing complexity of preclinical research entail equally sophisticated assays that require specialist equipment which is infrequently needed, or are proprietary, such as Cyprotex's gADME(TM) and CellCiphr(TM) assays. Such proprietary preclinical tests are gaining importance as the industry strives to limit the impact of drug discovery attrition with "fail early/fail cheaply" approaches gaining traction. Such newer complex assays are helping us gain business from customers that have historically been committed to in-sourcing. We believe that our scientific expertise and understanding of what our clients need, is helping us to gain traction in all areas of our business.

Financial Performance

Despite the reduction in revenue from our then second largest customer early into 2011, our underlying strong growth rate has enabled Cyprotex to increase revenues by 33.6% to GBP7.91 million, and to record a fourth consecutive year of profitability, positive cash flows from operations and with operating profits of GBP0.67 million (2010: GBP0.22 million).

The balance sheet remains strong with net assets up GBP1.1 million at GBP6.8 million (2010: GBP5.7 million) with the increase principally due to profitable trading.

The Group has invested over GBP0.58 million in R&D (2010:GBP0.56 million) including GBP172,500 in further developing CellCiphr(TM) technologies specifically targeted at improved automation of the predictive engine which has substantially reduced turnaround times allowing the Group to service much larger volumes. Revenues associated with CellCiphr(TM) technologies have contributed over GBP1.0 million to turnover which compares very favourably with last year at GBP0.1 million.

The Group continues to invest in equipment spending GBP0.31 million in the year (2011: GBP0.64 million) including adding a Xevo mass spectrometer to its analytical capabilities. Further investments are planned in 2012.

When non-cash items and acquisition costs are deducted, the underlying EBITDA recorded for the year was GBP1.31 million, up from GBP0.77 million in the previous year. This is a key indicator of the Group's ability to generate cash from operations. The Group's cash position at 31 December 2011 was GBP1.13 million (2010: GBP1.04 million)

Following an expansion of our sales team to manage the increased demand we are seeing, our headcount now stands at 70.

Outlook and Summary

After two years of investment to enhance and expand our services and geographic footprint, our objective for 2012 is to leverage the competitive advantages we have created. Cyprotex has now established itself as a thought leader in the ADME Tox field, with a strong position in the fast-growing in vitro toxicology market with laboratories in both the UK and US, both of which have had major expansions to accommodate increased demand.

In late 2011 we completed a recruiting effort to bring our sales team up to full strength. We have created a robust platform to focus our strategic emphasis towards revenue and profit growth whilst continuing to develop new and innovative offerings for our rapidly expanding customer base. With our enhanced strategic advantages and the continued easing of the recession, we believe that Cyprotex is poised for further strong growth.

 
 Steve Harris             Dr Anthony D Baxter 
 Non-Executive Chairman   Chief Executive Officer 
 

21 March 2012

Consolidated income statement

year to 31 December 2011

 
 Continuing operations         Note          2011          2010          2009 
                                              GBP           GBP           GBP 
 
 Revenue                       4        7,911,672     5,924,387     5,001,042 
 Cost of sales                        (1,327,968)     (868,068)     (649,319) 
                                     ------------  ------------  ------------ 
 Gross profit                           6,583,704     5,056,319     4,351,723 
 Administrative costs                 (5,912,523)   (4,834,461)   (3,893,074) 
                                     ------------  ------------  ------------ 
 Operating profit                         671,181       221,858       458,649 
 Finance income                             4,111         6,337        19,632 
 Finance cost                            (86,802)      (26,855)      (17,868) 
                                     ------------  ------------  ------------ 
 Profit before tax                        588,490       201,340       460,413 
 Income tax                               288,845       415,300             - 
                                     ------------  ------------  ------------ 
 Profit for the period                    877,335       616,640       460,413 
                                     ------------  ------------  ------------ 
  Attributable to 
 the owners of the parent                 877,335       616,640       460,413 
                                     ------------  ------------  ------------ 
 
 Earnings per share 
 Basic earnings per share      5            0.39p         0.31p         0.26p 
 Diluted earnings per share    5            0.39p         0.31p         0.26p 
 

Consolidated statement of comprehensive income

year to 31 December 2011

 
                                             2011      2010      2009 
                                              GBP       GBP       GBP 
 Continuing operations 
 Profit for the period                    877,335   616,640   460,413 
 Exchange differences on retranslation 
  of overseas operations                   82,149   (1,923)         - 
                                         --------  --------  -------- 
 Total comprehensive income for 
  the period                              959,484   614,717   460,413 
                                         --------  --------  -------- 
 
