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OXB Oxford Biomedica Plc

203.00
-2.00 (-0.98%)
19 Apr 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Oxford Biomedica Plc LSE:OXB London Ordinary Share GB00BDFBVT43 ORD 50P
  Price Change % Change Share Price Shares Traded Last Trade
  -2.00 -0.98% 203.00 259,276 16:35:17
Bid Price Offer Price High Price Low Price Open Price
202.00 203.00 208.00 200.00 202.00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Medicinal Chems,botanicl Pds 139.99M -45.16M -0.4676 -4.32 195.09M
Last Trade Time Trade Type Trade Size Trade Price Currency
18:07:04 O 10,241 203.00 GBX

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Date Time Title Posts
19/4/202418:55OXB. One owner, FSH Excellent conditionwith ejector seat7,562
13/3/202411:08Where we going945
13/2/202412:39Oxford Biomedica2,118
14/9/202310:29Open-minded posters thread576
26/4/202315:56OXB - sense and sensibility479

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Oxford Biomedica (OXB) Top Chat Posts

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Posted at 19/4/2024 09:20 by Oxford Biomedica Daily Update
Oxford Biomedica Plc is listed in the Medicinal Chems,botanicl Pds sector of the London Stock Exchange with ticker OXB. The last closing price for Oxford Biomedica was 205p.
Oxford Biomedica currently has 96,580,639 shares in issue. The market capitalisation of Oxford Biomedica is £195,092,891.
Oxford Biomedica has a price to earnings ratio (PE ratio) of -4.32.
This morning OXB shares opened at 202p
Posted at 19/4/2024 18:33 by harry s truman
Well, whatever the economic climate, pending world wars and our various theories on the "up a bit" / "down a bit" of the the OXB share price, a week today the run-up to the results is over and a week on Monday we turn a new page in the chronicles of OXB.

When they announced the date of the results, I noted the near 2 month notice of them (normally only weeks) and wondered if that was to allow them time to get something else in first. If there was anything to that idea then they have 5 days to spring something on us.

One point which occurred to me recently was that until Frank, results days were just that (the results) and some of those historic presentations were very quick. I can't remember one where they took the opportunity to announce something other than results on the same day.

Frank changed that last September when the interims also launched project Aquarius (the purchase of ABL Europe) and named some new partners who had been under the radar until then.

So, still possibilities for this week coming and certainly the prospect of an excellent FY presentation with some nice bonuses on top of what we have already seen guided.
Posted at 07/4/2024 13:10 by cousinit
In trying to get a handle on cash I've been looking at the statements made by Homology on their share of OXB Solutions. In the joy of accounting, OXB report the full Solutions result in their Group statements despite being the 80% majority owner.

It's not ideal as Homology report current assets for Solutions and the amount they owe them, so you probably end up with largely cash plus biologistics assets WIP/for sale rather than pure cash. OXB report cash separately.

Cash and cash equivalents for the OXB Group was £141.3m at Dec 22. Solutions had $39.2m of current assets at the same date and $5.2m owed by Homology. So, if that's assumed as cash, it equates to about £27.2m ((39.2-5.2)@1.25 FX). So OXB ex Solutions c.£114.1m.

At June 23, OXB Group cash was £129.4m. Solutions had $15.7m of current assets at the same date and $10.2m owed by Homology. So, if that's assumed as cash, it equates to about £4.4m ((15.7-10.2)@1.25 FX). So OXB ex Solutions c.£125.0m. So cash consumption looks like it was all focused in Solutions.

At the end of Dec 23, Solutions has $10.8m of current assets and $3.1m owed from Homology, so around £6.2m of cash ((10.8-3.1)@1.25 FX) so cash burn appears to have slowed markedly (although we know that Homology ceased development in July, so this may have been helped by receiving minimum revenues for not having to do a great deal in return.)

Obviously, there is a chance that OXB was moving cash around between the parent and Solutions during the year, but I don't get the impression that was happening (and I would hope that it would have been flagged if it was.)

Just on cash, we know that the OXB group cash was £121.4m at end of Aug 23 as that is contained in the going concern statement. It is not clear how much of the $10.2m owed by Homology at end of June to Solutions had been paid by then - Homology say that they aim to pay within 90 days.

Appreciate that this is all very spreadsheet-y, but it does suggest that cash burn at Solutions slowed in the second half of 2023 but analysts expect overall cash burn at the OXB group to be much higher in that period. We know the £10m restructuring costs were due to be incurred, but that's almost compensated by Solutions burning less.

I've also looked at revenues.
Posted at 04/4/2024 13:32 by harry s truman
Thanks Tuco.

I always try to stress somewhere that it's just an opinion, but of late the circumstantial evidence in favour of OXB seems overwhelming.

Appreciate I'm bringing coals to Newcastle with these points, but:-

What did Institut Merieux see which the market doesn't and why?

We have had the OXB explanation that IM basically wanted to build a mini French OXB before eventually deciding that "if you can't beat them, join them", but even so...

There is some "factor X" here with OXB which we take for granted but IM find compelling. Whether that was discovered through Roch, or Frank or Seb (who are of course French), or by IM's own surveillance, I guess we will never know, but if you look at the deal IM offered exclusively to us, then it's pretty much unprecedented.

They offered us Transgene's old manufacturing plant and labs in Strasbourg, along with the existing orderbook, and also the ABL labs in Lyon, again with their existing order book / workload, for 15m euros worth of shares printed at more than twice the market price at the time of issue (worth 6 million euros?). On top of that they are injecting 10m euro cash into ABL to ease it into exactly what OXB want to use the facilities for without costing OXB anything?

In a nutshell they have seen "factor X" which convinced them to give us something quite valuable for virtually nothing in exchange for becoming part of the OXB family.

Accept that and Institut Merieux who are very old hands in this business can obviously see something which the market doesn't yet see.

What the market does see (and this wasn't public before the IM approach and therefore can't have influenced them) is Seb's sales team selling work at such a pace that (certainly for early stage work) if it wasn't for Boston and the new ABL facilities then we would have to be either giving very long delivery lead times now or just turning work down - which is not normal or reflective of reported market conditions elsewhere.

OK, countering this we seem to have daily news stories now that the London Stock Exchange is finished, but regardless of how true that eventually turns out to be, you wouldn't expect it to undervalue a particular company because of where it is listed - especially as we have shares sold OTC on other exchanges - like OXB.DF in the US (and also have very supportive US analysts like Joe at HCW).

Time and time again I come back to the same point which is this combination of OXB being seen as a pandemic vaccine stock / being under the radar as a smallcap / being too difficult to understand / having evolved or reinvented itself too many times. When you couple all that with the fact that they will soon announce a very big loss for last year in the same presentation which they will forecast breakeven (hopefully better) for this year, then you can sort of understand the very sceptical approach from the likes of Numis, which is of course "OK, but we'll wait and see thanks".

9 covering brokers on OXB's website. I think I'm correct in saying that only one has revised based upon recent events, with the rest waiting for the FY results presentation before crunching the numbers and revisiting.

If that presentation achieves what we hope then all the analysts should up their targets so that the consensus moves much closer to RBC's figure, because at the moment that 180p target from the low analyst and 5 of the covering 9 rating OXB only as "hold" is doing us no favours at all.
Posted at 04/4/2024 11:09 by harry s truman
As brief as I ever can be here, I honestly think that OXB is one of those shares which is too difficult for most laypeople to get their heads around.

So, if you are a steelmaker or a goldminer or a telecoms company or a clothes retailer, then the market can compartmentalise you very quickly, there will be lots of analysts who understand your business really well, the investors can associate your business with what you do, and it goes on.