 Attributable to 
 the owners of the parent                 959,484   614,717   460,413 
                                         --------  --------  -------- 
 

Consolidated statement of financial position

at 31 December 2011

 
                                                                        2011          2010          2009 
                                                                         GBP           GBP           GBP 
 ASSETS                                                  Notes 
 Non current assets 
 Property, plant and equipment                           8         2,102,964     2,148,013     1,234,149 
 Intangible fixed assets                                 9         3,607,964     3,485,218             - 
 Deferred tax assets                                                 643,922       397,494             - 
                                                                ------------  ------------  ------------ 
                                                                   6,354,850     6,030,725     1,234,149 
                                                                ------------  ------------  ------------ 
 Current assets 
 Inventories                                                         349,780       290,126       166,714 
 Trade receivables                                                 1,095,801       809,153       605,706 
 Other receivables                                                   405,273       239,423       168,827 
 Cash and cash equivalents                                         1,127,680     1,036,888     2,074,132 
                                                                ------------  ------------  ------------ 
                                                                   2,978,534     2,375,590     3,015,379 
                                                                ------------  ------------  ------------ 
 Total assets                                                      9,333,384     8,406,315     4,249,528 
                                                                ------------  ------------  ------------ 
 LIABILITIES 
 Current liabilities 
 Trade payables                                                      331,974       183,060       144,998 
 Other payables                                                      563,959       415,914       225,916 
 Obligations under finance leases                                     81,532        98,101        10,729 
 Income tax payable                                                    7,800             -             - 
 Provisions                                                          149,000             -             - 
 Short-term borrowings                                               150,000       410,759             - 
 Current portion of long term borrowings                              67,100        30,000        30,000 
                                                                ------------  ------------  ------------ 
                                                                   1,351,365     1,137,834       411,643 
                                                                ------------  ------------  ------------ 
 Non current liabilities 
 Long term borrowings                                                614,400       506,400       541,100 
 Obligations under finance leases                                    108,727       113,924             - 
 Other borrowings                                                          -       150,000             - 
 Provisions                                                          176,155       474,100             - 
 Deferred tax liabilities                                            265,076       308,980             - 
                                                                ------------  ------------  ------------ 
                                                                   1,164,358     1,553,404       541,100 
                                                                ------------  ------------  ------------ 
 Total liabilities                                                 2,515,723     2,691,238       952,743 
                                                                ------------  ------------  ------------ 
 Net Assets                                                        6,817,661     5,715,077     3,296,785 
                                                                ------------  ------------  ------------ 
 EQUITY 
  Equity attributable to equity holders of the parent 
 Share capital                                           7           223,687       223,687       178,957 
 Share premium account                                            12,210,140    12,210,140    10,594,395 
 Other reserve                                                       128,070       128,070       128,070 
 Share based payment reserve                                         704,610       561,510       418,410 
 Profit and loss account                                         (6,448,846)   (7,408,330)   (8,023,047) 
                                                                ------------  ------------  ------------ 
 Total equity                                                      6,817,661     5,715,077     3,296,785 
                                                                ------------  ------------  ------------ 
 

Consolidated statement of changes in equity

year to 31 December 2011

 
                                  Share        Share      Other      Share          Profit       Total 
                                capital      premium    reserve      based             and      equity 
                                             account               payment    loss account 
                                                                   reserve 
                                    GBP          GBP        GBP        GBP             GBP         GBP 
 Balance at 1 January 
  2011                          223,687   12,210,140    128,070    561,510     (7,408,330)   5,715,077 
                              ---------  -----------  ---------  ---------  --------------  ---------- 
 Share based payments                 -            -          -    143,100               -     143,100 
 Transactions with owners       223,687   12,210,140    128,070    704,610     (7,408,330)   5,858,177 
 Profit for the period                -            -          -          -         877,335     877,335 
 Other comprehensive income           -            -          -          -               -           - 
 Exchange differences 
  on translation                      -            -          -          -          82,149      82,149 
 Total comprehensive income 
  for the period                      -            -          -          -         959,484     959,484 
                              ---------  -----------  ---------  ---------  --------------  ---------- 
 Balance at 31 December 
  2011                          223,687   12,210,140    128,070    704,610     (6,448,846)   6,817,661 
                              ---------  -----------  ---------  ---------  --------------  ---------- 
 
 
                                   GBP          GBP       GBP       GBP           GBP         GBP 
 Balance at 1 January 
  2010                         178,957   10,594,395   128,070   418,410   (8,023,047)   3,296,785 
                              --------  -----------  --------  --------  ------------  ---------- 
 Share based payments                -            -         -   143,100             -     143,100 
 Issue of share capital         44,730    1,632,656         -         -             -   1,677,386 
 Share issue costs                   -     (16,911)         -         -             -    (16,911) 
                              --------  -----------  --------  --------  ------------  ---------- 
 Transactions with owners      223,687   12,210,140   128,070   561,510   (8,023,047)   5,100,360 
 Profit for the period               -            -         -         -       616,640     616,640 
 Other comprehensive income          -            -         -         -             -           - 
 Exchange differences 
  on translation                     -            -         -         -       (1,923)     (1,923) 
 Total comprehensive income 
  for the period                     -            -         -         -       614,717     614,717 
                              --------  -----------  --------  --------  ------------  ---------- 
 Balance at 31 December 
  2010                         223,687   12,210,140   128,070   561,510   (7,408,330)   5,715,077 
                              --------  -----------  --------  --------  ------------  ---------- 
 
 
                                   GBP          GBP       GBP       GBP           GBP         GBP 
 Balance at 1 January 
  2009                         178,698   10,594,200   128,070   379,202   (8,483,460)   2,796,710 
                              --------  -----------  --------  --------  ------------  ---------- 
 Share based payments                -            -         -    39,208             -      39,208 
 Issue of share capital            259          195         -         -             -         454 
                              --------  -----------  --------  --------  ------------  ---------- 
 Transactions with owners      178,957   10,594,395   128,070   418,410   (8,483,460)   2,836,372 
 Profit for the period               -            -         -         -       460,413     460,413 
 Other comprehensive income          -            -         -         -             -           - 
                              --------  -----------  --------  --------  ------------  ---------- 
 Total comprehensive income 
  for the period                     -            -         -         -       460,413     460,413 
                              --------  -----------  --------  --------  ------------  ---------- 
 Balance at 31 December 
  2009                         178,957   10,594,395   128,070   418,410   (8,023,047)   3,296,785 
                              --------  -----------  --------  --------  ------------  ---------- 
 

Consolidated statement of cash flows

year to 31 December 2011

 
                                                 2011          2010        2009 
 Cash flows from operating activities             GBP           GBP         GBP 
 Profit after taxation                        877,335       616,640     460,413 
 Adjustments for: 
 Depreciation                                 363,553       269,686     261,259 
 Amortisation                                 140,199        53,959           - 
 Share based payment charge                   143,100       143,100      39,208 
 Finance income                               (4,111)       (6,337)    (19,632) 
 Interest expense                              86,802        26,855      17,868 
 Taxation recognised in the income 
  statement                                 (288,845)     (415,300)           - 
 (Increase)/decrease in trade and 
  other receivables                         (441,494)     (190,527)     446,880 
 Increase in inventories                     (58,819)      (80,499)    (48,157) 
 Increase/(decrease) in trade and 
  other payables                              263,327      (85,957)   (260,991) 
 Cash generated from operations             1,081,047       331,620     896,848 
 Interest paid                               (70,019)      (19,506)    (17,868) 
 Net cash from operating activities         1,011,028       312,114     878,980 
                                           ----------  ------------  ---------- 
 
 Cash flows from investing activities 
 Purchase of property, plant and 
  equipment                                 (312,610)     (640,075)   (313,746) 
 Expenditure on intangibles                 (172,543)             -           - 
 Acquisition (net cash paid)                        -     (339,482)           - 
 Interest received                              4,111         6,337      19,632 
                                           ----------  ------------  ---------- 
 Net cash used in investing activities      (481,042)     (973,220)   (294,114) 
                                           ----------  ------------  ---------- 
 
 Cash flows from financing activities 
 (Costs)/proceeds from issue of share 
  capital                                           -      (16,911)         454 
 Proceeds from long-term borrowings           200,000             -           - 
 Proceeds from finance lease obligations       83,766             -           - 
 Repayment of long-term borrowings           (54,900)      (34,700)    (34,400) 
 Payment of finance lease liabilities       (105,047)     (108,823)    (61,670) 
 Payment of contingent consideration        (156,060)      (10,900)           - 
 Payment of short term borrowings           (408,695)     (205,738)           - 
                                           ----------  ------------  ---------- 
 Net cash used in financing activities      (440,936)     (377,072)    (95,616) 
                                           ----------  ------------  ---------- 
 