As our current CEO says (remember, this is a 60+ year old very successful CDMO exec), he wasn't really aware of OXB until the pandemic. If that's true of an industry insider, then what OXB did (did very well, but that's sort of irrelevant) was so niche that very few people had even heard of them, let alone understood their business - until the pandemic, which even then actually gave them a "name" for doing something else other than their speciality.

Up until May 2013 OXB is a biotech company. Primarily gene delivery. Very difficult to value a portfolio of research and trial drugs for such a specialised area.

May 2013 until the end of 2023, OXB is this almost unique hybrid company which was biotech drug development for our own drugs + service provider for the likes of Orchard, Novartis, BMS, etc., which totalled 25 as of the interims last year. Really difficult to find another company like that to compare to (biotech research / drug discovery in gene delivery for themselves + CDMO service provider for 25+ others).

In less words, there are many CDMOs to compare to and a huge number of biotech companies, but if anyone can find a gene delivery biotech company which is also a CDMO then I'll give them today's spot prize. So what do they compare to?

From the end of 2023 onwards OXB is no longer biotech and has stopped the development spend on its own in house drugs, so is now a pure play CDMO which should be much easier for the market to understand.

The trouble with the last point here is that the other CDMOs we can all name (Lonza, TF, Samsung, Catalent, Charles River, etc.) all have wide portfolios. By that I mean they make biologics, small molecule, tablets, anything which they can make money producing, and usually tagged onto the end of that business is a CGT (cell and gene therapy division) which does viral vectors and such (like OXB).

OXB is a pure play CGT CDMO, which as some of you will remember from a recent webcast, Seb seemed to imply is only us. So yet again, albeit unintentionally, OXB might have ended up in a position where the market is looking for something to compare against and struggling.

I think this is our major issue - under the radar and too difficult to understand.

The pure play CGT will either be a blessing or a curse. If it works out well then the gearing will be amazing as our whole business is tied to a market which is predicted to explode and OXB themselves say they see 1,600+ potential customers.

Should that market prediction go the way of the nuclear powered vacuum cleaner then obviously it wouldn't be as good, but what is the likelihood? On just one drug we provide an essential vector for, over 6,000 people have already received the cancer treatment for a disease stage which was previously untreatable. That market is here now.

In the past I've mentioned many times a rough / rule of thumb sector average for CDMO of 5.5x sales as a company valuation. It's not perfect, just a ballpark, but on the "low end" £126m forecast for this year, OXB should be around £700m or 70p per share. On the high end of the forecast £134m would be as near as doesn't matter to RBC's mid 12 month target of 740p. I heard the other day that someone had now put out 770p, but I don't know who that is.

This year the analysts have to start valuing us as a CDMO. The new problem (for the analysts) as I mention above, is that the sector average covers companies making everything from over the counter drugs costing a few pounds to million dollar personalised treatments. It's an average, but CGT should be weighted higher.

As it stands today, with a £200m market cap OXB is trading on 1.5x this year's forecast sales. There's obviously something very wrong with the rating there.

Personally I think OXB eventually ends up much more than the sector average, simply because of the speciality (and forecast need) of what they do very well.

For the moment though, we remain under the radar, ill understood outside of our industry / customers, and still labelled as a pandemic stock (post pandemic).

I'm hopeful that 4 weeks on Monday OXB kill that perception.

It will be the first time Stuart talks about 2025.
They will stress that the drug discovery business ended with the 2023 loss.
The coverage of the results will be of a CDMO company with a good forecast for 2024.

So, the argument against any biotech is always "jam tomorrow" (good results at the end of the next / current trial). OXB are not a biotech company any more.

They are a pure play CGT CDMO and will give forecasts for this year and next. Next being record revenue which will beat the pandemic vaccine revenues which were quoted by everyone as being exceptional.