 Net increase/(decrease) in cash 
  and cash equivalents                         89,050   (1,038,178)     489,250 
 Exchange differences on cash and 
  cash equivalents                              1,742           934           - 
 Cash and cash equivalents at beginning 
  of year                                   1,036,888     2,074,132   1,584,882 
                                           ----------  ------------  ---------- 
 Cash and cash equivalents at end 
  of year                                   1,127,680     1,036,888   2,074,132 
                                           ----------  ------------  ---------- 
 
 

Notes to the final results

year to 31 December 2011

   1.             Nature of operations and general information 

Cyprotex PLC ('Cyprotex') and subsidiaries' (together 'the Group') principal activity is the provision of in vitro and in silico ADMET/PK (Absorption, Distribution, Metabolism, Excretion, Toxicity/Pharmacokinetic) information to the pharmaceutical industry.

Cyprotex's vision is to provide, in partnership with our customers in drug discovery and development, the highest quality, fastest turnaround and most cost effective ADME and pharmacokinetic data to those customers.

Cyprotex PLC is the Group's ultimate parent company. It is incorporated and domiciled in England and Wales. The address of Cyprotex PLC's registered office is 100 Barbirolli Square, Manchester M2 3AB. The address of its principal places of business are 15 Beech Lane, Macclesfield, Cheshire, United Kingdom, SK10 2DR and 313 Pleasant Street, Watertown, Massachusetts MA 02472 USA. It trades through its wholly owned subsidiaries: Cyprotex Discovery Limited based in Macclesfield in the UK and Apredica, LLC in Watertown in the USA. Cyprotex PLC's shares are listed on the Alternative Investment Market of the London Stock Exchange.

The consolidated financial information set out in this announcement are presented in Pounds Sterling (GBP), which is also the functional currency of the parent. The consolidated financial information has been approved for issue by the Board of Directors on 21 March 2012.

The information in this preliminary announcement does not constitute statutory accounts within the meaning of sections 434 to 436 of the Companies Act 2006 and no statutory accounts have yet been filed with the Registrar of Companies for the year ended 31 December 2011. Statutory accounts for the year ended 31 December 2010 have been filed with the Registrar of Companies. The auditors report on these accounts was unqualified and did not contain an emphasis of matter, nor did it contain a statement under section 498 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2011 will be delivered to the registrar of Companies following the Company's Annual General Meeting.

The Group's statutory financial statements for the year ended 31 December 2010 and 31 December 2009, prepared under International Financial Reporting Standards (IFRS) have been filed with the Registrar of Companies.

Whilst the financial information included in this final results announcement has been computed in accordance with IFRS, this announcement in itself does not contain sufficient information to comply with IFRS.

   2.             Basis of preparation 

The consolidated final results are for the year ended 31 December 2011. They have been prepared in accordance with the requirements of International Financial Reporting Standards (IFRS) as adopted by the European Union (EU), including International Accounting Standards (IAS) and interpretations issued by the International Financial Reporting Committee (IFRIC) and applied in accordance with the Companies Act 2006. . Practice is continuing to evolve on the application and interpretation of IFRS. Further standards may be issued by the International Accounting Standards Board (IASB), and standards currently in issue and endorsed by the EU may be subject to interpretations issued by IFRIC.

The consolidated final results have been prepared in accordance with the accounting policies set out in the Group's statutory financial statements for the year ended 31 December 2010.

The accounting policies have been applied consistently throughout the Group for the purposes of preparation of this consolidated financial information.

   3.             Going concern 

The Group recorded a profit after taxation of GBP877,335 in the year ended 31 December 2011 and cash and deposits are GBP1,127,680. The Directors have reviewed the budget, financial forecasts including cash flow forecasts and other relevant information and believe that the Group has adequate resources to continue in operation for the foreseeable future.

   4.             Segmental information 

Revenue represents the amounts derived from the provision of goods and services which fall within the Group's ordinary activities and is stated net of value added tax and trade discounts.