I can't see them paying a dividend until the loan is repaid and the last 20% in Boston is ours. At that point then I guess it's on the cards, but if you look at Lonza then it's not a big dividend. If OXB pull in the numbers which they are projecting (over £300m by 2027) and if the multiple placed on OXB by the market reflects them being pure CGT in that market, then I don't think anyone sat on those shares would mind the lack of dividend.
Posted at 18/3/2024 11:57 by harry s truman
5.5x sales isn't a model Brucie, it's just a historic sector average of what a CDMO company should trade on - so a very rough guide. There is a progressively more accurate way to gauge, involving EV and such, but when OXB's value is so low, does that even matter? No, it's just a comparison.

In a similar way using a sector average for CDMO is only very approximate as a lot of people in CDMO are making generic otc medicines which there is only money in on huge volumes. CGT is far more lucrative and so the rating can (with some justification be double the average) - but you don't see me do that do you?.

It's like the breakeven figure for OXB, or the amount they need to sell to cover their costs, and OXB have told you previously everything you need to know to have a good stab at working that out.

You know that c£90m last year wasn't enough, but you can't look at the loss because some of that was for other stuff besides operations (capex on expansion in the US, £10m on redundancies and such), but you can remember that OXB said that on 130% of c£90m OXB would be broadly breakeven this year.

Since then the ball has rolled on, but ABL was said to be neutral in its pre-OXB life and our growth is now up another 5%.

In the simplest terms though, last September OXB told you that c£117m (c£90m x 1.3) would be broadly breakeven this year and a fortnight ago they told you that this year is now projected to be a FY2024 revenue range of £126 million to £134 million.

They really have showered us with detailed news of late, which is there for anyone who wants to look.

Yes there will be costs to bring ABL into the OXB family, but IM are paying those - and are apparently very happy to do so.

If, (if, if, if) the margin on c£117m in sales covers OXB's wage bill, leases, interest payments, utility charges and everything else this year, then what they sell above that is basically margin to the bottom line less raw material costs, consumables, packing, logistics and such - isn't it?

But what I have written there isn't new or news - we have known an evolving story since September that they are selling an unprecedented amount of work. At each update that has got better.

I might have to wait until after the interims and I might not, but personally I'm convinced that barring some exceptional negative event, OXB will be back in the FTSE250 this year.

I think though that we've all set our stalls out now though, and that nothing we type here changes anything anyway - so perhaps the best policy is to wait for news now, whether that be on the 29th of April or before.
Posted at 11/3/2024 21:03 by harry s truman
We've done the cash position a lot Brucie. £103.7m cash - c£40m loan - c£20m put option + c£17m from IM for new shares + whatever else comes our way this year. Nett cash is brilliant assuming that OXB hit their guidance of rough breakeven (or better).

Redwing,

I type what I think as an OXB watcher and usually caveat that somewhere. It's an opinion from a non-expert non-city type.

Maybe you know story well, apologies for the quick repeat if you do, but OXB were doing well before covid. CAR-T and a lot of other good stuff had lined up for them. Then came covid and clinical trials stopped (apart from covid related) and stuffed many of OXB's customers. We got vaccine work but when that ended early for political reasons a lot of our pre-pandemic work hadn't come back and we had 2 years where but for the huge cash balance we would have been stuffed too.

Read the recent releases and OXB's current situation is that not only is the work back now, but Seb's sales team is winning such an amount of work that we are already surpassing all pre-covid years and of course we wouldn't be sending excess work to America if Oxford wasn't at capacity.

Even on RBC's current assessment of OXB's public targets, so basically RBC being conservative about OXB's "achievable" guidance (i.e. effectively 2 cautious discounts applied there), their future is very bright (740p target this year).

Listen to Stuart in the webcasts last year about the guidance where he says 3 year revenue CAGR better than 30%, EBITDA margin better than 20%. But he stresses that these are very achievable targets which they expect to better.

What did he say in the update last week? Three-year revenue CAGR increased to more than 35%, up from prior guidance of more than 30%.

Expect to better 30% becomes more than 35% in six months?

Just my opinion here but based upon the above I honestly believe that OXB are in a position now where they are looking at the amount of work Seb's team is winning and thinking "this is brilliant, but after the last 2 years if we give projected guidance for the full story straight away then they'll never believe us".

So they are dripping it out in incremental stages (as shown above) and people like yourself are still thinking that it's too good to be true - which is fair enough.

Stuart says roughly breakeven for OXB this year, but there are of course many things lurking which could make that guidance redundant too.

Just another bit about the new house broker. RBC in their note last week have that revised target of 740p for this year, and of course you perhaps already know their 3 year fair value of £18, with both actually being discounted figures to reflect RBCs caution that OXB can achieve what they have guided for this year. RBC say that they will revise upwards as we progress through the year if and when OXB demonstrate that they are hitting their targets.

Their upside scenario for this year is significantly more than 740p and the upside target simply represents OXB delivering on everything the guidance in their public plan targets. OXB have said this is very achievable and they expect to better it.

I'm actually much more optimistic about the future than I might come across (yes, really). I also believe that OXB after the last interim results that, without the optimistic future plan + ABL deal, would have been simply been seen as missed previous guidance, are now giving guidance which is definitely not going to become another missed target - i.e. it's expectation over hope.

But what if some of the big hopes come in? I guess that's a different topic.

At the moment RBC are showing professional conservatism and I like that. I like it even more that their idea of conservatism is a target price of 740p this year.

In the absence of any other news, the presentation on the 29th April should show another 2 months of progress.
Posted at 07/3/2024 20:59 by harry s truman
I appreciate that, but I'm not really sure how it all happened. I want to think that an earlier thread formed the habit because there were a lot of good sorts around (even doc - our arch nemesis - was positive back then) but as you will have worked out I don't do this with my other shares. Could simply be the time invested too (rather than the money). I suppose everybody needs a hobby.

Anybody still around from the early days (and there are a few) I think we all have a very realistic view about our shares bought back then. I never owned OXB when they were AIM (that is before me) but I'm pretty sure they were floated at 100p and ended up higher when they joined the main exchange. Since then it's been a bit of a rollercoaster, but remember the 50 to 1 consolidation?

I have great optimism for the future of OXB and by that I don't mean the revenue or earnings which they have forecast for 2026.

Some of this revolves around the people who have come to OXB. Frank is 61 or 62 and had a brilliant job as CEO of Rentschler Biopharma (large private CDMO). They liked him and he has stayed on as a director there, so what is the logic for a guy nearing retirement to leave an excellent position for the same role in a UK company which had been severely battered post-covid.

I think we can discount both weather and food as attractions for a Frenchman, so why did he choose to come / what was the attraction? I suspect not the money as 6 or 7 years as CEO of Rentschler will have him extremely comfortable already.

So why come? And then Mark (our new US site boss) previously Vice President, Site Head for CDMO Rentschler Biopharma. No prizes for guessing how Frank knew what he could do, but again - left a good job to come to us?

Seb was VP CDMO for Merck and Thierry a similar very good job with Merck.

These guys all have great CVs / track records and yet they came to a company where if they looked at the losses before they came, or the share price chart?

The only thing which makes sense to me is that Frank wants to go into his eventual retirement on the back of creating something rather special and OXB is his chosen vehicle.

Seb Joined before Frank, but Frank brought the other two in and these guys all know how to do this (make millions in successful CDMO).

The fact that Seb, Frank and Thierry are all native French speakers is invaluable for how ABL develops - and there is a huge amount of potential there. Mark in the US has a facility roughly the size of OxBox, so with similar potential.

Frank's job is to now make sure everything OXB owns pays for itself and I think he's already made a very good start.

You will have seen me before mention our three 1,000 litre bioreactors in Oxford (we have many more smaller), there are three 500 litre bioreactors in Boston, three 200 litre bioreactors in Lyon and one in Strasbourg.