The Group has a single operating and reportable segment, that of providing in vitro and in silico ADMET/PK (Absorption, Distribution, Metabolism, Excretion, Toxicity/Pharmacokinetic) information to the pharmaceutical and biotechnology industries. The revenue and operating profit for the year are derived from the Group's single operating and reportable segment. The Group has made an acquisition during the second half of the year ended 31 December 2010 which falls into this reporting segment.

The Group gives a geographic analysis of revenue by destination. Key markets for the Group are identified as North America, Mainland Europe and the United Kingdom.

 
                           2011        2010        2009 
                            GBP         GBP         GBP 
 United Kingdom       1,732,705   1,422,935   1,407,293 
 Rest of Europe       2,528,202   2,319,184   2,319,428 
 North America        3,484,408   2,099,855   1,191,308 
 Rest of the World      166,357      82,413      83,013 
                     ----------  ----------  ---------- 
                      7,911,672   5,924,387   5,001,042 
                     ----------  ----------  ---------- 
 
   5.             Earnings per share 

The calculation of the basic earnings per share is based on the earnings attributable to ordinary shareholders divided by the weighted average number of shares in issue during the period.

The calculation of diluted earnings per share is based on the basic earnings per share, adjusted to allow for the issue of shares and the post tax effect of dividends and/or interest, on the assumed conversion of all dilutive options and other dilutive potential ordinary shares.

Reconciliations of the earnings and weighted average number of shares used in the calculations are set out below.

 
                                                      2011          2010          2009 
 Continuing operations 
 Profit after tax and earnings attributable 
  to ordinary shareholders (GBP)                   877,335       616,640       460,413 
                                              ------------  ------------  ------------ 
 Weighted average number of ordinary 
  shares in issue (number used for 
  basic earnings per share)                    223,687,485   197,216,953   178,725,641 
                                              ------------  ------------  ------------ 
 Dilutive effect of options (number)               448,286       449,491       623,287 
                                              ------------  ------------  ------------ 
 Weighted average number of ordinary 
  shares in issue (number used for 
  diluted earnings per share)                  224,135,771   197,666,444   179,348,928 
                                              ------------  ------------  ------------ 
 Basic earnings per share (pence)                    0.39p         0.31p         0.26p 
                                              ------------  ------------  ------------ 
 Diluted earnings per share (pence)                  0.39p         0.31p         0.26p 
                                              ------------  ------------  ------------ 
 
   6.             Taxation 

At 31 December 2011, the Group has tax losses and deductibles totalling approximately GBP7.3 million that are available for offset against future profits arising from the same trade.

   7.             Share issues 

The authorised share capital of the Company was increased by 100,000,000 ordinary shares of 0.1p each to 300,000,000 on 14 July 2009. The Company has only one class of shares. During the year to 31 December 2011, no ordinary shares were issued. Shares issued may be summarised as follows:

 
                                                  Number       GBP 
 Year to 31 December 2011 
 At 1 January 2011                           223,687,485   223,687 
 At 31 December 2011                         223,687,485   223,687 
                                            ------------  -------- 
 Year to 31 December 2010 
 At 1 January 2010                           178,957,188   178,957 
 Issues of shares - purchase of Apredica, 
  LLC                                         44,730,297    44,730 
                                            ------------  -------- 
 At 31 December 2010                         223,687,485   223,687 
                                            ------------  -------- 
 Year to 31 December 2009 
 At 1 January 2009                           178,697,988   178,698 
 Issues of shares on exercise of share 
  options                                        259,200       259 
 At 31 December 2009                         178,957,188   178,957 
                                            ------------  -------- 
 
   8.             Additions and disposals of property, plant and equipment 

The following tables show the significant additions and disposals of property, plant and equipment.

 
 Year to 31 December    Long leasehold       Office     Computer   Laboratory 
  2011                   and buildings    equipment    equipment    equipment       Total 
                                   GBP          GBP          GBP          GBP         GBP 
 Carrying amount 
 at 1 January 2011             971,375       19,543       85,940    1,071,155   2,148,013 
 Additions                           -          272      110,280      202,058     312,610 
 Exchange                            -            -        2,285        3,609       5,894 
 Depreciation                 (21,562)      (5,025)     (46,832)    (290,134)   (363,553) 
                       ---------------  -----------  -----------  -----------  ---------- 
 at 31 December 2011           949,813       14,790      151,673      986,688   2,102,964 
                       ---------------  -----------  -----------  -----------  ---------- 
 