Ignoring all the smaller equipment for process development and pilot scale work (which as we know is very busy) that's an awful lot of capacity for volume production which at the moment has demand nowhere near capacity. I'm certain that will be somewhere near the top (if not the top) of Frank's to do list.

Get the downstream side of OXB at anything near the current utilisation of our process development / upstream equipment and I think you would be surprised at what OXB can earn.

1,000 litre bioreactors bought for covid vaccine bulk production are probably never going to be used in CGT CDMO work, but they are ideal for mass production of another vaccine. In time we will discover the plan, but using those again could be such a big earner.
Posted at 07/3/2024 11:25 by cousinit
Just on the price of 407.4p. On the day the IM/ABL deal was originally announced, analysts were very complimentary on how low the cost of acquisition was for OXB.

Clearly they might not have crunched the numbers on all aspects in the overall context that quickly, but it does give some comfort that OXB didn't have to overpay.

Was the headline deal value more a factor of the OXB share price? The key deal terms may actually have been the stake size IM took in OXB and the price of 407.4p was just a reflection of where the shares had been trading in the months preceding the acquisition?
Posted at 06/3/2024 15:23 by harry s truman
Philly,

The notes are for private clients of RBC or similar people (I am neither). If you search on "Oxford Biomedica RBC" then lots of the financial websites (morning star and such) listed a revised RBC target of 740p for OXB yesterday.

Certain of the the notes you can buy from websites like Zacks, but not the RBC note. I'd reassure you here that there are no market sensitive secrets in any of them, it's just an opinion based upon a chat with OXB's management. For the ordinary PI then imho they are reassuring but not really relevant. For a professional then it saves a lot of time to pay someone else for some collated information.

The long term targets aren't really forecasts, they are just a suggestion of what fair value would be if OXB's 3 year plan (as described to us too) works out.

So (to give one example) at the moment we are doing a lot of early stage work. Some of that will come to nothing, either because in early trials the idea just doesn't work or because the customer decides it's too big of a risk or any number of reasons.

But, a percentage of our early stage customers will progress to become later stage customers which means more work of a different kind and more money.

Nobody really knows what that percentage is. So there is a guess based upon experience / industry knowledge that xx% of them will progress to later stage work and that is where the future 1,800p fair value comes from.

If that assumed percentage progresses to later stage and early stage remains at capacity with new demand then 1,800p.

If the percentage progressing to the next stage is less than assumed and demand for early stage wanes, then it will be less than 1,800p if the actual percentage is higher and early stage demand remains high then it will be more than 1,800p.

Nobody knows how that will turn out yet, though we have all seen press stories predicting future market sizes for gene therapy. This is very much a pay your money / take your choice type deal - and remember that one of the brokers (I think Liberium) actually has a 12 month target price of less than today.

I suspect some of these people are not going to be convinced until OXB posts H1 results to prove their worth sometime in September.

I've watched OXB drop after good news many times before and so it wouldn't surprise me if it happens again over the next few weeks.

A base value for OXB as a CDMO should be 5.5x revenue. Important to note that's not how much work they can sell in a year, more what they can complete and bill for - so, to take last year they sold £131m of work but invoiced c£90m within the year.

£90m x 5.5 = £495m. There are roughly 100m shares so a fair price should have been at least 495p, which it was for a lot of last year until some US funds started selling in August (from which we have yet to recover).

In the RNS yesterday OXB said their projected revenue for 2024 (so not might or possibly, but expected) will be in the range of £126 million to £134 million.

Same 5.5x multiple would be a market cap of £693m to £737m.

£737m market cap / 99,957,395 shares is as near to 740p as doesn't matter, but I'm sure RBC put more effort into their target than that.

I've waited a long time and I can continue to do so. The big worry seems to be that OXB will get bought out cheaply, but my opinion is that NN, Vulpes, Serum and now IM would just say no. With all those shares out of the equation then it's probably a non-starter and I'm sure predator companies will have looked.