 
 Year to 31 December    Long leasehold       Office     Computer   Laboratory 
  2010                   and buildings    equipment    equipment    equipment       Total 
                                   GBP          GBP          GBP          GBP         GBP 
 Carrying amount 
 at 1 January 2010             809,471       20,322       38,388      365,968   1,234,149 
 Acquisitions                        -            -       28,340      508,603     536,943 
 Additions                     181,661        5,052       52,065      401,297     640,075 
 Exchange                            -            -          328        6,204       6,532 
 Depreciation                 (19,757)      (5,831)     (33,181)    (210,917)   (269,686) 
                       ---------------  -----------  -----------  -----------  ---------- 
 at 31 December 2010           971,375       19,543       85,940    1,071,155   2,148,013 
                       ---------------  -----------  -----------  -----------  ---------- 
 
 
 Year to 31 December    Long leasehold       Office     Computer   Laboratory 
  2009                   and buildings    equipment    equipment    equipment       Total 
                                   GBP          GBP          GBP          GBP         GBP 
 Carrying amount 
 at 1 January 2009             809,705       22,511       41,957      307,489   1,181,662 
 Additions                      17,665        3,373       28,576      264,132     313,746 
 Depreciation                 (17,899)      (5,562)     (32,145)    (205,653)   (261,259) 
                       ---------------  -----------  -----------  -----------  ---------- 
 at 31 December 2009           809,471       20,322       38,388      365,968   1,234,149 
                       ---------------  -----------  -----------  -----------  ---------- 
 
   9.             Intangible assets 

The following tables show the significant additions to intangible fixed assets.

 
                                                                Customer    Technology 
                                 Goodwill   Trade names    relationships    & know-how       Total 
                                      GBP           GBP              GBP           GBP         GBP 
 Cost or valuation 
 At 1 January 2011              2,562,302       188,125          318,125       470,625   3,539,177 
 Additions                              -             -                -       172,543     172,543 
 Exchange                          65,701         4,824            8,157        17,597      96,279 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2011            2,628,003       192,949          326,282       660,765   3,807,999 
                               ----------  ------------  ---------------  ------------  ---------- 
 
 Depreciation and impairment 
 At 1 January 2011                      -         7,839           26,510        19,610      53,959 
 Amortisation during 
  the year                              -        18,696           63,230        58,273     140,199 
 Exchange                               -           800            2,706         2,371       5,877 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2011                    -        27,335           92,446        80,254     200,035 
                               ----------  ------------  ---------------  ------------  ---------- 
 
 Net book value 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2011            2,628,003       165,614          233,836       580,511   3,607,964 
                               ----------  ------------  ---------------  ------------  ---------- 
 
 
                                                                Customer    Technology 
                                 Goodwill   Trade names    relationships    & know-how       Total 
                                      GBP           GBP              GBP           GBP         GBP 
 Cost or valuation 
 At 1 January 2010                      -             -                -             -           - 
 Acquisition of subsidiary      2,562,302       188,125          318,125       470,625   3,539,177 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2010            2,562,302       188,125          318,125       470,625   3,539,177 
                               ----------  ------------  ---------------  ------------  ---------- 
 
 Depreciation and impairment 
 At 1 January 2010                      -             -                -             -           - 
 Amortisation during 
  the year                              -         7,839           26,510        19,610      53,959 
 At 31 December 2010                    -         7,839           26,510        19,610      53,959 
                               ----------  ------------  ---------------  ------------  ---------- 
 
 Net book value 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2010            2,562,302       180,286          291,615       451,015   3,485,218 
                               ----------  ------------  ---------------  ------------  ---------- 
 At 31 December 2009                    -             -                -             -           - 
                               ----------  ------------  ---------------  ------------  ---------- 
 

Goodwill and other intangible assets relate to the acquisition of Apredica, LLC in August 2010,

Additions in the year relate to development work carried out on CellCiphr(TM) technologies.

   10.           The Annual Report 

The 2011 Annual Report and Accounts of the Group will be available to shareholders on the 1 June 2012. Copies will be available on request from the Company Secretary, Cyprotex PLC, 15 Beech Lane, Macclesfield, Cheshire, SK10 2DR.

   11.           Annual General Meeting 

The Annual General Meeting will be held at 10:00am on Tuesday, 17 July 2012 at The Royal Society of Medicine, 1 Wimpole Street, London, W10 0AE.

This information is provided by RNS

The company news service from the London Stock Exchange

END

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