Of more interest to me is not the reassurance of what OXB have now told us, it's more what they "might" do (basically all the guesses in the post above and much more which we can't guess at). OXB have three 1,000 litre bioreactors in Oxford which were bought at a cost of millions for the covid vaccine work which then paid for them many times over. Since covid they have seemingly done nothing. If OXB can find a post-covid use for those then the scale of what they would produce makes them very lucrative pieces of equipment, even if the unit / dose cost of what they produce is very low.

An example there of why a 3 year target isn't really a target - too much can happen to change it. Here and now though, we have started a year very well which OXB are confident will be a good one. For us now, it's wait for the next news - which is expected end of April (Monday 29th) but might be before with something unexpected.
Posted at 05/3/2024 19:03 by harry s truman
takeiteasy,

re your question in #7155, then first I want to stress with a wealth warning here that I'm not any kind of financial expert. If I was then I would have sold all my shares at more than £15 and bought them back again at less than £2. I didn't.

I really want to weasel out with an answer which says I think it's a sum of the parts and it's all important, but in reality it has to be the cash burn.

Just over a year ago Stuart said at the JPM conference that after they had reorganised the business then they would effectively have "an infinite cash runway" as they wouldn't be spending cash on operations - and - whilst they did have plans to spend cash on capex for expansion and such, that is discretionary - meaning of course that if the demand wasn't there to make it pay back then they wouldn't do it.

It's stating the obvious I know, but sat on a huge pile of cash and not needing to dip into it for day to day operations is a very good place to be in any economy, but in this one it is brilliant.

I hear that RBS have simultaneously issued their first note as house broker today to coincide with OXB's financial update and raised their short term share price target to 740p with a 3 year target of 1,800p. Nice as the 3 year target is there, a lot can happen between now and 2017, so that's just really a marker. As I've mentioned a lot, my own target is back into the FT250 this year and I believe that is very achievable.

I'm assuming that if OXB have now briefed RBS (and how else would they produce the note?) that the other 8 covering brokers will already now have the same story or will hear it soon. With that in mind then I would expect a lot of forecast / target revisions before the results else some of them are going to look very out of touch.

But (there's always a but) coming back to your original question about what I think is most important, and I think it's maybe something they haven't announced yet.

Phil mentions ‘game changer’ upsides in his post there, which none of the analysts are including anything for because they don't do speculation (unlike us).

Serum - the 1,000 litre bioreactor for 10 years - for what? Potentially worth millions.

BMS - it's nearly a year since OXB said in their webcast words to the effect that BMS had expanded their agreement with us on the back of satisfaction, but that OXB were expecting to hear something more from them. You could be forgiven for thinking "11 months = dead in the water" when actually that could simply be the speed at which a huge pharmaceutical company works. Might be another expansion of the agreement, could be anything (or nothing).

Rocket - really we only know that name because Plutonian spotted that their LentiVector looks very much like ours and noted that they don't have one of their own. If their drug is approved on June 30th and if it is our vector then that's millions for us as it moves to commercial supply.

So the 3 Phil mentions there, but I'd also prompt with the reminder that AZ had 11 CDMOs bashing their covid vaccine and they kept the contract open with just one (OXB). Why? Contingency after AZ said publicly that they wouldn't do the same thing again after their covid experiences or were they just very pleased with OXB and thinking "they would be able to help us with ___"?

Another blast from the past here, but what about the article linked here last year linking WuXi with OXB. Maybe that's dead but if not they are a huge company in an even huger market which we have no exposure to.

So the unknown unknowns could be anything, the known unknowns (above) might be something and might be nothing, though personally I think there's so much in the public domain about malaria at the moment that the Serum one is a bit like working out who's farted if there's only 2 of you in a lift. What else could it be? (I am open to other suggestions as to why they want a 1,000 litre bioreactor for 10 years).

But with all the unknowns there, and to finish with something which Dudley Moore's character might have said in Arthur "5 million here, 10 million there, 25 million somewhere else and pretty soon you're talking a lot of money".
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